Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities
Abstract
Herb extracts commercially used in Asia were screened for their estrogenic activity with a recombinant yeast system with both a human estrogen receptor (ER) expression plasmid and a reporter plasmid. Pueraria lobata (flower) had the highest estrogenic relative potency (RP, 17‐estradiol = 1.00) (7.8e‐3) (RP for + control), followed by Amomum xanthioides (1.3e‐3), Glycyrrhiza uralensis, Zingiber officinale, Rheum palmatum, Curcuma aromatica, Eriobotrya japonica, Sophora flavescens, Anemarrhena asphodeloides, Polygonum multiflorum and Pueraria lobata (root) (9.5e‐4–1.0e‐4), and Prunus persica, Lycoppus lucidus and Adenophora stricta (9.0e‐5–8.0e‐5). In the antiproliferative assay, five human cancer cell lines representing different tissues (breast, lung and ovary) were used. Eriobotrya japonica showed strong cytotoxicity in ER‐negative breast cancer (MDA‐MB‐231), cervix epitheloid (HeLa) and lung (A549) carcinoma cell lines. Copyright © 2006 John Wiley & Sons, Ltd.
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Methanol root extraction of Sophora flavescens stimulated a 400% upsurge of estrogenic activity in a yeast ER action evaluation.
“The use of methanol for the root extraction of S. flavescens stimulated a 400% upsurge of EA in a yeast ER action evaluation [85]”
From Phytotherapy: A promising approach for the treatment of Alzheimer's disease (2022) · cites this paper as [85]
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Phytotherapy: A promising approach for the treatment of Alzheimer's disease
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- Authors
- Kang, S. C., Lee, C. M., Choi, H., Lee, J. H., Oh, J. S., Kwak, J. H., & Zee, O. P.
- Affiliations
- Sungkyunkwan University (KR)
- Corresponding author
- Zee, Ok Pyo
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2006-08-14
- Volume
- 20
- Issue
- 11
- Pages
- 1017-1019
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2062721141
- Cited by
- 67
- References
- 14
- Citations by year
- 2024: 3 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 2 · 2014: 3 · 2013: 7 · 2012: 4
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- estrogenic activity, antiproliferative activity, human estrogen receptor, Pueraria lobata, Eriobotrya japonica, Glycyrrhiza uralensis, ginger, Rheum palmatum, Curcuma aromatica, Sophora flavescens, Anemarrhena asphodeloides, Polygonum multiflorum, peach, Lycopus lucidus, cytotoxicity, breast cancer, cervical cancer, lung cancer, cancer cell lines
- MeSH terms
- Methanol, Asia, beta-Galactosidase, Estrogens, HeLa Cells, Humans, Plant Extracts, Plants, Medicinal, Receptors, Estrogen, Saccharomyces cerevisiae, Genes, Reporter, Toxicity Tests, Organisms, Genetically Modified, Cell Line, Tumor, Cell Proliferation
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