Essential oils from Distichoselinum tenuifolium: chemical composition, cytotoxicity, antifungal and anti-inflammatory properties
Open accessAbstract
Ethnopharmacological relevance Several aromatic plants and their essential oils are known to possess antimicrobial and anti-inflammatory properties. Distichoselinum tenuifolium (Lag.) Garcia Martin & Silvestre, an Iberian endemism, is traditionally used in the treatment of contact dermatitis and skin infections. However, the cellular mechanisms through which this plant exerts their beneficial effects are not known.Aim of the study The aims of this study were to examine the chemical composition of the essential oil isolated from Distichoselinum tenuifolium, and to test the efficacy of the essential oil as an antifungal and anti-inflammatory potential.Materials and methods The oils were investigated by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) and the antifungal activity (minimal inhibitory concentrations: MIC and minimal lethal concentrations: MLC) were evaluated against yeasts, dermatophyte and Aspergillus strains. Assessment of cell viability was made by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and the in vitro anti-inflammatory potential of Distichoselinum tenuifolium oil was evaluated by measuring nitric oxide (NO) production induced by LPS, in the absence or in the presence of the oil, in a mouse macrophage cell line.Results The oils are predominantly composed of monoterpene hydrocarbons, being myrcene the main compound (47.7-84.6%). The oils revealed significant antifungal activity against Cryptococcus neoformans and dermatophyte strains and significantly inhibited NO production stimulated by LPS in macrophages, without affecting cell viability at concentrations ranging from 0.64 microL/mL to 1.25 microL/mL.Conclusion These findings add significant information to the pharmacological activity of Distichoselinum tenuifolium essential oils, specifically to its antifungal and anti-inflammatory properties, thus justifying and reinforcing the use of this plant on traditional medicine. Therefore, their beneficial effects and use in disease prevention, especially those related to fungal infections and inflammation, should be explored in more depth.
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Distichoselinum tenuifolium oil significantly inhibits LPS-stimulated NO production in macrophages.
“or the oil of Distichoselinum tenuifolium (Lag.) Garcia Martin & Silvestre, mainly composed by myrcene, that significantly inhibited NO production stimulated by LPS in macrophages, demonstrating, therefore, in vitro anti-inflammatory properties [141].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [141]
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Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
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“myrcene, that significantly inhibited NO production stimulated by LPS in macrophages, demonstrating, therefore, in vitro anti-inflammatory properties [141].”
Background
- Authors
- Tavares, A. C., Gonçalves, M. J., Cruz, M. T., Cavaleiro, C., Lopes, M. C., Canhoto, J., & Salgueiro, L. R.
- Affiliations
- University of Coimbra (PT)
- Centro de Estudos Farmaceuticos (PT)
- Centro de Neurociências e Biologia Celular (PT)
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 130
- Issue
- 3
- Pages
- 593-598
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2032409397
- Cited by
- 57
- References
- 26
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Funders
- Universidade de Coimbra
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant chemical constituents analysis
- Keywords
- essential oils, chemical composition, myrcene, monoterpene hydrocarbons, antifungal activity, anti-inflammatory activity, cytotoxicity, Cryptococcus neoformans, dermatophytes, Aspergillus, nitric oxide production, macrophages, lipopolysaccharide-induced inflammation, contact dermatitis, traditional medicine, fungal infection
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antifungal Agents, Cell Line, Cell Survival, Fungi, Inflammation, Macrophages, Gas Chromatography-Mass Spectrometry, Medicine, Traditional, Microbial Sensitivity Tests, Nitric Oxide, Oils, Volatile, Portugal, Apiaceae, Mice
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