Structural biology of the IL-1 superfamily: key cytokines in the regulation of immune and inflammatory responses
Open accessAbstract
Interleukin-1 superfamily of cytokines (IL-1, IL-18, IL-33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in the IL-1 superfamily have been pursued by structural biologists for nearly 20 years. New insights into these mechanisms were recently provided by the crystal structures of the ternary complexes of IL-1β and its receptors. We will review here the structural biology related to receptor recognition by IL-1 superfamily cytokines and the regulation of its cytokine activities by antagonists.
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Cytokine signaling often shows redundancy, synergy, antagonistic effects, or signaling cascades.
“As cytokine signaling often shows redundancy (53–55), synergy (47), antagonistic effects (56–59) or signaling cascades (60), it seems advisable to take all cytokines that work together or against each other into account and thus measure a whole range instead of a single cytokine.”
From Cytokine Research in Depression: Principles, Challenges, and Open Questions (2019) · cites this paper as [59]
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Cytokine Research in Depression: Principles, Challenges, and Open Questions
Himmerich, H., Patsalos, O., Lichtblau, N., Ibrahim, M. A. A., & Dalton, B. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00030 · Cited by 313 · see citing works
- Authors
- Krumm, B., Xiang, Y., & Deng, J.
- Affiliations
- Oklahoma State University (US)
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Deng, Junpeng
- Venue
- Protein Science
- Publisher
- Wiley
- Published
- 2014-03-04
- Volume
- 23
- Issue
- 5
- Pages
- 526-538
- ISSN
- 0961-8368 (ISSN-L)
- 1469-896X
- PMC
- PMC4005705
- OpenAlex
- W1546841942
- Cited by
- 95
- References
- 77
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 7 · 2023: 7 · 2022: 8 · 2021: 10 · 2020: 14 · 2019: 6 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 4
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Protein Science (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Oklahoma State University
- National Institutes of Health
- Oklahoma Agricultural Experiment Station
- National Institute of Allergy and Infectious Diseases (R01AI079217, AI081928, R01AI081928, AI079217)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- IL-1β, IL-18, IL-33, cytokine receptors, receptor recognition, ternary receptor complex, crystal structure, inflammation, immune regulation
- MeSH terms
- Animals, Humans, Inflammation, Interleukin-1, Models, Molecular, Protein Conformation, Signal Transduction, Crystallography, X-Ray, Interleukin-18, Intercellular Signaling Peptides and Proteins, Interleukin 1 Receptor Antagonist Protein
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