The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
The therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles
Abstract
Extracellular vesicles (EV s), membrane vesicles that are secreted by a variety of mammalian cell types, have been shown to play an important role in intercellular communication. The contents of EV s, including proteins, micro RNA s, and m RNA s, vary according to the cell type that secreted them. Accordingly, researchers have demonstrated that EV s derived from various cell types play different roles in biological phenomena. Considering the ubiquitous presence of mesenchymal stem cells (MSC s) in the body, MSC‐derived EV s may take part in a wide range of events. In particular, MSC s have recently attracted much attention due to the therapeutic effects of their secretory factors. MSC‐derived EV s may therefore provide novel therapeutic approaches. In this review, we first summarize the wide range of functions of EV s released from different cell types, emphasizing that EV s echo the phenotype of their parent cell. Then, we describe the various therapeutic effects of MSC s and pay particular attention to the significance of their paracrine effect. We then survey recent reports on MSC‐derived EV s and consider the therapeutic potential of MSC‐derived EV s. Finally, we discuss remaining issues that must be addressed before realizing the practical application of MSC‐derived EV s, and we provide some suggestions for enhancing their therapeutic efficiency.
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Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine
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Metadata
- Authors
- Katsuda, T., Kosaka, N., Takeshita, F., & Ochiya, T.
- Venue
- PROTEOMICS
- Publisher
- Wiley
- Published
- 2013-02-26
- Volume
- 13
- Issue
- 10-11
- Pages
- 1637-1653
- ISSN
- 1615-9853 (ISSN-L)
- 1615-9861
- OpenAlex
- W2054939463
- Cited by
- 423
- References
- 15
- FWCI
- 12.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Katsuda, T., Kosaka, N., Takeshita, F., & Ochiya, T. (2013). The therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles. PROTEOMICS. https://doi.org/10.1002/pmic.201200373
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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