Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer

DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION

Gornall, A. G., Bardawill, C. J., & David, M. M. (1949) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)57021-6 · Cited by 16,164 · see citing works

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

The Free Radical Theory of Aging Matures

BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879 · see citing works

Mitochondrial free radical generation, oxidative stress, and aging

Cadenas, E., & Davies, K. J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00317-8 · Cited by 3,010 · see citing works

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

Boveris, A., & Chance, B. (1973) · Biochemical Journal · doi:10.1042/bj1340707 · Cited by 2,626 · see citing works

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

Korshunov, S. S., Skulachev, V. P., & Starkov, A. A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01159-9 · Cited by 1,727 · see citing works

The cellular production of hydrogen peroxide

Boveris, A., Oshino, N., & Chance, B. (1972) · Biochemical Journal · doi:10.1042/bj1280617 · Cited by 1,549 · see citing works

Topology of superoxide production from different sites in the mitochondrial electron transport chain

St-Pierre, J., Buckingham, J. A., Roebuck, S. J., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207217200 · Cited by 1,545 · see citing works

Superoxide activates mitochondrial uncoupling proteins

Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature · doi:10.1038/415096a · Cited by 1,382 · see citing works

Living fast and dying young: A comparative analysis of life‐history variation among mammals

Promislow, D., & Harvey, P. (1990) · Journal of Zoology · doi:10.1111/j.1469-7998.1990.tb04316.x · Cited by 1,181 · see citing works

Dwarf mice and the ageing process

Brown‐Borg, H. M., Borg, K. E., Meliska, C. J., & Bartke, A. (1996) · Nature · doi:10.1038/384033a0 · Cited by 1,091 · see citing works

ENERGETICS OF FREE-RANGING MAMMALS, REPTILES, AND BIRDS

Nagy, K. A., Girard, I. A., & Brown, T. K. (1999) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.19.1.247 · Cited by 806 · see citing works

Uncoupling to survive? The role of mitochondrial inefficiency in ageing

Brand, M. D. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00135-2 · Cited by 789 · see citing works

Energy metabolism in uncoupling protein 3 gene knockout mice

Vidal-Puig, A. J., Grujic, D., Zhang, C.-Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Wade, J., Mootha, V., Cortright, R., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910179199 · Cited by 677 · see citing works

The Rate of Living.

Wright, S., & Pearl, R. (1928) · Journal of the American Statistical Association · doi:10.2307/2276751 · Cited by 676 · see citing works

A signalling role for 4‐hydroxy‐2‐nonenal in regulation of mitochondrial uncoupling

Echtay, K. S., Esteves, T. C., Pakay, J. L., Jekabsons, M. B., Lambert, A. J., Portero‐Otín, M., Pamplona, R., Vidal‐Puig, A. J., Wang, S., Roebuck, S. J., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg412 · Cited by 597 · see citing works

Mitochondrial Oxygen Radical Generation and Leak: Sites of Production in States 4 and 3, Organ Specificity, and Relation to Aging and Longevity

Barja, G. (1999) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005427919188 · Cited by 494 · see citing works

Regulation of brain mitochondrial H 2 O 2 production by membrane potential and NAD(P)H redox state

Starkov, A. A., & Fiskum, G. M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01908.x · Cited by 491 · see citing works

Mammalian Aging, Metabolism, and Ecology: Evidence From the Bats and Marsupials

Austad, S. N., & Fischer, K. E. (1991) · Journal of Gerontology · doi:10.1093/geronj/46.2.b47 · Cited by 467 · see citing works

Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer

Navarro, A., Gómez, C., López-Cepero, J. M., & Boveris, A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00208.2003 · Cited by 464 · see citing works

Aging and acute exercise enhance free radical generation in rat skeletal muscle

Bejma, J., & Ji, L. L. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.1.465 · Cited by 445 · see citing works

Lack of Obesity and Normal Response to Fasting and Thyroid Hormone in Mice Lacking Uncoupling Protein-3

Gong, D., Monemdjou, S., Gavrilova, O., Leon, L. R., Marcus‐Samuels, B., Chou, C. J., Everett, C. A., Kozak, L. P., Li, C., Deng, C., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910177199 · Cited by 385 · see citing works

Oxidative stress in athletes during extreme endurance exercise

Mastaloudis, A., Leonard, S. W., & Traber, M. G. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00667-0 · Cited by 352 · see citing works

Contractile activity-induced oxidative stress: cellular origin and adaptive responses

McArdle, A., Pattwell, D. M., Vasilaki, A., Griffiths, R. D., & Jackson, M. J. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.3.c621 · Cited by 349 · see citing works

Mitochondrial membrane potential and aging

Nicholls, D. G. (2003) · Aging Cell · doi:10.1111/j.1474-9728.2003.00079.x · Cited by 347 · see citing works

Exercise, free radicals and oxidative stress

Cooper, C. E., Vollaard, N. B. J., Choueiri, T., & Wilson, M. T. (2002) · Biochemical Society Transactions · doi:10.1042/bst0300280 · Cited by 312 · see citing works

Increased Daily Work Precipitates Natural Death in the Kestrel

Daan, S., Deerenberg, C. M., & Dijkstra, C. (1996) · Journal of Animal Ecology · doi:10.2307/5734 · Cited by 312 · see citing works

Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate

Voorhies, W. A. V., & Ward, S. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11399 · Cited by 282 · see citing works

Lifespan Extension and Rescue of Spongiform Encephalopathy in Superoxide Dismutase 2 Nullizygous Mice Treated with Superoxide Dismutase–Catalase Mimetics

Melov, S., Doctrow, S. R., Schneider, J. A., Haberson, J., Patel, M., Coskun, P. E., Huffman, K. D., Wallace, D. C., & Malfroy, B. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08348.2001 · Cited by 277 · see citing works

Das Problem der Lebensdauer und seine Beziehungen zu Wachstum und Ernährung

Rubner, M. H. (1908) · De Gruyter eBooks · doi:10.1515/9783486736380 · Cited by 271 · see citing works

The proton leak across the mitochondrial inner membrane

Brand, M. D. (1990) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(90)90232-s · Cited by 261 · see citing works

Characteristics of mitochondrial proton leak and control of oxidative phosphorylation in the major oxygen-consuming tissues of the rat

Rolfe, D. F. S., Hulbert, A. J., & Brand, M. D. (1994) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(94)90062-0 · Cited by 243 · see citing works

Genetic mouse models of extended lifespan

Liang, H., Masoro, E. J., Nelson, J. F., Strong, R., McMahan, C. A., & Richardson, A. G. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.019 · Cited by 236 · see citing works

Mitochondria: are they the seat of senescence?

Fridovich, I. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00075.x · Cited by 230 · see citing works

O2 solubility in aqueous media determined by a kinetic method

Reynafarje, B., Costa, L. E., & Lehninger, A. L. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90381-1 · Cited by 226 · see citing works

Comparative biology of aging in birds: an update

Holmes, D. J., Flückiger, R., & Austad, S. N. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00247-3 · Cited by 224 · see citing works

Living Fast, Dying When? The Link between Aging and Energetics

Speakman, J. R., Selman, C., McLaren, J. S., & Harper, E. J. (2002) · Journal of Nutrition · doi:10.1093/jn/132.6.1583s · Cited by 216 · see citing works

Limits to sustained energy intake

Johnson, M. S., Thomson, S. C., & Speakman, J. R. (2001) · Journal of Experimental Biology · doi:10.1242/jeb.204.11.1947 · Cited by 208 · see citing works

Oxidative stress and mitochondrial function with aging – the effects of calorie restriction

Merry, B. J. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00074.x · Cited by 207 · see citing works

Free radical generation and oxidative stress with ageing and exercise: Differential effects in the myocardium and liver

Bejma, Ramires, J. A. F., & Ji (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00745.x · Cited by 203 · see citing works

Energy metabolism and aging: a lifelong study of Fischer 344 rats

McCarter, R., & Palmer, J. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.3.e448 · Cited by 202 · see citing works

Restriction of energy intake, energy expenditure, and aging

Ramsey, J. J., Harper, M., & Weindruch, R. H. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00417-2 · Cited by 202 · see citing works

A History of the First Uncoupling Protein, UCP1

Nicholls, D. G., & Rial, E. (1999) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005436121005 · Cited by 201 · see citing works

Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies

Marden, J. H., Rogina, B., Montooth, K. L., & Helfand, S. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0634985100 · Cited by 201 · see citing works

The Effects of Acute Exercise on Neutrophils and Plasma Oxidative Stress

Quindry, J. C., Stone, W. L., KING, J., et al. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000074568.82597.0b · Cited by 179 · see citing works

Comparative aging and life histories in mammals

Austad, S. N. (1997) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00059-9 · Cited by 176 · see citing works

Mammalian Metabolism and Life Histories

Harvey, P., Pagel, M. D., & Rees, J. A. (1991) · The American Naturalist · doi:10.1086/285183 · Cited by 166 · see citing works

Age‐related changes in the metabolism and body composition of three dog breeds and their relationship to life expectancy

Speakman, J. R., Van Acker, A., & Harper, E. J. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00061.x · Cited by 156 · see citing works

Relationship between oxygen metabolism, aging and development

Sohal, R. S., & Allen, R. G. (1986) · Advances in free radical biology and medicine · doi:10.1016/s8755-9668(86)80026-6 · Cited by 152 · see citing works

Uncoupling the agony from ecstasy

Mills, E., Banks, M. L., Sprague, J. E., & Finkel, T. (2003) · Nature · doi:10.1038/426403a · Cited by 148 · see citing works

Experimental evidence against the mitochondrial theory of aging A study of isolated human skeletal muscle mitochondria

Rasmussen, U. F., Krustrup, P., Kjær, M., & Rasmussen, H. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00092-5 · Cited by 132 · see citing works

Limits to sustained energy intake

Johnson, M. S., Thomson, S. C., & Speakman, J. R. (2001) · Journal of Experimental Biology · doi:10.1242/jeb.204.11.1937 · Cited by 117 · see citing works

Longevity of cold-exposed rats: a reevaluation of the "rate-of-living theory"

Holloszy, J. O., & Smith, E. K. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.61.5.1656 · Cited by 116 · see citing works

Uncoupling Protein—A Useful Energy Dissepator

Klingenberg, M. (1999) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005440221914 · Cited by 116 · see citing works

Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins

Yan, L., & Sohal, R. S. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00423-8 · Cited by 115 · see citing works

Oxidative stress hypothesis of aging 1,2 1Guest Editor: Rajindar S. Sohal 2This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal.

Sohal, R. S. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00885-7 · Cited by 113 · see citing works

Effect of voluntary exercise on H2O2 release by subsarcolemmal and intermyofibrillar mitochondria

Servais, S. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00177-1 · Cited by 111 · see citing works

EPR spectroscopic detection of free radical outflow from an isolated muscle bed in exercising humans

Bailey, D. M., Davies, B., Young, I. S., Jackson, M. J., Davison, G. W., Isaacson, R. A., & Richardson, R. S. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01024.2002 · Cited by 100 · see citing works

Measurement of mitochondrial protonmotive force

Brand, M. D. (1995) · doi:10.1093/oso/9780199634897.003.0003 · Cited by 96 · see citing works

Extra Loads and Foraging Life Span in Honeybee Workers

Wolf, T. J., & Schmid‐Hempel, P. (1989) · Journal of Animal Ecology · doi:10.2307/5134 · Cited by 95 · see citing works

Isotope dilution spaces of mice injected simultaneously with deuterium, tritium and oxygen-18

Król, E., & Speakman, J. R. (1999) · Journal of Experimental Biology · doi:10.1242/jeb.202.20.2839 · Cited by 81 · see citing works

Age‐specific metabolic rates and mortality rates in the genus Drosophila

Promislow, D., & Haselkorn, T. S. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00009.x · Cited by 78 · see citing works

Antioxidant status and stress resistance in long- and short-lived lines of Drosophila melanogaster

Mockett, R. J., Orr, W. C., Rahmandar, J. J., et al. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00258-8 · Cited by 78 · see citing works

Assessing metabolic activity in aging Caenorhabditis elegans : concepts and controversies

Braeckman, B. P., Houthoofd, K., & Vanfleteren, J. R. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00021.x · Cited by 76 · see citing works

Ageing and the mystery at Arles

Nemoto, S., & Finkel, T. (2004) · Nature · doi:10.1038/429149a · Cited by 74 · see citing works

Ambient temperature, physical activity and aging in the housefly, Musca domestica

Ragland, S. S., & Sohal, R. S. (1975) · Experimental Gerontology · doi:10.1016/0531-5565(75)90005-4 · Cited by 74 · see citing works

Mechanism of uncoupling protein action

Garlid, K., Jabůrek, M., & Ježek, P. (2001) · Biochemical Society Transactions · doi:10.1042/0300-5127:0290803 · Cited by 69 · see citing works

The pH‐dependent reciprocal changes in contributions of ADP/ATP antiporter and aspartate/glutamate antiporter to the fatty acid‐induced uncoupling

Samartsev, V. N., MOKHOVA, E. N., & Skulachev, V. P. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00667-4 · Cited by 65 · see citing works

Mechanism of uncoupling protein action

Garlid, K., Jabůrek, M., & Ježek, P. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290803 · Cited by 64 · see citing works

Antioxidant enzyme activities, lipid peroxidation, and DNA oxidative damage: the effects of short-term voluntary wheel running

Selman, C., McLaren, J. S., Collins, A. R., Duthie, G. G., & Speakman, J. R. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00050-4 · Cited by 63 · see citing works

Mitochondrial Bioenergetics, Aging, and Aging-Related Disease

Nicholls, D. G. (2002) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.31.pe12 · Cited by 58 · see citing works

Selected Contribution: Long-lived Drosophila melanogaster lines exhibit normal metabolic rates

Voorhies, W. A. V., Khazaeli, A. A., & Curtsinger, J. W. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00448.2003 · Cited by 52 · see citing works

Effects of magnesium and nucleotides on the proton conductance of rat skeletal-muscle mitochondria

Cadenas, S., & Brand, M. D. (2000) · Biochemical Journal · doi:10.1042/bj3480209 · Cited by 50 · see citing works

Relation of lifespan to brain weight, body weight, and metabolic rate among inbred mouse strains

Storer, J. B. (1967) · Experimental Gerontology · doi:10.1016/0531-5565(67)90033-2 · Cited by 49 · see citing works

Uncoupling protein, H+ transport and regulation

Klingenberg, M., Winkler, E., & Echtay, K. S. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290806 · Cited by 45 · see citing works

Reactive oxygen species in pregnant rats: effects of exercise and thermal stress

Osorio, R., Christofani, J. S., D’Almeida, V., Russo, A. K., & Piçarro, I. C. (2003) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(03)00078-4 · Cited by 32 · see citing works

Mitochondria, reactive oxygen species and longevity: some lessons from the Barja group

Skulachev, V. P. (2003) · Aging Cell · doi:10.1111/j.1474-9728.2003.00076.x · Cited by 26 · see citing works

Metabolism and aging in the nematode Caenorhabditis elegans1,2 1Guest Editor: Rajindar S. Sohal 2This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal.

Voorhies, W. A. V. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00965-6 · Cited by 21 · see citing works

Limits to sustained energy intake II. Inter-relationships between resting metabolic rate, life-history traits and morphology in Mus musculus

Johnson, M. S., Thomson, S. C., & Speakman, J. R. (2001) · Aberdeen University Research Archive (Aberdeen University) · Cited by 16 · see citing works

What do we not know of cellular bioenergetics? — a general view on the state of the art

Saks, V. A., Ventura‐Clapier, R., Leverve, X. M., et al. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5653-4_1 · Cited by 13 · see citing works

Rebuttal to Van Voorhies: ‘The influence of metabolic rate on longevity in the nematode Caenorhabditis elegans’

Braeckman, B. P., Houthoofd, K., & Vanfleteren, J. R. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00023.x · Cited by 7 · see citing works

Dose translation from animal to human studies revisited.

Reagan‐Shaw, S., Nihal, M., & Ahmad, N. (2008) · The FASEB Journal · doi:10.1096/fj.07-9574lsf · Cited by 6,524 · see citing works

Mitochondria, Oxidants, and Aging

Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

Schulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., & Ristow, M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.011 · Cited by 1,209 · see citing works

Body size, energy metabolism and lifespan

Speakman, J. R. (2005) · Journal of Experimental Biology · doi:10.1242/jeb.01556 · Cited by 914 · see citing works

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

Passos, J. F., Saretzki, G., Ahmed, S., Nelson, G., Richter, T., Peters, H., Wappler, I., Birket, M. J., Harold, G., Schaeuble, K., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050110 · Cited by 796 · see citing works

Calorie restriction–the SIR2 connection

Guarente, L., & Picard, F. (2005) · Cell · doi:10.1016/j.cell.2005.01.029 · Cited by 793 · see citing works

SIRT1 transgenic mice show phenotypes resembling calorie restriction

Bordone, L., Cohen, D., Robinson, A., Motta, M. C., Van Veen, E., Czopik, A., Steele, A. D., Crowe, H., Marmor, S., Luo, J., et al. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00335.x · Cited by 722 · see citing works

Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

Bordone, L., Motta, M. C., Picard, F., Robinson, A., Jhala, U. S., Apfeld, J., McDonagh, T., Lemieux, M., McBurney, M., Szilvasi, A., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0040031 · Cited by 715 · see citing works

SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes

Shi, T., Wang, F., Stieren, E., & Tong, Q. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414670200 · Cited by 712 · see citing works

Interventions to slow aging in humans: are we ready?

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592 · see citing works

Resveratrol and health—A comprehensive review of human clinical trials

Smoliga, J. M., Baur, J. A., & Hausenblas, H. A. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100143 · Cited by 594 · see citing works

Mitochondrial uncoupling, ROS generation and cardioprotection

Cadenas, S. (2018) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2018.05.019 · Cited by 591 · see citing works

To Scale or Not to Scale: The Principles of Dose Extrapolation

Sharma, V., & McNeill, J. H. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00267.x · Cited by 544 · see citing works

Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice

Selman, C., Lingard, S., Choudhury, A. I., Batterham, R. L., Claret, M., Clements, M., Ramadani, F., Okkenhaug, K., Schuster, E., Blanc, E., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-9261com · Cited by 532 · see citing works

Exercise Promotes Healthy Aging of Skeletal Muscle

Cartee, G. D., Hepple, R. T., Bamman, M. M., & Zierath, J. R. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.007 · Cited by 483 · see citing works

Oxidative stress and aberrant signaling in aging and cognitive decline

Dröge, W., & Schipper, H. M. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00294.x · Cited by 479 · see citing works

Resveratrol is not a direct activator of SIRT1 enzyme activity

Beher, D., Wu, J., Cumine, S., Kim, K. W., Lu, S., Atangan, L., & Wang, M. (2009) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2009.00901.x · Cited by 426 · see citing works

Reduced TOR Signaling Extends Chronological Life Span via Increased Respiration and Upregulation of Mitochondrial Gene Expression

Bonawitz, N. D., Chatenay-Lapointe, M., Pan, Y., & Shadel, G. S. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.009 · Cited by 422 · see citing works

Caloric Restriction, the Traditional Okinawan Diet, and Healthy Aging: The Diet of the World's Longest‐Lived People and Its Potential Impact on Morbidity and Life Span

WILLCOX, B. J., WILLCOX, D. C., TODORIKI, H., FUJIYOSHI, A., YANO, K., HE, Q., CURB, J. D., & SUZUKI, M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1396.037 · Cited by 370 · see citing works

Pten positively regulates brown adipose function, energy expenditure, and longevity

Ortega-Molina, A., Efeyan, A., Lopez-Guadamillas, E., Muñoz-Martin, M., Gómez-López, G., Cañamero, M., Mulero, F., Pastor, J., Martinez, S., Romanos, E., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.001 · Cited by 356 · see citing works

A common brain network links development, aging, and vulnerability to disease

Douaud, G., Groves, A. R., Tamnes, C. K., Westlye, L. T., Duff, E. P., Engvig, A., Walhovd, K. B., James, A., Gass, A., Monsch, A. U., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410378111 · Cited by 317 · see citing works

The secretory function of adipocytes in the physiology of white adipose tissue

Wang, P., Mariman, E., Renes, J., & Keijer, J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21386 · Cited by 318 · see citing works

SIRT6 protects against pathological damage caused by diet‐induced obesity

Kanfi, Y., Peshti, V., Gil, R., Naiman, S., Nahum, L., Levin, E., Kronfeld‐Schor, N., & Cohen, H. Y. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00544.x · Cited by 311 · see citing works

Mitochondrial Approaches for Neuroprotection

Chaturvedi, R. K., & Beal, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.027 · Cited by 294 · see citing works

Dynamic regulation of PGC‐1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

Anderson, R. M., Barger, J. L., Edwards, M. G., Braun, K. H., O’Connor, C. E., Prolla, T. A., & Weindruch, R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00357.x · Cited by 283 · see citing works

The Mediterranean dietary pattern as the diet of choice for non‐alcoholic fatty liver disease: Evidence and plausible mechanisms

Zelber‐Sagi, S., Salomone, F., & Mlynarsky, L. (2017) · Liver International · doi:10.1111/liv.13435 · Cited by 273 · see citing works

Mitochondrial NADPH, transhydrogenase and disease

Rydström, J. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.03.010 · Cited by 256 · see citing works

Of mice and men. When it comes to studying ageing and the means to slow it down, mice are not just small humans

Demetrius, L. (2005) · The EMBO Reports · doi:10.1038/sj.embor.7400422 · Cited by 257 · see citing works

‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue

Pérez, L. M., Pareja‐Galeano, H., Sanchis‐Gomar, F., Emanuele, E., Lucia, A., & Gálvez, B. G. (2016) · The Journal of Physiology · doi:10.1113/jp271691 · Cited by 215 · see citing works

Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria

Bevilacqua, L., Ramsey, J. J., Hagopian, K., Weindruch, R., & Harper, M.-E. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00435.2004 · Cited by 172 · see citing works

Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway

Zhang, Y., Chen, M., Zhou, Y., Yi, L., Gao, Y., Ran, L., Chen, S., Zhang, T., Zhou, X., Zou, D., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500016 · Cited by 170 · see citing works

Mitochondrial uncoupling and lifespan

Mookerjee, S. A., Divakaruni, A. S., Jastroch, M., & Brand, M. D. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.03.010 · Cited by 169 · see citing works

Mitochondrial Proton Leak Plays a Critical Role in Pathogenesis of Cardiovascular Diseases

Cheng, J., Nanayakkara, G., Shao, Y., Cueto, R., Wang, L., Yang, W. Y., Tian, Y., Wang, H., & Yang, X. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-55330-6_20 · Cited by 168 · see citing works

Tipping the metabolic scales towards increased longevity in mammals

Riera, C. E., & Dillin, A. (2015) · Nature Cell Biology · doi:10.1038/ncb3107 · Cited by 153 · see citing works

Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models

Komen, J. C., & Thorburn, D. R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12413 · Cited by 149 · see citing works

Mitochondrial gene expression and increased oxidative metabolism: Role in increased lifespan of fat-specific insulin receptor knock-out mice

Katic, M., Kennedy, A. R., Leykin, I., Norris, A., McGettrick, A., Gesta, S., Russell, S. J., Bluher, M., Maratos‐Flier, E., & Kahn, C. R. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00346.x · Cited by 141 · see citing works

Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants

Park, S., Kim, K., Page, G. P., Allison, D. B., Weindruch, R., & Prolla, T. A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00496.x · Cited by 134 · see citing works

Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men

Olesen, J., Gliemann, L., Biensø, R., Schmidt, J., Hellsten, Y., & Pilegaard, H. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.270256 · Cited by 119 · see citing works

Thyroid Hormone Signaling and Homeostasis During Aging

Bowers, J., Terrien, J., Clerget-Froidevaux, M. S., Gothié, J. D., Rozing, M. P., Westendorp, R. G. J., van Heemst, D., & Demeneix, B. A. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1056 · Cited by 117 · see citing works

Mitochondrial signaling, TOR, and life span

Schieke, S. M., & Finkel, T. (2006) · Biological Chemistry · doi:10.1515/bc.2006.170 · Cited by 106 · see citing works

Delipidating effect of resveratrol metabolites in 3<scp>T</scp>3‐<scp>L</scp>1 adipocytes

Lasa, A., Churruca, I., Eseberri, I., Andrés‐Lacueva, C., & Portillo, M. P. (2012) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.201100772 · Cited by 103 · see citing works

Energy Metabolism and Ageing in the Mouse: A Mini-Review

Azzu, V., & Valencak, T. G. (2017) · Gerontology · doi:10.1159/000454924 · Cited by 90 · see citing works

Neuroprotective Effects of Resveratrol on Damages of Mouse Cortical Neurons Induced by β-amyloid through Activation of SIRT1/Akt1 Pathway

Zhang, J., Feng, X., Wu, J., Xu, H., Li, G., Zhu, D., Yue, Q., Liu, H., Zhang, Y., Sun, D., et al. (2014) · BioFactors · doi:10.1002/biof.1149 · Cited by 50 · see citing works

Sirtuin activation as a therapeutic approach against inborn errors of metabolism

Bleeker, J. C., & Houtkooper, R. H. (2016) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-016-9939-8 · Cited by 11 · see citing works

Energetics, ecological (bioenergetics)

Alexander, D. (2011) · SpringerReference · doi:10.1007/springerreference_29541

Energetics, ecological (bioenergetics)

Alexander, D. E. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-4494-1_107

The human uncoupling protein‐1 gene (UCP1): present status and perspectives in obesity research

González‐Barroso, M. M., Ricquier, D., & Cassard, A. (2000) · Obesity Reviews · doi:10.1046/j.1467-789x.2000.00009.x · Cited by 109 · see citing works

Mitochondrial uncoupling as a target in the treatment of obesity

Costford, S. R., Gowing, A., & Harper, M. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f0dbe4 · Cited by 26 · see citing works

Undecanesulfonate does not allosterically activate H+ uniport mediated by uncoupling protein-1 in brown adipose tissue mitochondria

Ježek, P., Špaček, T., Garlid, K., et al. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.05.011 · Cited by 9 · see citing works