History and progress of hypotheses and clinical trials for Alzheimer’s disease

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Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease

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Exploring the versatility of Drosophila melanogaster as a model organism in biomedical research: a comprehensive review

Atoki, A. V., Aja, P. M., Shinkafi, T. S., Ondari, E. N., Adeniyi, I. A., Fasogbon, I. V., Dangana, R. S., Shehu, U. U., & Akin-Adewumi, A. (2024) · Fly · doi:10.1080/19336934.2024.2420453 · Cited by 69 · see citing works

Structural and Functional Properties of Activator Protein-1 in Cancer and Inflammation

Bhosale, P. B., Kim, H. H., Abusaliya, A., Vetrivel, P., Ha, S. E., Park, M. Y., Lee, H. J., & Kim, G. S. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/9797929 · Cited by 68 · see citing works

Hypoglycemic medicines in the treatment of Alzheimer’s disease: Pathophysiological links between AD and glucose metabolism

Wang, Y., Hu, H., Liu, X., & Guo, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1138499 · Cited by 67 · see citing works

Exercise-Induced Benefits for Alzheimer’s Disease by Stimulating Mitophagy and Improving Mitochondrial Function

Liang, J., Wang, C., Zhang, H., Huang, J., Xie, J., & Chen, N. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.755665 · Cited by 66 · see citing works

Perivascular spaces as a potential biomarker of Alzheimer’s disease

Lynch, M., Pham, W., Sinclair, B., O'Brien, T. J., Law, M., & Vivash, L. E. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1021131 · Cited by 66 · see citing works

Concatenation of molecular docking and molecular simulation of BACE-1, γ-secretase targeted ligands: in pursuit of Alzheimer’s treatment

Jabir, N. R., Rehman, M. T., Alsolami, K., Shakil, S., Zughaibi, T. A., Alserihi, R. F., Khan, M. S., Alajmi, M. F., & Tabrez, S. S. M. (2021) · Annals of Medicine · doi:10.1080/07853890.2021.2009124 · Cited by 65 · see citing works

Electrocatalysis of Copper Sulfide Nanoparticle-Engineered Covalent Organic Frameworks for Ratiometric Electrochemical Detection of Amyloid-β Oligomer

Chen, Y., Wang, S., Ren, J., Zhao, H., Cui, M., Li, N., Li, M. C., & Zhang, C. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c01602 · Cited by 65 · see citing works

Phoenixin: More than Reproductive Peptide

Billert, M., Rak, A., Nowak, K. W., & Skrzypski, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218378 · Cited by 64 · see citing works

Redefining oxidative stress in Alzheimer's disease: Targeting platelet reactive oxygen species for novel therapeutic options

Beura, S. K., Dhapola, R., Panigrahi, A. R., Yadav, P., HariKrishnaReddy, D., & Singh, S. K. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120855 · Cited by 64 · see citing works

Does long-term exposure to air pollution impair physical and mental health in the middle-aged and older adults? — A causal empirical analysis based on a longitudinal nationwide cohort in China

Ju, K., Lu, L., Chen, T., Duan, Z., Chen, D., Liao, W., Zhou, Q., Xu, Z., & Wang, W. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.154312 · Cited by 63 · see citing works

Recent Advances in Drug Development for Alzheimer’s Disease: A Comprehensive Review

Xing, H., Yue, S., Qin, R., Du, X., Wu, Y., Zhangsun, D., & Luo, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083905 · Cited by 63 · see citing works

The amyloid precursor protein: a converging point in Alzheimer’s disease

Delport, A., & Hewer, R. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02863-x · Cited by 48 · see citing works

Alzheimer’s disease: a review on the current trends of the effective diagnosis and therapeutics

Manap, A. S. A., Almadodi, R., Sultana, S., Sebastian, M. G., Kavani, K. S., Lyenouq, V. E., & Shankar, A. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1429211 · Cited by 62 · see citing works

Herpes simplex virus 1 accelerates the progression of Alzheimer’s disease by modulating microglial phagocytosis and activating NLRP3 pathway

Wang, Z., Liu, J., Han, J., Zhang, T., Li, S., Hou, Y., Su, H., Han, F., & Zhang, C. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03166-9 · Cited by 60 · see citing works

Glutamate Neurotoxicity and Destruction of the Blood–Brain Barrier: Key Pathways for the Development of Neuropsychiatric Consequences of TBI and Their Potential Treatment Strategies

Gruenbaum, B. F., Zlotnik, A. A., Fleidervish, I. A., Frenkel, A., & Boyko, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179628 · Cited by 60 · see citing works

Drug delivery strategies with lipid-based nanoparticles for Alzheimer’s disease treatment

Jang, Y.-J., Kang, S.-J., Park, H. S., Lee, D., Kim, J. H., Kim, J.-E., Kim, D., Chung, C., Yoon, J., & Bhang, S. H. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03109-3 · Cited by 62 · see citing works

Pathogenesis of sporadic Alzheimer's disease by deficiency of NMDA receptor subunit GluN3A

Zhong, W., Wu, A., Berglund, K., Gu, X., Jiang, M. Q., Talati, J., Zhao, J., Wei, L., & Yu, S. P. (2022) · Alzheimer's &amp; Dementia · doi:10.1002/alz.12398 · Cited by 59 · see citing works

Amyloid-β and tau aggregation dual-inhibitors: A synthetic and structure-activity relationship focused review

Malafaia, D., Albuquerque, H. M. T., & Silva, A. M. S. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113209 · Cited by 57 · see citing works

A newly synthesized small molecule: the evaluation against Alzheimer's Disease by in silico drug design and computational structure analysis methods

Şahin, S., & Dege, N. (2021) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2021.130337 · Cited by 57 · see citing works

Recent advancement in therapeutic strategies for Alzheimer’s disease: Insights from clinical trials

Khan, T., Waseem, R., Shahid, M., Ansari, J., Ahanger, I. A., Hassan, M. I., & Islam, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102113 · Cited by 57 · see citing works

Rosmarinus officinalis Essential Oil Improves Scopolamine-Induced Neurobehavioral Changes via Restoration of Cholinergic Function and Brain Antioxidant Status in Zebrafish (Danio rerio)

Capatina, L., Boiangiu, R. Ş., Dumitru, G., Napoli, E., Ruberto, G., Hriţcu, L., & Todirașcu-Ciornea, E. (2020) · Antioxidants · doi:10.3390/antiox9010062 · Cited by 57 · see citing works

Fisetin inhibits tau aggregation by interacting with the protein and preventing the formation of β-strands

Xiao, S., Lu, Y.-F., Wu, Q., Yang, J., Chen, J., Zhong, S., Eliezer, D., Tan, Q., & Wu, C. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.02.210 · Cited by 56 · see citing works

In Vivo Neuropharmacological Potential of Gomphandra tetrandra (Wall.) Sleumer and In-Silico Study against β-Amyloid Precursor Protein

Rahman, M. S., Zilani, M. N. H., Islam, M. A., Hasan, M. M., Islam, M. M., Yasmin, F., Biswas, P., Hirashima, A., Rahman, M. A., Hasan, M. N., et al. (2021) · Processes · doi:10.3390/pr9081449 · Cited by 56 · see citing works

Drug discovery from natural products – Old problems and novel solutions for the treatment of neurodegenerative diseases

Maitra, U., Stephen, C. A., & Ciesla, L. M. (2021) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.114553 · Cited by 56 · see citing works

Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease

Improta-Caria, A., Nonaka, C., Cavalcante, B., de Sousa, R. D., Júnior, R. A., & Souza, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144977 · Cited by 51 · see citing works

CoQ10 and Mitochondrial Dysfunction in Alzheimer’s Disease

Fišar, Z., & Hroudová, J. (2024) · Antioxidants · doi:10.3390/antiox13020191 · Cited by 55 · see citing works

New insights in animal models of neurotoxicity-induced neurodegeneration

Sanfeliu, C., Bartra, C., Sunol, C. E., & Rodrı́guez-Farré, E. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1248727 · Cited by 54 · see citing works

Alzheimer’s disease pathogenesis: standing at the crossroad of lipid metabolism and immune response

Wang, Z., Zhang, L., & Qin, C. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00857-6 · Cited by 54 · see citing works

Do the Bugs in Your Gut Eat Your Memories? Relationship between Gut Microbiota and Alzheimer’s Disease

Borsom, E. M., Lee, K., & Cope, E. K. (2020) · Brain Sciences · doi:10.3390/brainsci10110814 · Cited by 54 · see citing works

Oxidative Stress: Glutathione and Its Potential to Protect Methionine-35 of Aβ Peptide from Oxidation

Mandal, P. K., Roy, R. G., & Samkaria, A. (2022) · ACS Omega · doi:10.1021/acsomega.2c02760 · Cited by 53 · see citing works

A Conditionally Releasable “Do not Eat Me” CD47 Signal Facilitates Microglia‐Targeted Drug Delivery for the Treatment of Alzheimer's Disease

Zhang, L., Liu, X., Liu, D., Yu, X., Zhang, L. L., Zhu, J., Lü, S., & Liu, R. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910691 · Cited by 53 · see citing works

Touchscreen cognitive testing: Cross-species translation and co-clinical trials in neurodegenerative and neuropsychiatric disease

Palmer, D. D., Dumont, J. R., Dexter, T. D., Prado, M. A. M., Finger, E. C., Bussey, T. J., & Saksida, L. M. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107443 · Cited by 52 · see citing works

Perspectives for New and More Efficient Multifunctional Ligands for Alzheimer′s Disease Therapy

Zagórska, A., & Jaromin, A. (2020) · Molecules · doi:10.3390/molecules25153337 · Cited by 51 · see citing works

Anti-inflammatory and neuroprotective evaluation of diverse microalgae extracts enriched in carotenoids

Gallego, R., Valdés, A., Suárez-Montenegro, Z. J., Sánchez-Martínez, J. D., Cifuentes, A., Ibáñez, E., & Herrero, M. (2022) · Algal Research · doi:10.1016/j.algal.2022.102830 · Cited by 51 · see citing works

Alzheimer's disease: The role of proteins in formation, mechanisms, and new therapeutic approaches

Gholami, A. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137532 · Cited by 51 · see citing works

The impact of chelating compounds on Cu2+, Fe2+/3+, and Zn2+ ions in Alzheimer's disease treatment

Mazur, T., Malik, M., & Bieńko, D. C. (2024) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2024.112601 · Cited by 51 · see citing works

Metal Nanoparticles in Alzheimer’s Disease

Behera, A., Sa, N., Pradhan, S. P., Swain, S., & Sahu, P. K. (2023) · Journal of Alzheimer's Disease Reports · doi:10.3233/adr-220112 · Cited by 50 · see citing works

Amentoflavone Ameliorates Memory Deficits and Abnormal Autophagy in Aβ25−35-Induced Mice by mTOR Signaling

Cao, B., Zeng, M., Zhang, Q., Zhang, B., Cao, Y.-G., Wu, Y., Feng, W., & Zheng, X. (2021) · Neurochemical Research · doi:10.1007/s11064-020-03223-8 · Cited by 50 · see citing works

The effect of selective serotonin reuptake inhibitors on cognitive function in patients with Alzheimer’s disease and vascular dementia: focusing on fluoxetine with long follow-up periods

Xie, Y., Liu, P.-P., Lian, Y.-J., Liu, H.-B., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0064-7 · Cited by 49 · see citing works

Alzheimer’s Disease: Hypotheses and therapies

Chen, N. (2025) · Theoretical and Natural Science · doi:10.54254/2753-8818/2024.19968

Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses

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Recent Clinical Developments in Alzheimer's Disease

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Clinical Trials in Alzheimer’s Disease: A Hurdle in the Path of Remedy

Oxford, A. E., Stewart, E. S., & Rohn, T. T. (2020) · International Journal of Alzheimer s Disease · doi:10.1155/2020/5380346 · Cited by 109 · see citing works

Alzheimer’s disease hypothesis and related therapies

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