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Cited by 288

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Ferulic acid alleviates lipid peroxidation in diabetic rats

Balasubashini, M. Sri, Rukkumani, R., Viswanathan, P., Menon, Venugopal P.·2004·Phytotherapy Research
DOI 10.1002/ptr.1440
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Abstract

Diabetes mellitus is a metabolic disorder associated with increased formation of free radicals. The objective of our study was to determine whether ferulic acid (FA), a phenolic acid, has any role to play in diabetes induced free radical formation. Diabetes was induced with streptozotocin. The levels of blood glucose, thiobarbituric acid reactive substances (TBARS), hydroperoxides and free fatty acids (FFA) increased in the liver of diabetic animals. The activities of glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) decreased in the liver. Histopathology of pancreas also shows shrunken islets. Supplementation of FA to the diabetic rats resulted in a decrease in the levels of glucose, TBARS, hydroperoxides, FFA and an increase in reduced glutathione (GSH). FA also resulted in increased activities of SOD, CAT, GPx and expansion of pancreatic islets. The effect was much pronounced with lower dose treatment. Thus our study shows that administration of ferulic acid helps in enhancing the antioxidant capacity of these diabetic animals by neutralizing the free radicals formed thereby reducing the intensity of diabetes. Copyright © 2004 John Wiley & Sons, Ltd.

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Metadata

Authors
Balasubashini, M. S., Rukkumani, R., Viswanathan, P., & Menon, V. P.
Venue
Phytotherapy Research
Publisher
Wiley
Published
2004-04
Volume
18
Issue
4
Pages
310-314
ISSN
  • 0951-418X (ISSN-L)
  • 1099-1573
DOI
10.1002/ptr.1440
OpenAlex
W2037284265
Cited by
288
References
20
FWCI
3.82
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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