Hepatoprotective Effect of Myristicin from Nutmeg ( Myristica fragrans ) on Lipopolysaccharide/ d -Galactosamine-Induced Liver Injury
Abstract
To evaluate the hepatoprotective activity of spices, 21 different spices were fed to rats with liver damage caused by lipopolysaccharide (LPS) plus d-galactosamine (D-GalN). As assessed by plasma aminotranferase activities, nutmeg showed the most potent hepatoprotective activity. Bioassay-guided isolation of the active compound from nutmeg was carried out in mice by a single oral administration of the respective fractions. Myristicin, one of the major essential oils of nutmeg, was found to possess extraordinarily potent hepatoprotective activity. Myristicin markedly suppressed LPS/D-GalN-induced enhancement of serum TNF-alpha concentrations and hepatic DNA fragmentation in mice. These findings suggest that the hepatoprotective activity of myristicin might be, at least in part, due to the inhibition of TNF-alpha release from macrophages. However, further studies are needed to elucidate the hepatoprotective mechanism(s) of myristicin.
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Among 21 spices tested for hepatoprotective activity in rats with LPS/D-galactosamine liver damage, only myristicin presented potent hepatoprotective activity by suppressing LPS/D-GalN-induced enhancement of serum TNF-α concentrations and hepatic DNA fragmentation in mice.
“Among the 21 spices [allspice (Pimenta officinalis Lindl.), cardamom (Elettaria cardamomum Maton.), caraway (Carum carvi L.), gardenia (Gardenia jasminoides Ellis), cumin (Cuminum cyninum L.), clove [Syzygium aromaticum (L.) Merr. & L. M. Perry], laurel (Laurus nobilis L.), coriander (Coriandrum sativum L.), fenugreek (Trigonella foenum-graecum L.), cinnamon (Cinnamomum zeylonicum Blume), sage (”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [122]
Myristicin's hepatoprotective activity might be at least in part due to inhibition of TNF-α release from macrophages.
“Therefore, the hepatoprotective activity of myristicin might be, at least in part, due to the inhibition of TNF-α release from macrophages, according to the same authors [122].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [122]
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Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
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- Authors
- Morita, T., Jinno, K., Kawagishi, H., Arimoto, Y., Suganuma, H., Inakuma, T., & Sugiyama, K.
- Affiliations
- Shizuoka University (JP)
- Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Shizuoka 422-8529, Japan, and Research Institute, Kagome Company, Ltd., 17 Nishitomiyama, Nishinasuno-machi, Nasu-gun, Tochigi 329-2762, Japan
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-02-07
- Volume
- 51
- Issue
- 6
- Pages
- 1560-1565
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2035810813
- Cited by
- 197
- References
- 7
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 10 · 2023: 9 · 2022: 10 · 2021: 12 · 2020: 13 · 2019: 11 · 2018: 9 · 2017: 9 · 2016: 12 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 11
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal plant effects and applications
- Keywords
- myristicin, nutmeg, hepatoprotection, lipopolysaccharide, D-galactosamine, liver injury, TNF-α, macrophages, essential oils, spices, transaminases
- MeSH terms
- Allylbenzene Derivatives, Alanine Transaminase, Animals, Aspartate Aminotransferases, Benzyl Compounds, Diet, Dioxolanes, Galactosamine, Lipopolysaccharides, Liver, Liver Diseases, Male, Oils, Volatile, Pyrogallol, Tumor Necrosis Factor-alpha, Rats, Wistar, Myristica, Mice, Rats, DNA Fragmentation, Chemical and Drug Induced Liver Injury
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