Nano‐hydroxyapatite/polyamide66 composite tissue‐engineering scaffolds with anisotropy in morphology and mechanical behaviors
Abstract
Abstract Based on a biomimetic conception, nano‐hydroxyapatite (n‐HA)/polyamide66 (PA66) composite scaffolds were prepared with anisotropic properties both in morphology and mechanical behavior. A novel improved thermally induced phase separation (TIPS) technique was developed to generate orientation‐structured scaffolds for tissue engineering. The physiochemical, morphological, and mechanical properties of the resultant scaffolds were evaluated. According to the results, the improved TIPS method exhibited good processability and reproducibility and enabled the composite scaffolds to have a high content of inorganic fillers. The morphological study proved that the n‐HA/PA66 scaffolds exhibited unidirectional microtubular architecture with high porosity (ca. 80–85%) and an optimal pore size ranging from 200 to 500 μm. Besides, the effect of n‐HA content on the morphology of the scaffolds was studied, and the results indicated that the obtained scaffolds presented an improvement in anisotropic morphology with increase of n‐HA content. The anisotropy was also evaluated in the mechanical properties of the scaffolds, that is, the longitudinal compressive strength and modulus were ∼1.5 times of the transverse ones. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 658–669, 2009
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A nano-HA/polyamide 66 scaffold obtained an orientation-structured scaffold.
“An orientation structured scaffold was obtained [114]”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [114]
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Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration.
Kavitha Sri, A., Arthi, C., Neya, N. R., & Hikku, G. S. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acc99e · Cited by 57 · see citing works
- Authors
- Wang, H., Zuo, Y., Zou, Q., Cheng, L., Huang, D., Wang, L., & Li, Y.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Li, Yubao
- Venue
- Journal of Polymer Science Part A: Polymer Chemistry
- Publisher
- Wiley
- Published
- 2008-12-17
- Volume
- 47
- Issue
- 3
- Pages
- 658-669
- ISSN
- 0887-624X (ISSN-L)
- 1099-0518
- OpenAlex
- W1984461378
- Cited by
- 48
- References
- 51
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 6
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Polymer Science Part A Polymer Chemistry (publishedVersion)
- Funders
- China 973 fund (2007CB936102)
- China-Netherlands Programme Strategic Alliances (2008DFB50120)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- hydroxyapatite nanoparticles, polyamide 66, composite scaffolds, tissue engineering scaffolds, thermally induced phase separation, anisotropic morphology, porosity, pore size, compressive strength, mechanical anisotropy, biomimetic scaffolds, inorganic filler content
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