The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Proteomics for routine identification of microorganisms
Abstract
The invention of MALDI‐TOF‐MS enormously contributed to the understanding of protein chemistry and cell biology. Without this technique proteomics would most likely not be the important discipline it is today. Besides ‘true’ proteomics, MALDI‐TOF‐MS was applied for the analysis of microorganisms for their taxonomic characterization from its beginning. This approach has since been developed as a diagnostic tool readily available for routine, high‐throughput analysis of microbial isolates from clinical specimens by intact‐cell mass spectrometry (ICMS), the direct analysis of whole bacterial cell without a preceding fractionation or separation by chromatography or electrophoresis. ICMS exploits the reproducibility of mass fingerprints for individual bacterial and fungal strains as well as the high similarity of mass fingerprints within a species. Comparison of mass spectral data to genomic sequences emphasized the validity of peak patterns as taxonomic markers. Supported by comprehensive databases, MALDI‐TOF‐MS‐based identification has been widely accepted in clinical laboratories within only a few years.
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Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya.
Woese, C. R., Kandler, O., & Wheelis, M. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4576 · Cited by 6,128
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“Indeed, the success of this technology is already considered as a revolution of bacteriology, offering many advantages compared with the conventional biochemical identification of microorganisms [6, 7].”
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Cited by
MALDI-TOF mass spectrometry: an emerging technology for microbial identification and diagnosis
Singhal, N., Kumar, M., Kanaujia, P. K., & Virdi, J. S. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00791 · Cited by 1,605
Yarrowia lipolytica: Safety assessment of an oleaginous yeast with a great industrial potential
Groenewald, M., Boekhout, T., Neuvéglise, C., Gaillardin, C., van Dijck, P. W. M., & Wyss, M. (2014) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2013.770386 · Cited by 498
Biomedical Mass Spectrometry in Today's and Tomorrow's Clinical Microbiology Laboratories
van Belkum, A., Welker, M., Erhard, M., & Chatellier, S. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.00420-12 · Cited by 100
Self-citationChronic Pulmonary Aspergillosis—Where Are We? and Where Are We Going?
Hayes, G., & Novak-Frazer, L. (2016) · Journal of Fungi · doi:10.3390/jof2020018 · Cited by 77
Metadata
- Authors
- Welker, M.
- Venue
- PROTEOMICS
- Publisher
- Wiley
- Published
- 2011-07-04
- Volume
- 11
- Issue
- 15
- Pages
- 3143-3153
- ISSN
- 1615-9853 (ISSN-L)
- 1615-9861
- OpenAlex
- W2054898376
- Cited by
- 175
- References
- 2
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- closed
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