The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Reduction of lipid accumulation in HepG2 Cells by luteolin is associated with activation of AMPK and Mitigation of oxidative stress
Abstract
The present study was carried out to investigate the lipid‐lowering effect of luteolin by using a cell model of steatosis induced by palmitate. Incubation of HepG2 cells with palmitate markedly increased lipid accumulation (Oil Red O staining), the genes involved in lipogenesis, including fatty acid synthase (FAS) and its upstream regulator sterol regulatory element binding protein 1c (SREBP‐1c), and reactive oxygen species (ROS) production. Luteolin enhanced the phosphorylation of AMP‐activated protein kinase α (AMPKα) and its primary downstream targeting enzyme, acetyl‐CoA carboxylase (ACC), up‐regulated gene expression of carnitine palmitoyl transferase 1 (CPT‐1), which is the rate‐limiting enzyme in mitochondrial fatty acid β‐oxidation, and down‐regulated SREBP‐1c and FAS mRNA levels in the absence and presence of palmitate. In addition, luteolin significantly decreased ROS production and ameliorated lipid accumulation in HepG2 cells caused by palmitate. Furthermore, intracellular triglyceride (TG) measurement indicated that the luteolin‐mediated reduction of enhanced TG caused by palmitate was blocked by pretreatment with the AMPK inhibitor, compound C. The results suggested that the lipid‐lowering effect of luteolin might be partially mediated by the up‐regulation of CPT‐1 and down‐regulation of SREBP‐1c and FAS gene expression, possibly by activation of the AMPK signaling pathway, and partially might be through its antioxidative actions. Copyright © 2010 John Wiley & Sons, Ltd.
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Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
The Mitochondrial Carnitine Palmitoyltransferase System — From Concept to Molecular Analysis
McGarry, J. D., & Brown, N. F. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00001.x · Cited by 1,616 · cited 3×
“In addition, inactivation of ACC reduces the synthesis of malonyl-CoA, which in turn de-represses carnitine palmitoyl transferase 1 (CPT-1) and activates fatty acid oxidation (McGarry and Brown, 1997).”
BackgroundInfluentialDistribution and biological activities of the flavonoid luteolin
Lopez-Lazaro, M. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955709787001712 · Cited by 1,106
Speakman, J. R., Talbot, D. A., Selman, C., Snart, S., McLaren, J. S., Redman, P., Krol, E., Jackson, D. M., Johnson, M. S., & Brand, M. D. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00097.x · Cited by 761
Nakamura, S., Takamura, T., Matsuzawa-Nagata, N., Takayama, H., Misu, H., Noda, H., Nabemoto, S., Kurita, S., Ota, T., Ando, H., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901488200 · Cited by 426
Cited by
Luteolin, a flavonoid, as an anticancer agent: A review
Imran, M., Rauf, A., Abu-Izneid, T., Nadeem, M., Shariati, M. A., Khan, I. A., Imran, A., Orhan, I. E., Rizwan, M., Atif, M., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108612 · Cited by 931
Shen, C., Jiang, J., Yang, L., Wang, D., & Zhu, W. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13631 · Cited by 344
Zelber‐Sagi, S., Salomone, F., & Mlynarsky, L. (2017) · Liver International · doi:10.1111/liv.13435 · Cited by 273
ALKHATATBEH, M. J., LINCZ, L. F., & THORNE, R. F. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3069 · Cited by 44
Metadata
- Authors
- Liu, J., Ma, Y., Wang, Y., Du, Z., Shen, J., & Peng, H.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2010-10-05
- Volume
- 25
- Issue
- 4
- Pages
- 588-596
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2108889231
- Cited by
- 168
- References
- 7
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- closed
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