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Cited by 317

The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.

Androgen deprivation therapy for prostate cancer: Current status and future prospects

Miyamoto, Hiroshi, Messing, Edward M., Chang, Chawnshang·2004·The Prostate
DOI 10.1002/pros.20115
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Abstract

Androgens play a major role in promoting the development and progression of prostate cancer. As a result, androgen ablation or blockade of androgen action through the androgen receptor (AR) has been the cornerstone of treatment of advanced prostate cancer. Different strategies involving this hormonal therapy produce a significant clinical response in most of the patients, but most responders eventually lose dependency, resulting in mortality. Thus, whether hormonal therapy contributes to the improvement of overall survival rates, especially in patients with advanced prostate cancer, remains controversial. However, patients with advanced disease clearly have a benefit from androgen deprivation‐based treatment for palliating their symptoms and for improving the quality of their lives. In order to improve overall survival, novel treatment strategies that prolong the androgen‐dependent state and that are useful for androgen‐independent disease based on specific molecular mechanisms need to be identified. © 2004 Wiley‐Liss, Inc.

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Metadata

Authors
Miyamoto, H., Messing, E. M., & Chang, C.
Venue
The Prostate
Publisher
Wiley
Published
2004-04-26
Volume
61
Issue
4
Pages
332-353
ISSN
  • 0270-4137 (ISSN-L)
  • 1097-0045
DOI
10.1002/pros.20115
OpenAlex
W2140675573
Cited by
317
References
196
FWCI
16.66
Type
journal article
Language
en
Open access
closed

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