Cited by 104Seaweed-derived Bioactive CompoundsPhytochemistry and Biological ActivitiesAlgal biology and biofuel production

Bioactive Potential of Algae and Algae-Derived Compounds: Focus on Anti-Inflammatory, Antimicrobial, and Antioxidant Effects

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Matin, Maima, Koszarska, Magdalena, Atanasov, Atanas G., Król-Szmajda, Karolina, Jóźwik, Artur, Stelmasiak, Adrian, Hejna, Monika·2024·Molecules

Abstract

Algae, both micro- and macroalgae, are recognized for their rich repository of bioactive compounds with potential therapeutic applications. These marine organisms produce a variety of secondary metabolites that exhibit significant anti-inflammatory, antioxidant, and antimicrobial properties, offering promising avenues for the development of new drugs and nutraceuticals. Algae-derived compounds, including polyphenols, carotenoids, lipids, and polysaccharides, have demonstrated efficacy in modulating key inflammatory pathways, reducing oxidative stress, and inhibiting microbial growth. At the molecular level, these compounds influence macrophage activity, suppress the production of pro-inflammatory cytokines, and regulate apoptotic processes. Studies have shown that algae extracts can inhibit inflammatory signaling pathways such as NF-κB and MAPK, reduce oxidative damage by activating Nrf2, and offer an alternative to traditional antibiotics by combatting bacterial infections. Furthermore, algae’s therapeutic potential extends to addressing diseases such as cardiovascular disorders, neurodegenerative conditions, and cancer, with ongoing research exploring their efficacy in preclinical animal models. The pig model, due to its physiological similarities to humans, is highlighted as particularly suitable for validating the bioactivities of algal compounds in vivo. This review underscores the need for further investigation into the specific mechanisms of action and clinical applications of algae-derived biomolecules.

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  • Algal peptides have been shown to downregulate pro-inflammatory cytokines like TNF-α and IL-6, thereby improving insulin sensitivity.

    “Algal peptides have been shown to downregulate pro-inflammatory cytokines like TNF-α and IL-6, thereby improving insulin sensitivity [102].”

    From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [102]

    Section 2.1 reports that algal extracts and constituents suppress TNF-α and IL-6 in stimulated macrophages, but the examples are polysaccharides and lipids, not peptides. Section 4 discusses algal peptides for other effects; our copy does not report that peptide-driven cytokine suppression improves insulin sensitivity. (LLM, conf=0.88)

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Authors
Matin, M., Koszarska, M., Atanasov, A. G., Król-Szmajda, K., Jóźwik, A., Stelmasiak, A., & Hejna, M.
Affiliations
  • Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences (PL)
  • Warsaw University of Life Sciences (PL)
Corresponding author
Hejna, Monika
Venue
Molecules
Publisher
MDPI AG
Published
2024-10-03
Volume
29
Issue
19
Pages
4695
ISSN
1420-3049 (ISSN-L)
OpenAlex
W4403140326
Cited by
104
References
147
Citations by year
2026: 63 · 2025: 41
FWCI
4.37
Type
journal article
Language
en
Open access
Locations
  • Molecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie (847639)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Keywords
algae, marine microalgae, seaweed, bioactive compounds, secondary metabolites, anti-inflammatory activity, antimicrobial activity, antioxidant activity, polyphenols, carotenoids, polysaccharides, lipids, NF-κB signaling, MAPK signaling, Nrf2, inflammatory cytokines, macrophage activity, oxidative stress, antibiotic alternatives, nutraceuticals, cardiovascular disease, neurodegenerative diseases, cancer, porcine model
MeSH terms
Animals, Anti-Infective Agents, Anti-Inflammatory Agents, Antioxidants, Humans, Seaweed, Oxidative Stress, Microalgae

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