The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
RNA interference in Lepidoptera: An overview of successful and unsuccessful studies and implications for experimental design
Open accessAbstract
Gene silencing through RNA interference (RNAi) has revolutionized the study of gene function, particularly in non-model insects. However, in Lepidoptera (moths and butterflies) RNAi has many times proven to be difficult to achieve. Most of the negative results have been anecdotal and the positive experiments have not been collected in such a way that they are possible to analyze. In this review, we have collected detailed data from more than 150 experiments including all to date published and many unpublished experiments. Despite a large variation in the data, trends that are found are that RNAi is particularly successful in the family Saturniidae and in genes involved in immunity. On the contrary, gene expression in epidermal tissues seems to be most difficult to silence. In addition, gene silencing by feeding dsRNA requires high concentrations for success. Possible causes for the variability of success in RNAi experiments in Lepidoptera are discussed. The review also points to a need to further investigate the mechanism of RNAi in lepidopteran insects and its possible connection to the innate immune response. Our general understanding of RNAi in Lepidoptera will be further aided in the future as our public database at http://insectacentral.org/RNAi will continue to gather information on RNAi experiments.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Mao, Y.-B., Cai, W.-J., Wang, J.-W., Hong, G.-J., Tao, X.-Y., Wang, L.-J., Huang, Y.-P., & Chen, X.-Y. (2007) · Nature Biotechnology · doi:10.1038/nbt1352 · Cited by 1,358 · cited 3×
“…32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 Terenius et al. RNAi in Lepidoptera 18 2007; Mao et al., 2007; Soberón et al., 2007; Terenius et al., 2007; Zhuang et al., 2007; 402 Mrinal and Nagaraju, 2008; Whyard et al., 2009; Yang et al.,…”
BackgroundResultInfluentialGenome-wide analysis of Notch signalling in Drosophila by transgenic RNAi
Mummery-Widmer, J. L., Yamazaki, M., Stoeger, T., Novatchkova, M., Bhalerao, S., Chen, D., Dietzl, G., Dickson, B. J., & Knoblich, J. A. (2009) · Nature · doi:10.1038/nature07936 · Cited by 305
Ecdysone: Structures and Functions
(2009) · doi:10.1007/978-1-4020-9112-4 · Cited by 160
Self-citation
Cited by
Bolognesi, R., Ramaseshadri, P., Anderson, J., Bachman, P., Clinton, W., Flannagan, R., Ilagan, O., Lawrence, C., Levine, S., Moar, W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047534 · Cited by 473
Molecular mechanisms influencing efficiency of RNA interference in insects
Cooper, A. M., Silver, K., Zhang, J., Park, Y., & Zhu, K. Y. (2019) · Pest Management Science · doi:10.1002/ps.5126 · Cited by 435
Next-generation insect-resistant plants: RNAi-mediated crop protection
Zhang, J., Khan, S. A., Heckel, D. G., & Bock, R. (2017) · Trends in Biotechnology · doi:10.1016/j.tibtech.2017.04.009 · Cited by 348
Self-citationMolecular basis of juvenile hormone signaling
Jindra, M., Bellés, X., & Shinoda, T. (2015) · Current Opinion in Insect Science · doi:10.1016/j.cois.2015.08.004 · Cited by 281
Yan, S., Qian, J., Cai, C., Ma, Z., Li, J., Yin, M., Ren, B., & Shen, J. (2020) · Journal of Pest Science · doi:10.1007/s10340-019-01157-x · Cited by 281
Self-citation
Metadata
- Authors
- Terenius, O., Papanicolaou, A., Garbutt, J. S., Eleftherianos, I., Huvenne, H., Kanginakudru, S., Albrechtsen, M., An, C., Aymeric, J.-L., Barthel, A., Bebas, P., Bitra, K., Bravo, A., Chevalier, F., Collinge, D. P., Crava, C. M., de Maagd, R. A., Duvic, B., Erlandson, M., Faye, I., Felföldi, G., Fujiwara, H., Futahashi, R., Gandhe, A. S., Gatehouse, H. S., Gatehouse, L. N., Giebultowicz, J. M., Gómez, I., Grimmelikhuijzen, C. J. P., Groot, A. T., Hauser, F., Heckel, D. G., Hegedus, D. D., Hrycaj, S., Huang, L., Hull, J. J., Iatrou, K., Iga, M., Kanost, M. R., Kotwica, J., Li, C., Li, J., Liu, J., Lundmark, M., Matsumoto, S., Meyering-Vos, M., Millichap, P. J., Monteiro, A., Mrinal, N., Niimi, T., Nowara, D., Ohnishi, A., Oostra, V., Ozaki, K., Papakonstantinou, M., Popadic, A., Rajam, M. V., Saenko, S., Simpson, R. M., Soberón, M., Strand, M. R., Tomita, S., Toprak, U., Wang, P., Wee, C. W., Whyard, S., Zhang, W., Nagaraju, J., ffrench-Constant, R. H., Herrero, S., Gordon, K., Swevers, L., & Smagghe, G.
- Venue
- Journal of Insect Physiology
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 57
- Issue
- 2
- Pages
- 231-245
- ISSN
- 0022-1910 (ISSN-L)
- OpenAlex
- W2143427287
- Cited by
- 864
- References
- 4
- FWCI
- 13.82
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: RNA interference in Lepidoptera: An overview of successful and unsuccessful studies and implications for experimental design. https://app.cochat.ai/papers/10.1016/j.jinsphys.2010.11.006
- The paper
- Terenius, O., Papanicolaou, A., Garbutt, J. S., Eleftherianos, I., Huvenne, H., Kanginakudru, S., Albrechtsen, M., An, C., Aymeric, J.-L., Barthel, A., Bebas, P., Bitra, K., Bravo, A., Chevalier, F., Collinge, D. P., Crava, C. M., de Maagd, R. A., Duvic, B., Erlandson, M., . . . Smagghe, G. (2011). RNA interference in Lepidoptera: An overview of successful and unsuccessful studies and implications for experimental design. Journal of Insect Physiology. https://doi.org/10.1016/j.jinsphys.2010.11.006
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
