Oncogene‐induced cellular senescence elicits an anti‐ W arburg effect
Open accessAbstract
Cellular senescence, an irreversible cell cycle arrest induced by a diversity of stimuli, has been considered as an innate tumor suppressing mechanism with implications and applications in cancer therapy. Using a targeted proteomics approach, we show that fibroblasts induced into senescence by expression of oncogenic R as exhibit a decrease of global acetylation on all core histones, consistent with formation of senescence‐associated heterochromatic foci. We also detected clear increases in repressive markers (e.g. >50% elevation of H 3 K 27me2/3) along with decreases in histone marks associated with increased transcriptional expression/elongation (e.g. H 3 K 36me2/3). Despite the increases in repressive marks of chromatin, 179 loci (of 2206 total) were found to be upregulated by global quantitative proteomics. The changes in the cytosolic proteome indicated an upregulation of mitochondrial proteins and downregulation of proteins involved in glycolysis. These alterations in primary metabolism are opposite to the well‐known W arburg effect observed in cancer cells. This study significantly improves our understanding of stress‐induced senescence and provides a potential application for triggering it in antiproliferative strategies that target the primary metabolism in cancer cells.
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During OIS, fatty acid metabolism is altered, glucose consumption is enhanced, and utilization of pyruvate in the tricarboxylic acid cycle and nucleotide deficiency are increased.
“Moreover, during OIS, fatty acid metabolism is altered, glucose consumption is enhanced, and the utilization of pyruvate in the tricarboxylic acid cycle and nucleotide deficiency are increased [119,216,217,218,219].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [217]
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Zhu, H., Le, L., Tang, H., Speicher, D. W., & Zhang, R. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6670-7_12 · Cited by 1 · see citing works
Rizos, H., Haferkamp, S., & Scurr, L. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-41319-8_11
Marmisolle, I., Chacón, E., Mansilla, S., Bresque, M., Martínez, J., Martínez‐Zamudio, R. I., Herbig, U., Liu, J., Finkel, T., Escande, C., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4775691
The Translatome of Senescent Cells Revealed by Sequencing Actively Translated mRNAPreprint
Kelsey, M. M. G., Kalekar, R. L., & Sedivy, J. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.27.708233
- Authors
- Li, M., Durbin, K. R., Sweet, S. M. M., Tipton, J. D., Zheng, Y., & Kelleher, N. L.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Kelleher, Neil L.
- Venue
- PROTEOMICS
- Publisher
- Wiley
- Published
- 2013-07-30
- Volume
- 13
- Issue
- 17
- Pages
- 2585-2596
- ISSN
- 1615-9853 (ISSN-L)
- 1615-9861
- PMC
- PMC3867201
- OpenAlex
- W2169073774
- Cited by
- 43
- References
- 54
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 2 · 2013: 1
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- PROTEOMICS (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Packard Foundation
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- oncogene-induced senescence, cellular senescence, Warburg effect, Ras, histone acetylation, senescence-associated heterochromatin foci, H3K27me3, H3K36me3, glycolysis, mitochondrial proteins, primary metabolism, fibroblasts
- MeSH terms
- Acetylation, Cell Line, Chromatin, Chromatography, Liquid, Cytosol, Fibroblasts, Glycolysis, Histones, Humans, Neoplasms, Oncogenes, Transcription, Genetic, Down-Regulation, Up-Regulation, Cellular Senescence, ras Proteins, Proteome, Mitochondrial Proteins, Proteomics, Cell Proliferation, Tandem Mass Spectrometry, Cell Cycle Checkpoints
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