Cited by 1,271Bone Tissue Engineering Materialsbiodegradable polymer synthesis and propertiesElectrospun Nanofibers in Biomedical Applications

Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering

Wei, Guobao, Ma, Peter X.·2004·Biomaterials

Abstract

To better mimic the mineral component and the microstructure of natural bone, novel nano-hydroxyapatite (NHAP)/polymer composite scaffolds with high porosity and well-controlled pore architectures were prepared using thermally induced phase separation (TIPS) techniques. The morphologies, mechanical properties and protein adsorption capacities of the composite scaffolds were investigated. The high porosity (90% and above) was easily achieved and the pore size was adjusted by varying phase separation parameters. The NHAP particles were dispersed in the pore walls of the scaffolds and bound to the polymer very well. NHAP/polymer scaffolds prepared using pure solvent system had a regular anisotropic but open 3D pore structure similar to plain polymer scaffolds while micro-hydroxyapatite (MHAP)/polymer scaffolds had a random irregular pore structure. The introduction of HAP greatly increased the mechanical properties and improved the protein adsorption capacity. In a dioxane/water mixture solvent system, NHAP-incorporated poly(L-lactic acid) (PLLA) scaffolds developed a fibrous morphology which in turn increased the protein adsorption three fold over non fibrous scaffolds. The results suggest that the newly developed NHAP/polymer composite scaffolds may serve as an excellent 3D substrate for cell attachment and migration in bone tissue engineering.

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Crossref · 10.1016/j.biomaterials.2003.12.005

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Authors
Wei, G., & Ma, P. X.
Affiliations
University of Michigan (US)
Corresponding author
Ma, Peter X.
Venue
Biomaterials
Publisher
Elsevier BV
Published
2004-08
Volume
25
Issue
19
Pages
4749-4757
ISSN
0142-9612 (ISSN-L)
OpenAlex
W2021790237
Cited by
1,271
References
28
Citations by year
2026: 21 · 2025: 24 · 2024: 29 · 2023: 42 · 2022: 56 · 2021: 73 · 2020: 61 · 2019: 83 · 2018: 71 · 2017: 83 · 2016: 96 · 2015: 62 · 2014: 75 · 2013: 76 · 2012: 83
FWCI
24.52
Type
journal article
Language
en
Open access
closed
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords
hydroxyapatite nanoparticles, bone tissue engineering, thermally induced phase separation, porosity control, pore structure, mechanical properties, protein adsorption, poly(L-lactic acid), fibrous morphology
MeSH terms
Adsorption, Animals, Blood Proteins, Cattle, Elasticity, Manufactured Materials, Materials Testing, Membranes, Artificial, Molecular Conformation, Particle Size, Polyesters, Polymers, Surface Properties, Porosity, Durapatite, Bone Substitutes, Cell Culture Techniques, Compressive Strength, Lactic Acid, Tissue Engineering, Nanotubes, Macromolecular Substances

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