The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
The pig as an animal model for human pathologies: A proteomics perspective
Abstract
Traditional biomedical models are easy to manage in experimental facilities and allow fast and affordable basic genetic studies related to human disorders, but in some cases they do not always represent the complexity of their physiology. Translational medicine demands selected models depending on the particularities of the human disease to be investigated, reproducing as closely as possible the evolution, clinical symptoms and molecular pathways, cells or tissues involved in the dysfunction. Thus, pig models offer an alternative because of their anatomical and physiological similarities to humans and the availability of genomic, transcriptomic and, progressively more, proteomic tools for analysis of this species. Furthermore, there is a wide range of natural, selected and transgenic porcine breeds. The present review provides a summary of the applications of the pig as a model for metabolic, cardiovascular, infectious diseases, xenotransplantation and neurological disorders and an overview of the possibilities that the diverse proteomic techniques offer to study these pathologies in depth.
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Genomic responses in mouse models poorly mimic human inflammatory diseases
Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005
Analyses of pig genomes provide insight into porcine demography and evolution
Groenen, M. A. M., Archibald, A. L., Uenishi, H., Tuggle, C. K., Takeuchi, Y., Rothschild, M. F., Rogel-Gaillard, C., Park, C., Milan, D., Megens, H.-J., et al. (2012) · Nature · doi:10.1038/nature11622 · Cited by 1,385
Amyloid-β and tau--a toxic pas de deux in Alzheimer’s disease
Ittner, L. M., & Götz, J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2967 · Cited by 1,269
Application of acute phase protein measurements in veterinary clinical chemistry
Petersen, H. H., Nielsen, J. P., & Heegaard, P. M. H. (2004) · Veterinary Research · doi:10.1051/vetres:2004002 · Cited by 1,060
A critical review of fear tests used on cattle, pigs, sheep, poultry and horses
Forkman, B., Boissy, A., Meunier-Salaün, M.-C., Canali, E., & Jones, R. B. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.03.016 · Cited by 961
Neuroendocrine pharmacology of stress
Carrasco, G. A., & Van de Kar, L. D. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01285-8 · Cited by 914
Worldwide Phylogeography of Wild Boar Reveals Multiple Centers of Pig Domestication
Larson, G., Dobney, K., Albarella, U., Fang, M., Matisoo-Smith, E., Robins, J., Lowden, S., Finlayson, H., Brand, T., Willerslev, E., et al. (2005) · Science · doi:10.1126/science.1106927 · Cited by 910
Acute phase response in animals: a review.
Cray, C., Zaias, J., & Altman, N. H. (2009) · PubMed Central · Cited by 816
The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
Cookson, M. R. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2935 · Cited by 539
Huntingtin aggregation and toxicity in Huntington's disease
Bates, G. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13304-1 · Cited by 525
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Metadata
- Authors
- Bassols, A., Costa, C., Eckersall, P. D., Osada, J., Sabrià, J., & Tibau, J.
- Venue
- PROTEOMICS – Clinical Applications
- Publisher
- Wiley
- Published
- 2014-10
- Volume
- 8
- Issue
- 9-10
- Pages
- 715-731
- ISSN
- 1862-8346 (ISSN-L)
- 1862-8354
- OpenAlex
- W2013606469
- Cited by
- 254
- References
- 134
- FWCI
- 10.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bassols, A., Costa, C., Eckersall, P. D., Osada, J., Sabrià, J., & Tibau, J. (2014). The pig as an animal model for human pathologies: A proteomics perspective. PROTEOMICS – Clinical Applications. https://doi.org/10.1002/prca.201300099
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
