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Cited by 144Ginseng Biological Effects and ApplicationsMedicinal Plants and Bioactive CompoundsGarlic and Onion Studies

Panax ginseng in Randomised Controlled Trials: A Systematic Review

Shergis, Johannah L., Zhang, Anthony L., Zhou, Wenyu, Xue, Charlie C.·2013·Phytotherapy Research
DOI 10.1002/ptr.4832
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Abstract

Panax ginseng C.A. Meyer is a common herb with many purported health benefits. However, there is no conclusive evidence supporting its use in the treatment of any particular disease. We conducted a systematic review to evaluate randomised controlled trials. Four English databases were searched with no publication date restriction. Included studies evaluated P. ginseng in patients with any type of disease or in healthy individuals. We assessed the quality of studies using the Cochrane risk of bias tool. Of the 475 potentially relevant studies, 65 met the inclusion criteria. These studies examined P. ginseng's effects on psychomotor performance (17 studies), physical performance (ten), circulatory system (eight), glucose metabolism (six), the respiratory system (five), erectile dysfunction (four), immunomodulation (four), quality of life/mood (four), antioxidant function (two), cancer (two), menopausal symptoms (two) and dry mouth (one). The risk of bias was unclear in most studies. Authors evaluated adverse events in 40 studies, with 135 minor events and no serious adverse events reported. P. ginseng shows promising results for improving glucose metabolism and moderating the immune response. This may have implications for several diseases including type 2 diabetes and chronic respiratory conditions. Further studies are needed to explore P. ginseng's potential as an effective treatment for these and other health conditions.

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  • In Chinese traditional medicine, ginseng extracts have been used as nootropic agents and as a tonic.

    “In Chinese traditional medicine, ginseng extracts have also been used as nootropic agents and as a tonic [24,25,26].”

    From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [26]

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Authors
Shergis, J. L., Zhang, A. L., Zhou, W., & Xue, C. C.
Affiliations
RMIT University (AU)
Corresponding author
Xue, Charlie C.
ORCID
Venue
Phytotherapy Research
Publisher
Wiley
Published
2012-09-12
Volume
27
Issue
7
Pages
949-965
ISSN
  • 0951-418X (ISSN-L)
  • 1099-1573
DOI
10.1002/ptr.4832
OpenAlex
W1958190914
Cited by
144
References
80
Citations by year
2026: 7 · 2025: 6 · 2024: 7 · 2023: 9 · 2022: 8 · 2021: 20 · 2020: 10 · 2019: 13 · 2018: 15 · 2017: 6 · 2016: 10 · 2015: 8 · 2014: 18 · 2013: 7
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Phytotherapy Research (publishedVersion)
  • PubMed (publishedVersion)
  • RMIT Research Repository (RMIT University Library) (submittedVersion)
Funders
  • Guangdong Provincial Hospital of Traditional Chinese Medicine
  • Academy of Medical Sciences
  • Guangdong Provincial Academy of Chinese Medical Sciences
  • National Health and Medical Research Council
  • National Medical Research Council
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ginseng Biological Effects and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
Keywords
Panax ginseng, ginseng, herbal medicine, psychomotor performance, physical performance, glucose metabolism, immunomodulation, antioxidant function, erectile dysfunction, menopausal symptoms, xerostomia, adverse events, type 2 diabetes, chronic respiratory disease, cancer
MeSH terms
Female, Panax, Humans, Male, Phytotherapy, Randomized Controlled Trials as Topic, Treatment Outcome, Plant Preparations

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