Hot spots—A review of the protein–protein interface determinant amino‐acid residues

Cited by (769)

Items 101–200 of 769

1. Advancing Covalent Ligand and Drug Discovery beyond Cysteine
   Gibae Kim, R. Justin Grams, Ku‐Lung Hsu · 2025 · Chemical Reviews
2. Metal-Mediated Self-Assembly of Protein Superstructures: Influence of Secondary Interactions on Protein Oligomerization and Aggregation
   Eric N. Salgado, Richard A. Lewis, Jasmin Faraone‐Mennella, F. Akif Tezcan · 2008 · Journal of the American Chemical Society
3. Computational Mapping of Anchoring Spots on Protein Surfaces
   Avraham Ben‐Shimon, Miriam Eisenstein · 2010 · Journal of Molecular Biology
4. Computational Alanine Scanning Mutagenesis: MM-PBSA vs TI
   Martins, Sílvia A., Perez, Marta A. S., Moreira, Irina S., Sousa, Sérgio F., Ramos, M. J., Fernandes, P. A. · 2013 · Journal of Chemical Theory and Computation
5. Fly Fishing for Histones: Catch and Release by Histone Chaperone Intrinsically Disordered Regions and Acidic Stretches
   Christopher Warren, David Shechter · 2017 · Journal of Molecular Biology
6. Computer-Aided Drug Discovery for Undruggable Targets
   Qi Sun, Hanping Wang, Juan Xie, Liying Wang, Junxi Mu, Junren Li, Yuhao Ren, Luhua Lai · 2025 · Chemical Reviews
7. Prediction of hot spots in protein interfaces using a random forest model with hybrid features
   L. Wang, Zhi‐Pan Liu, X.-S. Zhang, L. Chen · 2012 · Protein Engineering Design and Selection
8. Structure-Activity Relationships in Peptide-Antibody Complexes: Implications for Epitope Prediction and Development of Synthetic Peptide Vaccines
   Shu‐wen W. Chen, Marc H.V. Van Regenmortel, Jean‐Luc Pellequer · 2009 · Current Medicinal Chemistry
9. Improved Computation of Protein–Protein Relative Binding Energies with the Nwat-MMGBSA Method
   Irene Maffucci, Alessandro Contini · 2016 · Journal of Chemical Information and Modeling
10. ‘Double water exclusion’: a hypothesis refining the O-ring theory for the hot spots at protein interfaces
    Jinyan Li, Qian Liu · 2009 · Bioinformatics
11. Plucking the high hanging fruit: A systematic approach for targeting protein–protein interactions
    Raj, Monika, Bullock, Brooke N., Arora, Paramjit S. · 2013 · Bioorganic & Medicinal Chemistry
12. AlphaSpace: Fragment-Centric Topographical Mapping To Target Protein–Protein Interaction Interfaces
    David W. Rooklin, Cheng Wang, Joseph Katigbak, Paramjit S. Arora, Yingkai Zhang · 2015 · Journal of Chemical Information and Modeling
13. Constructing structural networks of signaling pathways on the proteome scale
    Guray Kuzu, Özlem Keskin, Attila Gürsoy, Ruth Nussinov · 2012 · Current Opinion in Structural Biology
14. Protein folding and binding can emerge as evolutionary spandrels through structural coupling
    Michael Manhart, Alexandre V. Morozov · 2015 · Proceedings of the National Academy of Sciences
15. COMMD1: A Multifunctional Regulatory Protein
    Mario Riera‐Romo · 2017 · Journal of Cellular Biochemistry
16. Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions
    Zhi-Zheng Wang, Xing-Xing Shi, Guang-Yi Huang, Ge‐Fei Hao, Guang‐Fu Yang · 2023 · Trends in Biochemical Sciences
17. NMR Structure of a Heterodimeric SAM:SAM Complex: Characterization and Manipulation of EphA2 Binding Reveal New Cellular Functions of SHIP2
    Hyeong J. Lee, Prasanta Kumar Hota, Preeti Chugha, Hong Guo, Hui Miao, Liqun Zhang, Soon-Jeung Kim, Lukas Stetzik, Bing-Cheng Wang, Matthias Buck · 2012 · Structure
18. Protein painting reveals solvent-excluded drug targets hidden within native protein–protein interfaces
    Alessandra Luchini, Virginia A. Espina, Lance A. Liotta · 2014 · Nature Communications
19. Algorithmic approaches to protein-protein interaction site prediction
    Tristan Aumentado‐Armstrong, Bogdan Istrate, Robert A. Murgita · 2015 · Algorithms for Molecular Biology
20. Small-molecule inhibitor starting points learned from protein–protein interaction inhibitor structure
    David Ryan Koes, Carlos Jaime Camacho · 2011 · Bioinformatics
21. Protein binding hot spots prediction from sequence only by a new ensemble learning method
    Shanshan Hu, Peng Chen, Bing Wang, Jinyan Li · 2017 · Amino Acids
22. Template-constrained macrocyclic peptides prepared from native, unprotected precursors
    Kenneth V. Lawson, Tristan E. Rose, Patrick G. Harran · 2013 · Proceedings of the National Academy of Sciences
23. Predicting protein–protein interactions in the context of protein evolution
    Anna C. F. Lewis, Ramazan Saeed, Charlotte Mary Deane · 2009 · Molecular BioSystems
24. Direct Keap1-kelch inhibitors as potential drug candidates for oxidative stress-orchestrated diseases: A review on In silico perspective
    Ibrahim Damilare Boyenle, Ukachi Chiamaka Divine, Rofiat Oluwabusola Adeyemi, Kehinde Sulaimon Ayinde, Olamide Tosin Olaoba, Chowdhry Apu, Lei Du, Qian Lü, Xiaoxing Yin, Temitope Isaac Adelusi · 2021 · Pharmacological Research
25. Systematic analysis of ATG13 domain requirements for autophagy induction
    Nora Hieke, Neha Verma, David Schlütermann, Niklas Berleth, Jana Deitersen, Philip Böhler, Fabian Stuhldreier, Wenxian Wu, Sabine Seggewiß, Christoph Peter et al. · 2017 · Autophagy
26. A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent
    Noemi Gioelli, F. Maione, C. Camillo, M. Ghitti, D. Valdembri, Noemi Morello, M. Darche, L. Zentilin, Gabriella Cagnoni, Yaqi Qiu et al. · 2018 · Science Translational Medicine
27. Alanine-scanning mutagenesis of human signal transducer and activator of transcription 1 to estimate loss- or gain-of-function variants
    Reiko Kagawa, Ryoji Fujiki, Miyuki Tsumura, Sonoko Sakata, Shiho Nishimura, Yuval Itan, Xiao‐Fei Kong, Zenichiro Kato, Hidenori Ohnishi, Osamu Hirata et al. · 2016 · Journal of Allergy and Clinical Immunology
28. Thermodynamics of antibody–antigen interaction revealed by mutation analysis of antibody variable regions
    Hiroki Akiba, Kouhei Tsumoto · 2015 · The Journal of Biochemistry
29. Accurate prediction of hot spot residues through physicochemical characteristics of amino acid sequences
    Peng Chen, Jinyan Li, Limsoon Wong, Hiroyuki Kuwahara, Jianhua Z. Huang, Xin Gao · 2013 · Proteins Structure Function and Bioinformatics
30. Modulating Protein-Protein Interactions: From Structural Determinants of Binding to Druggability Prediction to Application
    A. Metz, Emanuele Ciglia, Holger Gohlke · 2012 · Current Pharmaceutical Design
31. Prediction of protein binding sites and hot spots
    Juan Fernández‐Recio · 2011 · Wiley Interdisciplinary Reviews Computational Molecular Science
32. Prediction of Protein–Protein Interaction Sites Using Convolutional Neural Network and Improved Data Sets
    Zengyan Xie, Xiaoya Deng, Kunxian Shu · 2020 · International Journal of Molecular Sciences
33. Computational close up on protein–protein interactions: how to unravel the invisible using molecular dynamics simulations?
    Christin Rakers, Marcel Bermúdez, Bettina G. Keller, Jérémie Mortier, Gerhard Wolber · 2015 · Wiley Interdisciplinary Reviews Computational Molecular Science
34. Conformational ensembles, signal transduction and residue hot spots: application to drug discovery.
    Saliha Ece Acuner, Attila Gürsoy, Özlem Keskin, Ruth Nussinov · 2010 · PubMed
35. Targeting protein–protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?
    Cierpicki, Tomasz, Grembecka, Jolanta · 2015 · Immunological Reviews
36. PIII‐Directed Late‐Stage Ligation and Macrocyclization of Peptides with Olefins by Rhodium Catalysis
    Lei Liu, Xinlong Fan, Boning Wang, Hong Xin Deng, Tianhang Wang, Jie Zheng, Jun Chen, Zhuangzhi Shi, Huan Wang · 2022 · Angewandte Chemie International Edition
37. Disrupting the PCSK9/LDLR protein–protein interaction by an imidazole-based minimalist peptidomimetic
    Mattia Stucchi, Giovanni Grazioso, Carmen Lammi, Silvia Manara, Chiara Zanoni, Anna Arnoldi, Giordano Lesma, Alessandra Silvani · 2016 · Organic & Biomolecular Chemistry
38. New Parameters for Higher Accuracy in the Computation of Binding Free Energy Differences upon Alanine Scanning Mutagenesis on Protein–Protein Interfaces
    Inês C. M. Simões, Inês P. D. Costa, João T. S. Coimbra, Maria João Ramos, Pedro Alexandrino Fernandes · 2016 · Journal of Chemical Information and Modeling
39. Highly Conserved Residues in the Helical Domain of Dengue Virus Type 1 Precursor Membrane Protein Are Involved in Assembly, Precursor Membrane (prM) Protein Cleavage, and Entry
    Szu‐Chia Hsieh, Yi-Chieh Wu, Gang Zou, Vivek R. Nerurkar, Pei‐Yong Shi, Wei‐Kung Wang · 2014 · Journal of Biological Chemistry
40. Mcl-1 inhibitors: a patent review
    Lijia Chen, Steven Fletcher · 2016 · Expert Opinion on Therapeutic Patents
41. Structural Biology of Proline Catabolic Enzymes
    John J. Tanner · 2017 · Antioxidants and Redox Signaling
42. An overview of recent molecular dynamics applications as medicinal chemistry tools for the undruggable site challenge
    Ugo Perricone, Maria Rita Gulotta, Jessica Lombino, Barbara Parrino, Stella Cascioferro, Patrizia Diana, Girolamo Cirrincione, Alessandro Padova · 2018 · MedChemComm
43. Quantitative imaging of electric surface potentials with single-atom sensitivity
    Christian Wagner, Matthew F. B. Green, Michael Maiworm, Philipp Leinen, Taner Esat, Nicola Ferri, Niklas Friedrich, Rolf Findeisen, Alexandre Tkatchenko, Ruslan Temirov et al. · 2019 · Nature Materials
44. Methylation of translation‐associated proteins in S accharomyces cerevisiae: Identification of methylated lysines and their methyltransferases
    Timothy A. Couttas, Mark J. Raftery, Matthew Paul Padula, Ben R. Herbert, Marc Ronald Wilkins · 2012 · PROTEOMICS
45. Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition
    Maryam Raeeszadeh‐Sarmazdeh, Kerrie Greene, Banumathi Sankaran, Gregory Paul Downey, Derek C. Radisky, Evette S. Radisky · 2019 · Journal of Biological Chemistry
46. Structural Insights into the Inhibition of Wnt Signaling by Cancer Antigen 5T4/Wnt-Activated Inhibitory Factor 1
    Yuguang Zhao, Tomas Malinauskas, Karl Harlos, E. Yvonne Jones · 2014 · Structure
47. Functional Evolution of Ribonuclease Inhibitor: Insights from Birds and Reptiles
    Jo E. Lomax, C.M. Bianchetti, Aram Chang, George N. Phillips, Brian G. Fox, Ronald T. Raines · 2014 · Journal of Molecular Biology
48. Energetics of oligomeric protein folding and association
    Colleen Doyle, Jessica Rumfeldt, Helen R. Broom, Aron Broom, Peter B. Stathopulos, Kenrick A. Vassall, Johnathan Almey, Elizabeth M. Meiering · 2012 · Archives of Biochemistry and Biophysics
49. Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody
    Hiroki Akiba, Hiroko Tamura, Masato Kiyoshi, Saeko Yanaka, Kenji Sugase, José M. M. Caaveiro, Kouhei Tsumoto · 2019 · Scientific Reports
50. Rationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition Interface
    Chung-Ming Yu, Hung‐Pin Peng, Ing-Chien Chen, Yu‐Ching Lee, Jun-Bo Chen, Keng‐Chang Tsai, Ching-Tai Chen, Jeng-Yih Chang, Ei-Wen Yang, Po‐Chiang Hsu et al. · 2012 · PLoS ONE
51. Comprehensive Experimental and Computational Analysis of Binding Energy Hot Spots at the NF-κB Essential Modulator/IKKβ Protein–Protein Interface
    Golden, Mary S., Cote, Shaun M., Sayeg, Marianna, Zerbe, Brandon S., Villar, Elizabeth A., Beglov, Dmitri, Sazinsky, Stephen L., Georgiadis, Rosina M., Vajda, Sandor, Kozakov, Dima et al. · 2013 · Journal of the American Chemical Society
52. Predicting protein-ATP binding sites from primary sequence through fusing bi-profile sampling of multi-view features
    Yanan Zhang, Dong‐Jun Yu, Shu-Sen Li, Yongxian Fan, Yan Huang, Hong‐Bin Shen · 2012 · BMC Bioinformatics
53. Alanine-shaving Mutagenesis to Determine Key Interfacial Residues Governing the Assembly of a Nano-cage Maxi-ferritin
    Yu Zhang, Siti Hizratul Raudah, Huihian Teo, Gwenda W.S. Teo, Rongli Fan, Xiaoming Sun, Brendan P. Orner · 2010 · Journal of Biological Chemistry
54. How curcumin affords effective protection against amyloid fibrillation in insulin
    Atefeh Rabiee, Azadeh Ebrahim‐Habibi, Atiyeh Ghasemi, Mohsen Nemat‐Gorgani · 2013 · Food & Function
55. Boosting Prediction Performance of Protein–Protein Interaction Hot Spots by Using Structural Neighborhood Properties
    Lei Deng, Jihong Guan, Xiaoming Wei, Yuan Yi, Qiangfeng Cliff Zhang, Shuigeng Zhou · 2013 · Journal of Computational Biology
56. Understanding Insulin Endocrinology in Decapod Crustacea: Molecular Modelling Characterization of an Insulin-Binding Protein and Insulin-Like Peptides in the Eastern Spiny Lobster, Sagmariasus verreauxi
    Jennifer C. Chandler, Neha S. Gandhi, Ricardo L. Mancera, Gregory G. Smith, Abigail Elizur, Tomer Ventura · 2017 · International Journal of Molecular Sciences
57. Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages
    Jiachen Zang, Hai Chen, Xiaorong Zhang, Chenxi Zhang, Jing Guo, Ming Du, Guanghua Zhao · 2019 · Nature Communications
58. Microscale Thermophoresis as a Tool to Study Protein Interactions and Their Implication in Human Diseases
    Romain Magnez, Christian Bailly, Xavier Thuru · 2022 · International Journal of Molecular Sciences
59. dbAMEPNI: a database of alanine mutagenic effects for protein–nucleic acid interactions
    Ling Liu, Yi Xiong, Hongyun Gao, Dong‐Qing Wei, Julie C. Mitchell, Xiaolei Zhu · 2018 · Database
60. Catalyzed Deposition of Signal Reporter for Highly Sensitive Surface-Enhanced Raman Spectroscopy Immunoassay Based on Tyramine Signal Amplification Strategy
    Cuicui Fu, Sila Jin, Wenbing Shi, Joohee Oh, Haiyan Cao, Young Mee Jung · 2018 · Analytical Chemistry
61. Druggable Orthosteric and Allosteric Hot Spots to Target Protein-protein Interactions
    Ma, Buyong, Nussinov, Ruth · 2014 · Current Pharmaceutical Design
62. Understanding the importance of the aromatic amino-acid residues as hot-spots
    Irina Sousa Moreira, João Miguel da Silva Martins, Rui Miguel Ramos, Pedro Alexandrino Fernandes, Maria João Ramos · 2012 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
63. Shelling the Voronoi interface of protein–protein complexes reveals patterns of residue conservation, dynamics, and composition
    Benjamin Bouvier, Raik Grünberg, Michaël Nilges, Frédéric Cazals · 2009 · Proteins Structure Function and Bioinformatics
64. Mapping Allostery through Computational Glycine Scanning and Correlation Analysis of Residue–Residue Contacts
    Quentin R. Johnson, Richard J. Lindsay, Ricky B. Nellas, Elias J. Fernandez, Tongye Shen · 2015 · Biochemistry
65. Side-Chain Conformational Preferences Govern Protein–Protein Interactions
    Andrew M. Watkins, Richard Bonneau, Paramjit S. Arora · 2016 · Journal of the American Chemical Society
66. Scanning Protein Surfaces with DNA‐Encoded Libraries
    Verena B. K. Kunig, Marco Potowski, Mateja Klika Škopić, Andreas Brunschweiger · 2020 · ChemMedChem
67. Targeting protein-protein interaction interfaces in COVID-19 drug discovery
    Chung‐ke Chang, Shanmeng Lin, Roshan Satange, Shih‐Chao Lin, Sin-Cih Sun, Hung‐Yi Wu, Kylene Kehn‐Hall, Ming‐Hon Hou · 2021 · Computational and Structural Biotechnology Journal
68. Structural insights for HIV-1 therapeutic strategies targeting Vif
    Jason D. Salter, Guillermo A. Morales, Harold C. Smith · 2014 · Trends in Biochemical Sciences
69. Evolution of protein structures and interactions from the perspective of residue contact networks
    Xiuwei Zhang, Tina Perica, Sarah Amalia Teichmann · 2013 · Current Opinion in Structural Biology
70. Molecular recognition in the human immunodeficiency virus capsid and antiviral design
    Rebeca Bocanegra, Alicia Rodríguez‐Huete, Miguel Angel Fuertes, Marta del Álamo, Mauricio G. Mateu · 2012 · Virus Research
71. Medicinal Chemistry for 2020
    Seetharama D. Satyanarayanajois, Ronald A. Hill · 2011 · Future Medicinal Chemistry
72. Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5
    Sini M. Kinnunen, Mika J. Välimäki, Marja Tölli, Gerd Wohlfahrt, Rami Darwich, Hiba Komati, Mona J. Nemer, Heikki J Ruskoaho · 2015 · PLoS ONE
73. The FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment
    Takuya Sato, Noriko Gotoh · 2009 · Expert Opinion on Therapeutic Targets
74. Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface
    Takefumi Yamashita, Eiichi Mizohata, Satoru Nagatoishi, Takahiro Watanabe, Makoto Nakakido, Hiroko Iwanari, Yasuhiro Mochizuki, Taisuke Nakayama, Yuji Kado, Yuki Yokota et al. · 2018 · Structure
75. Emerging Pharmacotherapeutic Strategies to Overcome Undruggable Proteins in Cancer
    Yuqing Lu, Yuewen Yang, Guanghao Zhu, Hairong Zeng, Yi‐Ming Fan, Fujia Guo, Dongshu Xu, Boya Wang, Dapeng Chen, Guang‐Bo Ge · 2023 · International Journal of Biological Sciences
76. Broad Distribution of Energetically Important Contacts across an Extended Protein Interface
    Lisa M. Johnson, W. Seth Horne, Samuel H. Gellman · 2011 · Journal of the American Chemical Society
77. Interface residues of transient protein-protein complexes have extensive intra-protein interactions apart from inter-protein interactions
    Srinivasan Jayashree, Pavalam Murugavel, Ramanathan Sowdhamini, Narayanaswamy Srinivasan · 2019 · Biology Direct
78. From Concepts to Inhibitors: A Blueprint for Targeting Protein–Protein Interactions
    Seong Ho Hong, Thu Trang Nguyễn, Joseph F. Ongkingco, Alex Nazzaro, Paramjit S. Arora · 2025 · Chemical Reviews
79. Tetramerization and interdomain flexibility of the replication initiation controller YabA enables simultaneous binding to multiple partners
    Liza Figueiredo Felicori, Katie H. Jameson, Pierre Roblin, Mark J. Fogg, Tránsito García‐García, Magali Ventroux, Mickaël V. Cherrier, Alexandre Bazin, Philippe H. Noirot, Anthony J. Wilkinson et al. · 2015 · Nucleic Acids Research
80. Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs
    Spencer A. Hughes, Fengbin Wang, Shengyuan Wang, Mark A. B. Kreutzberger, Tomasz Osinski, Albina Orlova, Joseph S. Wall, Xiaobing Zuo, Edward H. Egelman, Vincent P. Conticello · 2019 · Proceedings of the National Academy of Sciences
81. Interaction Energetics and Druggability of the Protein–Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2)
    Mengqi Zhong, A.J. Lynch, Samantha N. Muellers, Stefan Jehle, Lingqi Luo, David R. Hall, Reina Iwase, James P. Carolan, Megan E. Egbert, Amanda Wakefield et al. · 2019 · Biochemistry
82. Tau Protein and Tauopathies: Exploring Tau Protein–Protein and Microtubule Interactions, Cross‐Interactions and Therapeutic Strategies
    Davide Di Lorenzo · 2024 · ChemMedChem
83. Discovery of structure-based small molecular inhibitor of αB-crystallin against basal-like/triple-negative breast cancer development in vitro and in vivo
    Zhijuan Chen, Qing Ruan, Song Han, Lei Xi, Wen G. Jiang, Huabei Jiang, David A. Ostrov, Jun Cai · 2014 · Breast Cancer Research and Treatment
84. Hot Spots in a Network of Functional Sites
    Pemra Özbek, Seren Soner, Türkan Haliloǧlu · 2013 · PLoS ONE
85. Computational Alanine Scanning Mutagenesis—An Improved Methodological Approach for Protein–DNA Complexes
    Rui Miguel Ramos, Irina Sousa Moreira · 2013 · Journal of Chemical Theory and Computation
86. Increased Conformational Flexibility of a Macrocycle–Receptor Complex Contributes to Reduced Dissociation Rates
    Adrian Glas, Eike‐Christian Wamhoff, Dennis M. Krüger, Christoph Rademacher, Tom N. Grossmann · 2017 · Chemistry - A European Journal
87. A feature-based approach to predict hot spots in protein–DNA binding interfaces
    Sijia Zhang, Le Zhao, Chun-Hou Zheng, Junfeng Xia · 2019 · Briefings in Bioinformatics
88. Allosteric HIV‐1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter‐subunit interactions: Structural and thermodynamic modeling studies
    Deng, Nanjie, Hoyte, Ashley, Mansour, Yara E., Mohamed, Mosaad S., Fuchs, James R., Engelman, Alan N., Kvaratskhelia, Mamuka, Levy, Ronald · 2016 · Protein Science
89. Molecular Characterization of the Interaction between Sialylated Neisseria gonorrhoeae and Factor H
    Jutamas Shaughnessy, Sanjay Ram, Arnab Bhattacharjee, Joana Pedrosa, Connie Tran, Gabor L Horvath, Brian G. Monks, Alberto Visintin, T. Sakari Jokiranta, Peter A. Rice · 2011 · Journal of Biological Chemistry
90. Chemical Fragments that Hydrogen Bond to Asp, Glu, Arg, and His Side Chains in Protein Binding Sites
    A. W. Edith Chan, Roman Aleksander Laskowski, David L. Selwood · 2010 · Journal of Medicinal Chemistry
91. Disruption of protein–protein interactions: hot spot detection, structure-based virtual screening and in vitro testing for the anti-cancer drug target – survivin
    Sailu Sarvagalla, Chun Hei Antonio Cheung, Ju-Ya Tsai, Hsing‐Pang Hsieh, Mohane Selvaraj Coumar · 2016 · RSC Advances
92. Involvement of the N-terminal B-box Domain of Arabidopsis BBX32 Protein in Interaction with Soybean BBX62 Protein
    Qungang Qi, Ann Gibson, Xiaoran Fu, Meiying Zheng, Rosemarie Kuehn, Yongcheng Wang, Yanfei Wang, Santiago Navarro, James A. Morrell, Dongming Jiang et al. · 2012 · Journal of Biological Chemistry
93. The role of entropy and polarity in intermolecular contacts in protein crystals
    Marcin P. Cieslik, Zygmunt S. Derewenda · 2009 · Acta Crystallographica Section D Biological Crystallography
94. Computer-aided design of aptamers for cytochrome p450
    Dmitrii S. Shcherbinin, Oksana V. Gnedenko, Svetlana A. Khmeleva, Sergey A. Usanov, Andrei A. Gilep, Aliaksei V. Yantsevich, Tatsiana V. Shkel, Ivan V. Yushkevich, Sergey P. Radko, Alexis S. Ivanov et al. · 2015 · Journal of Structural Biology
95. Specific ion effects on macromolecular interactions in E scherichia coli extracts
    Ciara Kyne, Brian C. Ruhle, Virginie Gautier, Peter B. Crowley · 2014 · Protein Science
96. Computational design of second‐site suppressor mutations at protein–protein interfaces
    Deanne W. Sammond, Ziad M. Eletr, Carrie Purbeck, Brian A. Kuhlman · 2009 · Proteins Structure Function and Bioinformatics
97. Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21
    Isabel Leung, Ayelet Dekel, Julia M. Shifman, Sachdev S. Sidhu · 2016 · Proceedings of the National Academy of Sciences
98. Different stapling-based peptide drug design: Mimicking α-helix as inhibitors of protein–protein interaction
    Xiang Li, Yan Zou, Honggang Hu · 2018 · Chinese Chemical Letters
99. Arbitrary protein−protein docking targets biologically relevant interfaces
    Juliette Martin, Richard Lavery · 2012 · BMC Biophysics
100. The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity
     May Levin, Michal Stark, Yehuda G. Assaraf · 2018 · Oncotarget