The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Urinary exosomes: A reservoir for biomarker discovery and potential mediators of intrarenal signalling
Abstract
Over the last decade, there has been increasing research interest in urinary exosomes and their relationship with kidney physiology and disease. Protocols for isolating urinary exosomes have been refined and the exosomal proteome has been extensively catalogued and reported to contain proteins from the kidney's glomerulus and all sections of the nephron. In animal and human biomarker discovery studies, this proteome changes to reflect the underlying pathophysiology of certain kidney diseases. In addition to proteins, exosomes from urine have been demonstrated to contain RNA species, another new reservoir for biomarker discovery. Exosomes have the capacity to shuttle their cargo between kidney cells and change the recipient cell's proteome and function, and may represent a mechanism for cell‐to‐cell signalling along the nephron. Significant challenges remain; methods for urinary exosome collection need optimisation if “real‐life” clinical utility is to be achieved, consensus is needed regarding normalisation of changes in exosomal protein and RNA, larger scale exosome biomarker validation studies remain to be performed, and whether exosomes signal between cells in vivo remains an intriguing, but untested, hypothesis.
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Cites
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930
B lymphocytes secrete antigen-presenting vesicles.
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Tamm-Horsfall protein and urinary exosome isolation
Fernández-Llama, P., Khositseth, S., Gonzales, P. A., Star, R. A., Pisitkun, T., & Knepper, M. A. (2010) · Kidney International · doi:10.1038/ki.2009.550 · Cited by 290
Cited by
Biological properties of extracellular vesicles and their physiological functions
Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926
De Toro, J., Herschlik, L., Waldner, C., & Mongini, C. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00203 · Cited by 615
Exosomes in bodily fluids are a highly stable resource of disease biomarkers
Boukouris, S., & Mathivanan, S. (2015) · PROTEOMICS – Clinical Applications · doi:10.1002/prca.201400114 · Cited by 586
Merchant, M. L., Rood, I. M., Deegens, J. K. J., & Klein, J. B. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.148 · Cited by 494
Corrado, C., Raimondo, S., Chiesi, A., Ciccia, F., De Leo, G., & Alessandro, R. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14035338 · Cited by 396
Metadata
- Authors
- Dear, J. W., Street, J. M., & Bailey, M. A.
- Venue
- PROTEOMICS
- Publisher
- Wiley
- Published
- 2013-02-15
- Volume
- 13
- Issue
- 10-11
- Pages
- 1572-1580
- ISSN
- 1615-9853 (ISSN-L)
- 1615-9861
- OpenAlex
- W2070556690
- Cited by
- 163
- References
- 4
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dear, J. W., Street, J. M., & Bailey, M. A. (2013). Urinary exosomes: A reservoir for biomarker discovery and potential mediators of intrarenal signalling. PROTEOMICS. https://doi.org/10.1002/pmic.201200285
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
