Estrogenic plants: to prevent neurodegeneration and memory loss and other symptoms in women after menopause
Open accessAbstract
In mammals, sexual hormones such as estrogens play an essential role in maintaining brain homeostasis and function. Estrogen deficit in the brain induces many undesirable symptoms such as learning and memory impairment, sleep and mood disorders, hot flushes, and fatigue. These symptoms are frequent in women who reached menopausal age or have had ovariectomy and in men and women subjected to anti-estrogen therapy. Hormone replacement therapy alleviates menopause symptoms; however, it can increase cardiovascular and cancer diseases. In the search for therapeutic alternatives, medicinal plants and specific synthetic and natural molecules with estrogenic effects have attracted widespread attention between the public and the scientific community. Various plants have been used for centuries to alleviate menstrual and menopause symptoms, such as Cranberry, Ginger, Hops, Milk Thistle, Red clover, Salvia officinalis, Soy, Black cohosh, Turnera diffusa, Ushuva, and Vitex. This review aims to highlight current evidence about estrogenic medicinal plants and their pharmacological effects on cognitive deficits induced by estrogen deficiency during menopause and aging.
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Gene expression analysis of Alzheimer's disease mouse brains exhibited that phytoestrogens were neuroprotective by unwanted signals flanked by ERβ and GSK3β.
“The mechanism of action through gene expression analysis of AD mouse brains exhibited that phytoestrogens were neuroprotective by the unwanted signals flanked by the ER 𝛽 and glycogen synthase kinase 3 (GSK3 𝛽) [81] .”
From Phytotherapy: A promising approach for the treatment of Alzheimer's disease (2022) · cites this paper as [81]
Salvia lavandulaefolia essential oil (0.01 mg/ml) and geraniol (0.1-2 mM) demonstrate possible estrogenic activity via initiation of beta-galactosidase action in yeast cells.
“A possible EA was demonstrated through the initiation of 𝛽-galactosidase action in yeast cells transmitting a promoter promoted by estrogenic compounds exhibited by the essential oil of Spanish sage (0.01 mg/ml) and its modified terpene component geraniol (0.1-2 mM) [81]”
From Phytotherapy: A promising approach for the treatment of Alzheimer's disease (2022) · cites this paper as [81]
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Ajayi, C., Funso-Babarimisa, F., & Elujoba, A. (2014) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.4314/ajtcam.v11i4.7 · Cited by 14 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Apaydin H. l. Ertan S. Ozekmekci S. (2000). Broad Bean (Vicia faba)?A Natural Source ofL-dopa?Prolongs ?on? Periods in Patients with Parkinson's Disease Who Have ?on-Off? Fluctuations. Mov. Disord. 15 (1), 164– 166. 10.1002/1531-825710.1002/1531-8257(200001)15:1<164::aid-mds1028>3.0.co;2-e 10634260 · DOI
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Cited by
Sorted by citations
Phytotherapy: A promising approach for the treatment of Alzheimer's disease
John, O. O., Amarachi, I. S., Chinazom, A. P., Adaeze, E., Kale, M. B., Umare, M. D., & Upaganlawar, A. B. (2022) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2021.100030 · Cited by 69 · see citing works
- Authors
- Echeverria, V., Echeverria, F., Barreto, G. E., Echeverría, J., & Mendoza, C.
- Affiliations
- Universidad San Sebastián (CL)
- University of Limerick (IE)
- Universidad de Santiago de Chile (CL)
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2021-05-20
- Volume
- 12
- Pages
- 644103-644103
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC8172769
- OpenAlex
- W3162653969
- Cited by
- 52
- References
- 228
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 9 · 2023: 15 · 2022: 8 · 2021: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Limerick Institutional Repository (University of Limerick) (acceptedVersion, cc-by-nc-sa)
- University of Limerick Institutional Repository (University of Limerick) (acceptedVersion, other-oa)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by-nc-sa)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion, cc-by)
- University of Limerick Institutional Repository (University of Limerick)
- Funders
- Fondo Nacional de Desarrollo Científico y Tecnológico
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- menopause, estrogen deficiency, neurodegeneration, memory loss, cognitive impairment, ovariectomy, hormone replacement therapy, antiestrogen therapy, hot flashes, mood disorders, sleep disorders, black cohosh, red clover, soybean, cranberry, Humulus lupulus, Silybum marianum, Salvia officinalis, Turnera diffusa, Vitex, brain homeostasis, aging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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