The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Targeted proteomics for quantification of histone acetylation in Alzheimer's disease
Open accessAbstract
The epigenetic remodeling of chromatin histone proteins by acetylation has been the subject of recent investigations searching for biomarkers indicative of late onset cognitive loss. Histone acetylations affect the regulation of gene transcription, and the loss of learning induced deacetylation at specific histone sites may represent biomarkers for memory loss and A lzheimer's disease (AD). Selected‐reaction‐monitoring (SRM) has recently been advanced to quantitate peptides and proteins in complex biological systems. In this paper, we provide evidence that SRM‐based targeted proteomics can reliably quantify specific histone acetylations in both AD and control brain by identifying the patterns of H 3 K 18/K23 acetylations Results of targeted proteomics assays have been validated by W estern blot (WB) analysis. As compared with LC‐MS/MS‐TMT (tandem‐mass‐tagging) and WB methods, the targeted proteomics method has shown higher throughput, and therefore promised to be more suitable for clinical applications. With this methodology, we find that histone acetylation is significantly lower in AD temporal lobe than found in aged controls. Targeted proteomics warrants increased application for studying epigenetics of neurodegenerative diseases.
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Cites
Recovery of learning and memory is associated with chromatin remodelling
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Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
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A dual pressure linear ion trap orbitrap instrument with very high sequencing speed
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Cited by
History and progress of hypotheses and clinical trials for Alzheimer’s disease
Liu, P.-P., Xie, Y., Meng, X.-Y., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0063-8 · Cited by 723
The epigenetics of aging and neurodegeneration
Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381
Quantitative Proteomic Analysis of Histone Modifications
Huang, H., Lin, S., Garcia, B. A., & Zhao, Y. (2015) · Chemical Reviews · doi:10.1021/cr500491u · Cited by 370
Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease
Nativio, R., Donahue, G., Berson, A., Lan, Y., Amlie-Wolf, A., Tuzer, F., Toledo, J. B., Gosai, S. J., Gregory, B. D., Torres, C., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0101-9 · Cited by 363
Aging and Alzheimer's disease: comparison and associations from molecular to system level
Xia, X., Jiang, Q., McDermott, J., & Han, J. J. (2018) · Aging Cell · doi:10.1111/acel.12802 · Cited by 301
Metadata
- Authors
- Zhang, K., Schrag, M., Crofton, A., Trivedi, R., Vinters, H., & Kirsch, W.
- Venue
- PROTEOMICS
- Publisher
- Wiley
- Published
- 2012-04
- Volume
- 12
- Issue
- 8
- Pages
- 1261-1268
- ISSN
- 1615-9853 (ISSN-L)
- 1615-9861
- OpenAlex
- W2029248372
- Cited by
- 192
- References
- 6
- FWCI
- 6.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, K., Schrag, M., Crofton, A., Trivedi, R., Vinters, H., & Kirsch, W. (2012). Targeted proteomics for quantification of histone acetylation in Alzheimer's disease. PROTEOMICS. https://doi.org/10.1002/pmic.201200010
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