The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
3D domain swapping: A mechanism for oligomer assembly
Open accessAbstract
3D domain swapping is a mechanism for forming oligomeric proteins from their monomers. In 3D domain swapping, one domain of a monomeric protein is replaced by the same domain from an identical protein chain. The result is an intertwined dimer or higher oligomer, with one domain of each subunit replaced by the identical domain from another subunit. The swapped “domain” can be as large as an entire tertiary globular domain, or as small as an α‐helix or a strand of a β‐sheet. Examples of 3D domain swapping are reviewed that suggest domain swapping can serve as a mechanism for functional interconversion between monomers and oligomers, and that domain swapping may serve as a mechanism for evolution of some oligomeric proteins. Domain‐swapped proteins present examples of a single protein chain folding into two distinct structures.
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Cites
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Structural Symmetry and Protein Function
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3D domain swapping: As domains continue to swap
Liu, Y., & Eisenberg, D. (2002) · Protein Science · doi:10.1110/ps.0201402 · Cited by 684
Self-citationFolding funnels, binding funnels, and protein function
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A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone
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The domain swapping of human cystatin C induced by synchrotron radiation
Taube, M., Pietralik, Z., Szymanska, A., Szutkowski, K., Clemens, D., Grubb, A., & Kozak, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-44811-1 · Cited by 20
Sakai, T., Mashima, T., Kobayashi, N., Ogata, H., Duan, L., Fujiki, R., Hengphasatporn, K., Uda, T., Shigeta, Y., Hifumi, E., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43443-4 · Cited by 9
A Designed Zn 2+ Sensor Domain Transmits Binding Information to Transmembrane Histidine Kinases
Hatstat, A. K., Kormos, R., Xu, V., Du, G., Liu, L., Zhang, S.-Q., & DeGrado, W. F. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c02273 · Cited by 1
Goto, Y., Miyafusa, T., & Honda, S. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107464 · Cited by 1
Metadata
- Authors
- Bennett, M. J., Schlunegger, M. P., & Eisenberg, D.
- Venue
- Protein Science
- Publisher
- Wiley
- Published
- 1995-12
- Volume
- 4
- Issue
- 12
- Pages
- 2455-2468
- ISSN
- 0961-8368 (ISSN-L)
- 1469-896X
- OpenAlex
- W1978012062
- Cited by
- 764
- References
- 2
- FWCI
- 9.83
- Type
- journal article
- Language
- en
- Open access
- green
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