The DOI matches its Crossref record; 414 of the 414 references it cites were found in a registry or an index.
Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine
Open accessAbstract
Exosomes are a type of extracellular vesicles, produced within multivesicular bodies, that are then released into the extracellular space through a merging of the multivesicular body with the plasma membrane. These vesicles are secreted by almost all cell types to aid in a vast array of cellular functions, including intercellular communication, cell differentiation and proliferation, angiogenesis, stress response, and immune signaling. This ability to contribute to several distinct processes is due to the complexity of exosomes, as they carry a multitude of signaling moieties, including proteins, lipids, cell surface receptors, enzymes, cytokines, transcription factors, and nucleic acids. The favorable biological properties of exosomes including biocompatibility, stability, low toxicity, and proficient exchange of molecular cargos make exosomes prime candidates for tissue engineering and regenerative medicine. Exploring the functions and molecular payloads of exosomes can facilitate tissue regeneration therapies and provide mechanistic insight into paracrine modulation of cellular activities. In this review, we summarize the current knowledge of exosome biogenesis, composition, and isolation methods. We also discuss emerging healing properties of exosomes and exosomal cargos, such as microRNAs, in brain injuries, cardiovascular disease, and COVID-19 amongst others. Overall, this review highlights the burgeoning roles and potential applications of exosomes in regenerative medicine.
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3 retracted
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Cited by
Clinical applications of stem cell-derived exosomes
Tan, F., Li, X., Wang, Z., Li, J., Shahzad, K., & Zheng, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01704-0 · Cited by 708
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Liu, Q., Li, D., Pan, X., & Liang, Y. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02081-0 · Cited by 201
Zhong, L., Wang, J., Wang, P., Liu, X., Liu, P., Cheng, X., Cao, L., Wu, H., Chen, J., & Zhou, L. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03409-1 · Cited by 110
Li, Q., Fu, X., Kou, Y., & Han, N. (2023) · Theranostics · doi:10.7150/thno.84971 · Cited by 63
Metadata
- Authors
- Hade, M. D., Suire, C. N., & Suo, Z.
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2021-08-01
- Volume
- 10
- Issue
- 8
- Pages
- 1959
- ISSN
- 2073-4409 (ISSN-L)
- OpenAlex
- W3188331302
- Cited by
- 607
- References
- 414
- FWCI
- 20.26
- Type
- journal article
- Language
- en
- Open access
- gold
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