Effect of essential oils and isolated compounds from Pimpinella species on NF‐ κ B: a target for antiinflammatory therapy
Abstract
Pimpinella essential oils and isolated compounds were screened for their inhibitory activity against NF-kappaB mediated transcription in SW1353 cells. Twelve oils were effective in inhibiting NF-kappaB mediated transcription. Especially the roots of P. corymbosa, P. tragium and P. rhodanta showed potent activities with IC(50) values of 2, 3 and 6 microg/mL, respectively. Five pure compounds, 7 (4-(2-propenyl)phenylangelate), 12 (4-(3-methyloxiranyl)phenyltiglate), 17 (4-methoxy-2-(3-methyloxiranyl)phenyl isobutyrate), 18 (4-methoxy-2-(3-methyloxiranyl)phenylangelate) and 21 (epoxy pseudoisoeugenol-2-methylbutyrate) inhibited NF-kappaB mediated transcription with IC(50) values of 5.5, 1.2, 0.01, 3.6 and 11 microg/mL, respectively. None of the compounds were cytotoxic to mammalian cells. These findings add significant information to the pharmacological activity of Pimpinella species and their beneficial effects and use in disease prevention especially those related to inflammation.
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Essential oils of diverse Pimpinella species and their isolates inhibit NF-kB transcription induced by phorbol myristate acetate in SW1353 cells; the most remarkable activity was reported for three Pimpinella species and five pure compounds, and a common epoxyphenylpropanoid moiety is important for the best anti-inflammatory activity.
“The essential oils of diverse Pimpinella species and their isolates were able to inhibit NF-kB transcription induced by phorbol myristate acetate (PMA) in SW1353 cells. However, they did not present similar activities. The most remarkable activity was reported for three Pimpinella species and five pure compounds: Pimpinella corymbosa Boiss., Pimpinella tragium Vill. ssp. polyclada (Boiss. et Heldr”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [146]
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Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
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- Authors
- Tabanca, N., Ma, G., Pasco, D. S., Bedir, E., Kirimer, N., Baser, K. H. C., Khan, I. A., & Khan, S. I.
- Affiliations
- Agricultural Research Service (US)
- University of Mississippi (US)
- Corresponding author
- Khan, Shabana I.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2007-07-17
- Volume
- 21
- Issue
- 8
- Pages
- 741-745
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2069526212
- Cited by
- 41
- References
- 15
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 5 · 2013: 1 · 2012: 3
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- Pimpinella, essential oils, NF-κB inhibition, anti-inflammatory activity, Pimpinella tragium, isobutyrate, SW1353 cells, phytochemicals
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Chlorocebus aethiops, Gene Expression Regulation, Humans, Phytotherapy, Oils, Volatile, Plant Oils, Species Specificity, Molecular Structure, NF-kappa B, Plant Roots, Pimpinella, Plant Components, Aerial
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