Photoprotective Effects of Topical Formulations Containing a Combination of Ginkgo biloba and Green Tea Extracts
Abstract
The beneficial photoprotective effects of topical formulations containing combined extracts of Ginkgo biloba (GB) and green tea (GT) have not been investigated. The present study aims to assess the photoprotective effects of topical formulations containing GB and GT combined or not by applications on the dorsal skin of hairless mice prior to UVA/B irradiation. After 20 h, skin barrier damage (TEWL), erythema, histological alterations and sunburn cell formation were evaluated. The results showed that only extract supplemented formulations protected the skin against the UV‐induced damage. Formulations containing GB provided total protection of the skin barrier function avoiding UV radiation damage such as TEWL and erythema and were more effective than those containing GT. However, it is suggested that formulations containing combined GB and GT may provide substantial photoprotective effects since different aspects of skin damage were influenced by each extract. Copyright © 2011 John Wiley & Sons, Ltd.
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Belo et al. in vitro study on Ginkgo biloba and green tea extracts was classified as Level 3 evidence and was limited by in vitro design, small sample size, and lack of a control group.
“According to the Oxford Centre for Evidence‐Based Medicine Levels of Evidence, this study would be classified as Level 3: evidence from well‐designed controlled trials without randomization.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [11]
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- Authors
- Belo, S. E. D., Gaspar, L. R., & Campos, P. M. B. G. M.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Campos, Patrícia Maria Berardo Gonçalves Maia
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2011-04-25
- Volume
- 25
- Issue
- 12
- Pages
- 1854-1860
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W1561803985
- Cited by
- 41
- References
- 33
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 5 · 2022: 8 · 2020: 1 · 2019: 4 · 2018: 3 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- photoprotection, Ginkgo biloba extract, green tea extract, topical formulation, skin barrier function, transepidermal water loss, erythema, sunburn cells, skin histopathology, hairless mice
- MeSH terms
- Administration, Cutaneous, Animals, Erythema, Male, Mice, Hairless, Plant Extracts, Skin, Sunburn, Sunscreening Agents, Tea, Ultraviolet Rays, Ginkgo biloba, Mice
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