The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.
Androgen deprivation therapy for prostate cancer: Current status and future prospects
Abstract
Androgens play a major role in promoting the development and progression of prostate cancer. As a result, androgen ablation or blockade of androgen action through the androgen receptor (AR) has been the cornerstone of treatment of advanced prostate cancer. Different strategies involving this hormonal therapy produce a significant clinical response in most of the patients, but most responders eventually lose dependency, resulting in mortality. Thus, whether hormonal therapy contributes to the improvement of overall survival rates, especially in patients with advanced prostate cancer, remains controversial. However, patients with advanced disease clearly have a benefit from androgen deprivation‐based treatment for palliating their symptoms and for improving the quality of their lives. In order to improve overall survival, novel treatment strategies that prolong the androgen‐dependent state and that are useful for androgen‐independent disease based on specific molecular mechanisms need to be identified. © 2004 Wiley‐Liss, Inc.
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Promotion of Bladder Cancer Development and Progression by Androgen Receptor Signals
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Metadata
- Authors
- Miyamoto, H., Messing, E. M., & Chang, C.
- Venue
- The Prostate
- Publisher
- Wiley
- Published
- 2004-04-26
- Volume
- 61
- Issue
- 4
- Pages
- 332-353
- ISSN
- 0270-4137 (ISSN-L)
- 1097-0045
- OpenAlex
- W2140675573
- Cited by
- 317
- References
- 196
- FWCI
- 16.66
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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