Toxic effects of ultraviolet radiation on the skin

Matsumura, Yasuhiro; Ananthaswamy, Honnavara N

doi:10.1016/j.taap.2003.08.019

Cited by 1,270Skin Protection and AgingNonmelanoma Skin Cancer StudiesDNA Repair Mechanisms

Toxic effects of ultraviolet radiation on the skin

Matsumura, Yasuhiro, Ananthaswamy, Honnavara N·2004·Toxicology and Applied Pharmacology

DOI 10.1016/j.taap.2003.08.019

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Abstract

Ultraviolet (UV) irradiation present in sunlight is an environmental human carcinogen. The toxic effects of UV from natural sunlight and therapeutic artificial lamps are a major concern for human health. The major acute effects of UV irradiation on normal human skin comprise sunburn inflammation (erythema), tanning, and local or systemic immunosuppression. At the molecular level, UV irradiation causes DNA damage such as cyclobutane pyrimidine dimers and (6-4) photoproducts, which are usually repaired by nucleotide excision repair (NER). Chronic exposure to UV irradiation leads to photoaging, immunosuppression, and ultimately photocarcinogenesis. Photocarcinogenesis involves the accumulation of genetic changes, as well as immune system modulation, and ultimately leads to the development of skin cancers. In the clinic, artificial lamps emitting UVB (280-320 nm) and UVA (320-400 nm) radiation in combination with chemical drugs are used in the therapy of many skin diseases including psoriasis and vitiligo. Although such therapy is beneficial, it is accompanied with undesirable side effects. Thus, UV radiation is like two sides of the same coin--on one side, it has detrimental effects, and on the other side, it has beneficial effects.

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UV radiation and the skin
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Authors: Matsumura, Y., & Ananthaswamy, H. N.
Affiliations: Kansai Medical University (JP)
Corresponding author: Matsumura, Yasuhiro
Venue: Toxicology and Applied Pharmacology
Publisher: Elsevier BV
Published: 2004-03
Volume: 195
Issue: 3
Pages: 298-308
ISSN: 0041-008X (ISSN-L)
DOI: 10.1016/j.taap.2003.08.019
OpenAlex: W2100130506
Cited by: 1,270
References: 105
Citations by year: 2026: 47 · 2025: 55 · 2024: 79 · 2023: 81 · 2022: 74 · 2021: 64 · 2020: 69 · 2019: 72 · 2018: 79 · 2017: 53 · 2016: 65 · 2015: 59 · 2014: 55 · 2013: 68 · 2012: 56
FWCI: 4.16
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Toxicology and Applied Pharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01CA046523, R01-CA46523)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: ultraviolet radiation, skin toxicity, sunburn, erythema, tanning, immunosuppression, DNA damage, cyclobutane pyrimidine dimers, 6-4 photoproducts, nucleotide excision repair, photoaging, photocarcinogenesis, skin cancer, psoriasis treatment, phototherapy adverse effects
MeSH terms: DNA Damage, Humans, Skin, Skin Neoplasms, Ultraviolet Rays, Ultraviolet Therapy

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Toxic effects of ultraviolet radiation on the skin

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