Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

Translating the Histone Code

Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756 · see citing works

Combinatorial patterns of histone acetylations and methylations in the human genome

Wang, Z., Zang, C., Rosenfeld, J. A., Schones, D. E., Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Peng, W., Zhang, M. Q., et al. (2008) · Nature Genetics · doi:10.1038/ng.154 · Cited by 2,331 · see citing works

ATP-citrate lyase links cellular metabolism to histone acetylation

Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298 · see citing works

Gene regulation and DNA damage in the ageing human brain

Lu, T., Pan, Y., Kao, S.-Y., Li, C., Kohane, I., Chan, J., & Yankner, B. A. (2004) · Nature · doi:10.1038/nature02661 · Cited by 1,874 · see citing works

HDAC2 negatively regulates memory formation and synaptic plasticity

Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644 · see citing works

ChIP-seq accurately predicts tissue-specific activity of enhancers

Visel, A., Blow, M. J., Li, Z., Zhang, T., Akiyama, J. A., Holt, A., Plajzer-Frick, I., Shoukry, M., Wright, C., Chen, F., et al. (2009) · Nature · doi:10.1038/nature07730 · Cited by 1,639 · see citing works

Gene expression profile of aging and its retardation by caloric restriction

Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999) · Science · doi:10.1126/science.285.5432.1390 · Cited by 1,473 · see citing works

Recovery of learning and memory is associated with chromatin remodelling

Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M., & Tsai, L.-H. (2007) · Nature · doi:10.1038/nature05772 · Cited by 1,227 · see citing works

Regulation of histone acetylation during memory formation in the hippocampus

Levenson, J. M., O'Riordan, K. J., Brown, K. D., Trinh, M. A., Molfese, D. L., & Sweatt, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402229200 · Cited by 1,131 · see citing works

Chromatin Acetylation, Memory, and LTP Are Impaired in CBP+/− Mice

Alarcón, J. M., Malleret, G., Touzani, K., Vronskaya, S., Ishii, S., Kandel, E. R., & Barco, A. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.021 · Cited by 892 · see citing works

Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

Vecsey, C. G., Hawk, J. D., Lattal, K. M., Stein, J. M., Fabian, S., Attner, M. A., Cabrera, S. M., McDonough, C. B., Brindle, P. K., Abel, T. G., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0296-07.2007 · Cited by 828 · see citing works

CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation

Korzus, E., Rosenfeld, M. G., & Mayford, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.002 · Cited by 823 · see citing works

Hippocampal LTP Is Accompanied by Enhanced F-Actin Content within the Dendritic Spine that Is Essential for Late LTP Maintenance In Vivo

Fukazawa, Y., Saitoh, Y., Ozawa, F., Ohta, Y., Mizuno, K., & Inokuchi, K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00206-x · Cited by 695 · see citing works

Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation

Hargreaves, D. C., Horng, T., & Medzhitov, R. M. (2009) · Cell · doi:10.1016/j.cell.2009.05.047 · Cited by 649 · see citing works

Gene expression changes in the course of normal brain aging are sexually dimorphic

Berchtold, N. C., Cribbs, D. H., Coleman, P. D., Rogers, J., Head, E., Kim, R., Beach, T., Miller, C., Troncoso, J., Trojanowski, J. Q., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806883105 · Cited by 626 · see citing works

Neuroplasticity Failure in Alzheimer's Disease

Mesulam, M.-M. (1999) · Neuron · doi:10.1016/s0896-6273(00)81109-5 · Cited by 449 · see citing works

Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes

Leader, B., Lim, H. J., Carabatsos, M. J., Harrington, A. N., Ecsedy, J., Pellman, D. S., Maas, R. L., & Leder, P. (2002) · Nature Cell Biology · doi:10.1038/ncb880 · Cited by 329 · see citing works

ChIP-seq: welcome to the new frontier

Mardis, E. R. (2007) · Nature Methods · doi:10.1038/nmeth0807-613 · Cited by 244 · see citing works

The Nuclear Kinase Mitogen- and Stress-Activated Protein Kinase 1 Regulates Hippocampal Chromatin Remodeling in Memory Formation

Chwang, W. B., Arthur, J. S. C., Schumacher, A., & Sweatt, J. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2522-07.2007 · Cited by 239 · see citing works

Distinct Roles of HippocampalDe NovoProtein Synthesis and Actin Rearrangement in Extinction of Contextual Fear

Fischer, A., Sananbenesi, F., Schrick, C., Spiess, J., & Radulović, J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5112-03.2004 · Cited by 219 · see citing works

Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender

Xu, X. Z. S., Zhan, M., Duan, W., Prabhu, V. V., Brenneman, R., Wood, W. H., Firman, J., Li, H., Zhang, P., Ibe, C. N., et al. (2007) · Genome biology · doi:10.1186/gb-2007-8-11-r234 · Cited by 100 · see citing works

Murine models of brain aging and age-related neurodegenerative diseases

Jucker, M., & Ingram, D. K. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)02243-7 · Cited by 93 · see citing works

Formin-2, a novel formin homology protein of the cappuccino subfamily, is highly expressed in the developing and adult central nervous system

Leader, B., & Leder, P. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00276-8 · Cited by 72 · see citing works

NMR-Based Metabonomic Investigations into the Metabolic Profile of the Senescence-Accelerated Mouse

Jiang, N., Yan, X., Zhou, W., Zhang, Q., Chen, H., Zhang, Y., & Zhang, X. (2008) · Journal of Proteome Research · doi:10.1021/pr800439b · Cited by 56 · see citing works

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences

Goecks, J., Nekrutenko, A., Taylor, J., & The Galaxy Team (2010) · Genome biology · doi:10.1186/gb-2010-11-8-r86 · Cited by 3,437 · see citing works

Alzheimer Mechanisms and Therapeutic Strategies

Huang, Y., & Mucke, L. (2012) · Cell · doi:10.1016/j.cell.2012.02.040 · Cited by 1,758 · see citing works

DNA methylation aging clocks: challenges and recommendations

Bell, C. G., Lowe, R., Adams, P. D., Baccarelli, A. A., Beck, S., Bell, J. T., Christensen, B. C., Gladyshev, V. N., Heijmans, B. T., Horvath, S., et al. (2019) · Genome Biology · doi:10.1186/s13059-019-1824-y · Cited by 1,025 · see citing works

Ketone bodies as signaling metabolites

Newman, J. C., & Verdin, E. (2014) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.09.002 · Cited by 966 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

β-Hydroxybutyrate: A Signaling Metabolite

Newman, J. C., & Verdin, E. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064916 · Cited by 872 · see citing works

Epigenetics and aging

Pal, S., & Tyler, J. K. (2016) · Science Advances · doi:10.1126/sciadv.1600584 · Cited by 860 · see citing works

The world of protein acetylation

Drazic, A., Myklebust, L. M., Ree, R., & Arnesen, T. (2016) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2016.06.007 · Cited by 799 · see citing works

Stem cell aging: mechanisms, regulators and therapeutic opportunities

Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796 · see citing works

Histone acetylation: molecular mnemonics on the chromatin

Gräff, J., & Tsai, L.-H. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3427 · Cited by 680 · see citing works

Epigenetic regulation of aging: implications for interventions of aging and diseases

Kang, W., Liu, H., Hu, Q., Wang, L., Liu, J., Zheng, Z., Zhang, W., Ren, J., Zhu, F., & Liu, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01211-8 · Cited by 694 · see citing works

The effects of aging in the hippocampus and cognitive decline

Bettio, L. E. B., Rajendran, L., & Gil‐Mohapel, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.030 · Cited by 654 · see citing works

DNA damage and its links to neurodegeneration

Madabhushi, R., Pan, L., & Tsai, L.-H. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.034 · Cited by 654 · see citing works

Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis

Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637 · see citing works

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

Benayoun, B. A., Pollina, E. A., & Brunet, A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4048 · Cited by 610 · see citing works

Lysosome-mediated processing of chromatin in senescence

Ivanov, A., Pawlikowski, J., Manoharan, I., van Tuyn, J., Nelson, D. M., Rai, T. S., Shah, P. P., Hewitt, G., Korolchuk, V. I., Passos, J. F., et al. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201212110 · Cited by 539 · see citing works

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

Mews, P., Donahue, G., Drake, A. M., Luczak, V., Abel, T., & Berger, S. L. (2017) · Nature · doi:10.1038/nature22405 · Cited by 514 · see citing works

Epigenetic mechanisms in cognition

Day, J. J., & Sweatt, J. D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.019 · Cited by 510 · see citing works

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

Li, X., Egervári, G., Wang, Y., Berger, S. L., & Lu, Z. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0029-7 · Cited by 486 · see citing works

Structural plasticity upon learning: regulation and functions

Caroni, P., Donato, F., & Muller, D. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3258 · Cited by 491 · see citing works

Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age

Shoji, H., Takao, K., Hattori, S., & Miyakawa, T. (2016) · Molecular Brain · doi:10.1186/s13041-016-0191-9 · Cited by 452 · see citing works

Epigenetic mechanisms in neurological disease

Jakovcevski, M., & Akbarian, S. (2012) · Nature Medicine · doi:10.1038/nm.2828 · Cited by 450 · see citing works

Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression

Govindarajan, N., Agis-Balboa, R. C., Walter, J., Sananbenesi, F., & Fischer, A. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-110080 · Cited by 405 · see citing works

Environment and Brain Plasticity: Towards an Endogenous Pharmacotherapy

Sale, A., Berardi, N., & Maffei, L. (2014) · Physiological Reviews · doi:10.1152/physrev.00036.2012 · Cited by 402 · see citing works

Epigenetic Regulation in Neurodegenerative Diseases

Berson, A., Nativio, R., Berger, S. L., & Bonini, N. M. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.05.005 · Cited by 386 · see citing works

The epigenetics of aging and neurodegeneration

Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381 · see citing works

Biomarkers of aging

Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 389 · see citing works

Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

Gupta, V., Scheunemann, L., Eisenberg, T., Mertel, S., Bhukel, A., Koemans, T. S., Kramer, J. M., Liu, K. S. Y., Schroeder, S., Stunnenberg, H. G., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3512 · Cited by 374 · see citing works

Epigenetic regulation of gene expression in physiological and pathological brain processes

Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373 · see citing works

Small Changes Huge Impact: The Role of Protein Posttranslational Modifications in Cellular Homeostasis and Disease

Karve, T. M., & Cheema, A. K. (2011) · Journal of Amino Acids · doi:10.4061/2011/207691 · Cited by 364 · see citing works

Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy?

Fleiss, B., & Gressèns, P. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70058-3 · Cited by 367 · see citing works

DNA methylation changes in plasticity genes accompany the formation and maintenance of memory

Halder, R., Hennion, M., Vidal, R. O., Shomroni, O., Rahman, R.-U., Rajput, A., Centeno, T. P., van Bebber, F., Capece, V., Vizcaino, J. C. G., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4194 · Cited by 358 · see citing works

Targeting the correct HDAC(s) to treat cognitive disorders

Fischer, A., Sananbenesi, F., Mungenast, A. E., & Tsai, L. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.09.003 · Cited by 355 · see citing works

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

Govindarajan, N., Rao, P., Burkhardt, S., Sananbenesi, F., Schlüter, O. M., Bradke, F., Lu, J., & Fischer, A. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201201923 · Cited by 346 · see citing works

microRNA-34c is a novel target to treat dementias

Zovoilis, A., Agbemenyah, H. Y., Agis‐Balboa, R. C., Stilling, R. M., Edbauer, D., Rao, P., Farinelli, L., Delalle, I., Schmitt, A., Falkai, P., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.327 · Cited by 298 · see citing works

HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?

Simões-Pires, C., Zwick, V., Nurisso, A., Schenker, E., Carrupt, P.-A., & Cuendet, M. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-7 · Cited by 341 · see citing works

The Role of Histone Acetylation in Memory Formation and Cognitive Impairments

Peixoto, L., & Abel, T. G. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.86 · Cited by 336 · see citing works

The Emerging Field of Neuroepigenetics

Sweatt, J. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.023 · Cited by 324 · see citing works

Physical exercise as an epigenetic modulator of brain plasticity and cognition

Fernandes, J., Arida, R. M., & Gómez‐Pinilla, F. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.06.012 · Cited by 326 · see citing works

Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

Kubben, N., & Misteli, T. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.68 · Cited by 320 · see citing works

Manifestations and mechanisms of stem cell aging

Liu, L. A., & Rando, T. A. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201010131 · Cited by 306 · see citing works

Aging and Alzheimer's disease: comparison and associations from molecular to system level

Xia, X., Jiang, Q., McDermott, J., & Han, J. J. (2018) · Aging Cell · doi:10.1111/acel.12802 · Cited by 301 · see citing works

Microbiota regulation of the mammalian gut-brain axis

Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300 · see citing works

Induction of Epigenetic Alterations by Dietary and Other Environmental Factors

Mathers, J. C., Strathdee, G. R., & Relton, C. L. (2010) · Advances in genetics · doi:10.1016/b978-0-12-380864-6.00001-8 · Cited by 292 · see citing works

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

Klein, P., Dingledine, R. J., Aronica, E., Bernard, C., Blümcke, I., Boison, D., Brodie, M. J., Brooks‐Kayal, A. R., Engel, J., Forcelli, P. A., et al. (2017) · Epilepsia · doi:10.1111/epi.13965 · Cited by 286 · see citing works

Epigenetic changes during aging and their reprogramming potential

Kane, A. E., & Sinclair, D. A. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1570075 · Cited by 283 · see citing works

Epigenetic Mechanisms of Depression and Antidepressant Action

Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134540 · Cited by 277 · see citing works

The amyloid precursor protein: A biochemical enigma in brain development, function and disease

Nalivaeva, N. N., & Turner, A. J. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.05.010 · Cited by 271 · see citing works

A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice

Bilkei‐Gorzó, A., Albayram, Ö., Draffehn, A. M., Michel, K., Piyanova, A., Oppenheimer, H., Dvir‐Ginzberg, M., Rácz, I., Ulas, T., Imbeault, S., et al. (2017) · Nature Medicine · doi:10.1038/nm.4311 · Cited by 271 · see citing works

Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

D’Amato, A., Di Cesare Mannelli, L., Lucarini, E., Man, A. L., Le Gall, G., Branca, J. J. V., Ghelardini, C., Amedei, A., Bertelli, E., Regoli, M., et al. (2020) · Microbiome · doi:10.1186/s40168-020-00914-w · Cited by 269 · see citing works

Chronic Pain: Emerging Evidence for the Involvement of Epigenetics

Denk, F., & McMahon, S. B. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.012 · Cited by 267 · see citing works

Modulation of learning and memory by cytokines: Signaling mechanisms and long term consequences

Donzis, E. J., & Tronson, N. C. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.08.008 · Cited by 254 · see citing works

Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory

Barrett, R. M., Malvaez, M., Kramar, E., Matheos, D. P., Arrizon, A., Cabrera, S. M., Lynch, G., Greene, R. W., & Wood, M. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.61 · Cited by 243 · see citing works

Regulated Noise in the Epigenetic Landscape of Development and Disease

Pujadas, E., & Feinberg, A. P. (2012) · Cell · doi:10.1016/j.cell.2012.02.045 · Cited by 234 · see citing works

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

Ricobaraza, A., Cuadrado‐Tejedor, M., Marco, S., Pérez‐Otaño, I., & García‐Osta, A. (2012) · Hippocampus · doi:10.1002/hipo.20883 · Cited by 239 · see citing works

Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse

Frère, S. G. A., & Slutsky, I. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.028 · Cited by 230 · see citing works

Nutritional influences on epigenetics and age-related disease

Park, L. K., Friso, S., & Choi, S. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665111003302 · Cited by 242 · see citing works

Epigenetic modulation of the renal β-adrenergic–WNK4 pathway in salt-sensitive hypertension

Mu, S., Shimosawa, T., Ogura, S., Wang, H., Uetake, Y., Kawakami-Mori, F., Marumo, T., Yatomi, Y., Geller, D. S., Tanaka, H., et al. (2011) · Nature Medicine · doi:10.1038/nm.2337 · Cited by 236 · see citing works

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

Krishnan, V., Chow, M. Z. Y., Wang, Z., Zhang, L., Liu, B., Liu, X., & Zhou, Z. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102789108 · Cited by 236 · see citing works

Microbes & neurodevelopment – Absence of microbiota during early life increases activity-related transcriptional pathways in the amygdala

Stilling, R. M., Ryan, F. J., Hoban, A. E., Shanahan, F., Clarke, G., Claesson, M. J., Dinan, T. G., & Cryan, J. F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.07.009 · Cited by 233 · see citing works

Plasticity, Robustness, Development and Evolution

(2012) · International Journal of Epidemiology · doi:10.1093/ije/dys033 · Cited by 223 · see citing works

Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies

Ladewig, J., Koch, P., & Brüstle, O. (2013) · Nature reviews. Molecular cell biology · doi:10.1038/nrm3543 · Cited by 233 · see citing works

Epigenetic GABAergic targets in schizophrenia and bipolar disorder

Guidotti, A., Auta, J., Chen, Y., Davis, J. M., Dong, E., Gavin, D. P., Grayson, D. R., Matrisciano, F., Pinna, G., Satta, R., et al. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.10.021 · Cited by 220 · see citing works

microRNAs in Parkinson’s Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches

Leggio, L., Vivarelli, S., L’Episcopo, F., Tirolo, C., Caniglia, S., Testa, N., Marchetti, B., & Iraci, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122698 · Cited by 216 · see citing works

MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration

Feng, Q., Luo, Y., Zhang, X., Yang, X., Hong, X.-Y., Sun, D., Li, X., Hu, Y., Li, X., Zhang, J., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1633862 · Cited by 211 · see citing works

Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases

Pyo, I. S., Yun, S., Yoon, Y. E., Choi, J. W., & Lee, S. (2020) · Molecules · doi:10.3390/molecules25204649 · Cited by 213 · see citing works

The Role of Gut Bacterial Metabolites in Brain Development, Aging and Disease

Tran, S. M.-S., & Mohajeri, M. H. (2021) · Nutrients · doi:10.3390/nu13030732 · Cited by 207 · see citing works

The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy

Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208 · see citing works

Targeting HDACs: A Promising Therapy for Alzheimer's Disease

Xu, K., Dai, X., Huang, H., & Jiang, Z.-F. (2011) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2011/143269 · Cited by 206 · see citing works

Epigenetic mechanisms in neurological and neurodegenerative diseases

Landgrave-Gómez, J., Mercado-Gómez, O. F., & Guevara‐Guzmán, R. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00058 · Cited by 201 · see citing works

Neurocognitive Aging and the Hippocampus across Species

Leal, S. L., & Yassa, M. A. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.10.003 · Cited by 207 · see citing works

Epigenetic activities of flavonoids in the prevention and treatment of cancer

Busch, C., Burkard, M., Leischner, C., Lauer, U. M., Frank, J., & Venturelli, S. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0095-z · Cited by 198 · see citing works

Gestational Hypoxia and Developmental Plasticity

Ducsay, C. A., Goyal, R., Pearce, W. J., Wilson, S. M., Hu, X., & Zhang, L. (2018) · Physiological Reviews · doi:10.1152/physrev.00043.2017 · Cited by 203 · see citing works

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

Hait, N. C., Wise, L. E., Allegood, J. C., O'Brien, M., Avni, D., Reeves, T. M., Knapp, P. E., Lu, J., Luo, C., Miles, M. F., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3728 · Cited by 209 · see citing works

Rapid DNA–protein cross-linking and strand scission by an abasic site in a nucleosome core particle

Sczepanski, J. T., Wong, R. S., McKnight, J. N., Bowman, G. D., & Greenberg, M. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012860108 · Cited by 194 · see citing works

Targeted proteomics for quantification of histone acetylation in A lzheimer's disease

Zhang, K., Schrag, M., Crofton, A. R., Trivedi, R. K., Vinters, H. V., & Kirsch, W. M. (2012) · PROTEOMICS · doi:10.1002/pmic.201200010 · Cited by 191 · see citing works

Histone deacetylases in memory and cognition

Penney, J., & Tsai, L. (2014) · Science Signaling · doi:10.1126/scisignal.aaa0069 · Cited by 192 · see citing works

HDAC inhibitor–dependent transcriptome and memory reinstatement in cognitive decline models

Benito, E., Urbanke, H., Ramachandran, B., Barth, J., Halder, R., Awasthi, A., Jain, G., Capece, V., Burkhardt, S., Navarro-Sala, M., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79942 · Cited by 190 · see citing works

Exercise and Sodium Butyrate Transform a Subthreshold Learning Event into Long-Term Memory via a Brain-Derived Neurotrophic factor-Dependent Mechanism

Intlekofer, K. A., Berchtold, N. C., Malvaez, M., Carlos, A. J., McQuown, S. C., Cunningham, M. J., Wood, M. A., & Cotman, C. W. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.104 · Cited by 190 · see citing works

Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration

Neal, M. P., & Richardson, J. R. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.11.004 · Cited by 185 · see citing works

Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress

Sun, J., Wang, F., Hong, G., Pang, M., Xu, H., Li, H., Tian, F., Fang, R., Yao, Y., & Liu, J. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.03.003 · Cited by 184 · see citing works

HDAC1 Regulates Fear Extinction in Mice

Bahari‐Javan, S., Maddalena, A., Kerimoglu, C., Wittnam, J. L., Held, T., Bähr, M., Burkhardt, S., Delalle, I., Kügler, S., Fischer, A., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0079-12.2012 · Cited by 186 · see citing works

Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease: A Genome-Wide Association Study

Naj, A. C., Jun, G., Reitz, C., Kunkle, B. W., Perry, W., Park, Y. S., Beecham, G. W., Rajbhandary, R. A., Hamilton-Nelson, K. L., Wang, L.-S., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.1491 · Cited by 185 · see citing works

Arc protein: a flexible hub for synaptic plasticity and cognition

Nikolaienko, O., Patil, S. S., Eriksen, M. S., & Bramham, C. R. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.09.006 · Cited by 183 · see citing works

Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan

Bradshaw, P. C. (2021) · Antioxidants · doi:10.3390/antiox10040572 · Cited by 185 · see citing works

The Metabolic Impact on Histone Acetylation and Transcription in Ageing

Peleg, S., Feller, C., Ladurner, A. G., & Imhof, A. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.05.008 · Cited by 178 · see citing works

Actin Out: Regulation of the Synaptic Cytoskeleton

Spence, E. F., & Soderling, S. H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.655118 · Cited by 171 · see citing works

How the epigenome integrates information and reshapes the synapse

Campbell, R. R., & Wood, M. A. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0121-9 · Cited by 175 · see citing works

Oxidative Stress in Cognitive and Epigenetic Aging: A Retrospective Glance

Kandlur, A., Satyamoorthy, K., & Gangadharan, G. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00041 · Cited by 177 · see citing works

Lysine Acetyltransferases CBP and p300 as Therapeutic Targets in Cognitive and Neurodegenerative Disorders

Valor, L. M., Viosca, J., López‐Atalaya, J. P., & Barco, Á. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990382 · Cited by 168 · see citing works

Epigenetic Alterations in Alzheimer’s Disease

Sanchez-Mut, J. V., & Gräff, J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00347 · Cited by 168 · see citing works

Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease

Zheng, Y., Liu, A., Wang, Z.-J., Cao, Q., Wang, W., Lin, L., Ma, K., Zhang, F., Wei, J., Matas, E., et al. (2019) · Brain · doi:10.1093/brain/awy354 · Cited by 168 · see citing works

High-Resolution Genome-wide Mapping of the Primary Structure of Chromatin

Zhang, Z., & Pugh, B. F. (2011) · Cell · doi:10.1016/j.cell.2011.01.003 · Cited by 163 · see citing works

Epigenetic Regulation of Sensory Axon Regeneration after Spinal Cord Injury

Finelli, M. J., Wong, J. K., & Zou, H. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0589-13.2013 · Cited by 167 · see citing works

LRP8-Reelin-regulated neuronal enhancer signature underlying learning and memory formation

Telese, F., Ma, Q., Perez, P. M., Notani, D., Oh, S., Li, W., Comoletti, D., Ohgi, K. A., Taylor, H., & Rosenfeld, M. G. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.033 · Cited by 166 · see citing works

Unfolding personalities: The importance of studying ontogeny

Groothuis, T. G. G., & Trillmich, F. (2011) · Developmental Psychobiology · doi:10.1002/dev.20574 · Cited by 161 · see citing works

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

Kwapis, J. L., Alaghband, Y., Kramár, E. A., López, A. J., Ciernia, A. V., White, A. O., Shu, G., Rhee, D., Michael, C. M., Montellier, E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05868-0 · Cited by 162 · see citing works

GABAergic inhibitory neurons as therapeutic targets for cognitive impairment in schizophrenia

Xu, M., & Wong, A. H. C. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.172 · Cited by 159 · see citing works

Acetate supplementation increases brain histone acetylation and inhibits histone deacetylase activity and expression

Soliman, M. L., & Rosenberger, T. A. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0751-3 · Cited by 158 · see citing works

Science

Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari‐Javan, S., Agis-Balboa, R., Cota, P., Wittnam, J. L., Gogol-Doering, A., Opitz, L., et al. (2010) · MPG.PuRe (Max Planck Society)

Altered Histone 4 K12 Acetylation is Associated with Age Dependent Memory Impairment in Mice

Peleg, S. (2010) · doi:10.53846/goediss-3189

Inhibition of histone lysine demethylase restores learning and memory in aged micePreprint

Bhatt, S. R., MacBean, L. F., Kramár, E. A., Pérez‐Sisqués, L., Smethurst, P., Robb, J. L., Jindal, N., Fetterly, T. L., Graham, A., Wood, M. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.22.695858

Alterations of Histone Acetylation Associated with Cognitive Decline in Mouse Brain During Aging: Genome-Wide Epigenetic AnalysisPreprint

Scheinman, S. B., Carvill, G. L., & Dong, H. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.5045299

Environmental Enrichment Reverses Histone Methylation Changes in the Aged Hippocampus and Restores Age-Related Memory Deficits

Morse, S. J., Butler, A. A., Davis, R. L., Soller, I., & Lubin, F. D. (2015) · Biology · doi:10.3390/biology4020298 · Cited by 75 · see citing works