The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Towards the elements of successful insect RNAi
Open accessAbstract
RNA interference (RNAi), the sequence-specific suppression of gene expression, offers great opportunities for insect science, especially to analyze gene function, manage pest populations, and reduce disease pathogens. The accumulating body of literature on insect RNAi has revealed that the efficiency of RNAi varies between different species, the mode of RNAi delivery, and the genes being targeted. There is also variation in the duration of transcript suppression. At present, we have a limited capacity to predict the ideal experimental strategy for RNAi of a particular gene/insect because of our incomplete understanding of whether and how the RNAi signal is amplified and spread among insect cells. Consequently, development of the optimal RNAi protocols is a highly empirical process. This limitation can be relieved by systematic analysis of the molecular physiological basis of RNAi mechanisms in insects. An enhanced conceptual understanding of RNAi function in insects will facilitate the application of RNAi for dissection of gene function, and to fast-track the application of RNAi to both control pests and develop effective methods to protect beneficial insects and non-insect arthropods, particularly the honey bee (Apis mellifera) and cultured Pacific white shrimp (Litopenaeus vannamei) from viral and parasitic diseases.
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Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
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Expression profiling reveals off-target gene regulation by RNAi
Jackson, A. L., Bartz, S. R., Schelter, J., Kobayashi, S. V., Burchard, J., Mao, M., Li, B., Cavet, G., & Linsley, P. S. (2003) · Nature Biotechnology · doi:10.1038/nbt831 · Cited by 2,370
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“When CBW was exposed to either Arabidopsis thaliana or Nicotiana tobacum expressing CYP6AE14 dsRNA, levels of this transcript in the insect midgut decreased, larval growth was retarded, and both effects were more dramatic in the presence of gossypol (Mao et al., 2007).”
Influential3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets
Birmingham, A., Anderson, E. M., Reynolds, A., Ilsley-Tyree, D., Leake, D., Fedorov, Y., Baskerville, S., Maksimova, E., Robinson, K., Karpilow, J., et al. (2006) · Nature Methods · doi:10.1038/nmeth854 · Cited by 920
Bolognesi, R., Ramaseshadri, P., Anderson, J., Bachman, P., Clinton, W., Flannagan, R., Ilagan, O., Lawrence, C., Levine, S., Moar, W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047534 · Cited by 473
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Cited by
Insect immunology and hematopoiesis
Hillyer, J. F. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2015.12.006 · Cited by 561
Molecular mechanisms influencing efficiency of RNA interference in insects
Cooper, A. M., Silver, K., Zhang, J., Park, Y., & Zhu, K. Y. (2019) · Pest Management Science · doi:10.1002/ps.5126 · Cited by 435
Self-citationKhajuria, C., Ivashuta, S., Wiggins, E., Flagel, L., Moar, W., Pleau, M., Miller, K., Zhang, Y., Ramaseshadri, P., Jiang, C., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197059 · Cited by 251
Bachman, P. M., Huizinga, K. M., Jensen, P. D., Mueller, G., Tan, J., Uffman, J. P., & Levine, S. L. (2016) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2016.08.001 · Cited by 123
Ibrahim, A. B., Monteiro, T. R., Cabral, G. B., & Aragão, F. J. L. (2017) · Transgenic Research · doi:10.1007/s11248-017-0035-0 · Cited by 66
Metadata
- Authors
- Scott, J. G., Michel, K., Bartholomay, L. C., Siegfried, B. D., Hunter, W. B., Smagghe, G., Zhu, K. Y., & Douglas, A. E.
- Venue
- Journal of Insect Physiology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 59
- Issue
- 12
- Pages
- 1212-1221
- ISSN
- 0022-1910 (ISSN-L)
- OpenAlex
- W2030262874
- Cited by
- 486
- References
- 6
- FWCI
- 14.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Scott, J. G., Michel, K., Bartholomay, L. C., Siegfried, B. D., Hunter, W. B., Smagghe, G., Zhu, K. Y., & Douglas, A. E. (2013). Towards the elements of successful insect RNAi. Journal of Insect Physiology. https://doi.org/10.1016/j.jinsphys.2013.08.014
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