Effects of Athamanta turbith fruit essential oils on CCl4‐induced hepatic failure in mice and their antioxidant properties
Abstract
The effects of essential oils isolated from mature fruits of Athamanta turbith ssp. hungarica (Borbás) Tutin and A. turbith ssp. haynaldii (Borbás & Uechtr.) Tutin (Umbelliferae) on some liver biochemical parameters in mice intoxicated with carbon tetrachloride were investigated. Pretreatment with both essential oils extenuated the effects caused by carbon tetrachloride. In order to investigate in vitro antioxidant properties of the oils, three methods were applied: scavenging of both 2,2-diphenyl-1-picrylhydrazyl (DPPH) and OH radicals, as well as a test of inhibition of Fe(2+)/ascorbic-induced lipid peroxidation. Investigated essential oils exhibited modest antioxidant capacity. Therefore, their influence on biochemical parameters in intoxicated animals might be linked to the inhibition of enzymes (cytochrome P450 2E1) involved in metabolic activation of halomethanes.
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Athamanta turbith ssp. hungarica and ssp. haynaldii oils had similar hydroxyl radical scavenging; by DPPH, ssp. hungarica was most effective but less than quercetin and ascorbic acid.
“The capacity for scavenging hydroxyl radicals was evaluated and the authors found that both oils had similar ability. When the activity was evaluated by the DPPH method, the authors reported that Athamanta turbith ssp. hungarica was the most effective, albeit with less ability than the references used (quercetin and ascorbic acid) [84].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [84]
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Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
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Application of essential oils as antioxidant agents
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- Authors
- Ana, T., Biljana, B., Isidora, S., Marina, M., Neda, M., & Silvana, P.
- Affiliations
- University of Belgrade (RS)
- University of Novi Sad (RS)
- ORCID
- Neda, Mimica‐Dukić
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2009-11-19
- Volume
- 24
- Issue
- 5
- Pages
- 787-790
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2116700261
- Cited by
- 4
- References
- 14
- Citations by year
- 2024: 1 · 2020: 1 · 2018: 1
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- FarFar - Pharmacy Repository (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- essential oils, fruit essential oil, carbon tetrachloride, hepatotoxicity, liver failure, antioxidant activity, DPPH radical scavenging, hydroxyl radical scavenging, lipid peroxidation inhibition, CYP2E1, Apiaceae
- MeSH terms
- Animals, Antioxidants, Biphenyl Compounds, Carbon Tetrachloride, Fruit, Liver, Male, Oils, Volatile, Picrates, Plant Oils, Lipid Peroxidation, Free Radical Scavengers, Liver Failure, Hydroxyl Radical, Apiaceae, Mice
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