Cited by 106Ginseng Biological Effects and ApplicationsMedicinal Plants and Bioactive CompoundsMedicinal Plants and Neuroprotection

Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults

Reay, Jonathon L., Scholey, Andrew B., Kennedy, David O.·2010·Human Psychopharmacology Clinical and Experimental

Abstract

OBJECTIVE: There is a lack of research into the cognitive and mood effects of repeated ginseng ingestion. The present study assessed the effects of Panax ginseng (G115) on subjective mood and aspects of 'working' memory processes, following a single dose and following sub-chronic (7 days) ingestion, in healthy volunteers. METHODS: A placebo-controlled, double-blind, randomised, crossover was utilised. Thirty volunteers (mean age 22.87 years; SD 4.01) received each treatment (200 mg; 400 mg; placebo) for 8 days, in a counter balanced order, with a 6-day wash-out period. Testing was on days 1 and 8 of each treatment period, at pre-dose, 1, 2.5 and 4 h post-dose. RESULTS: Results revealed dose-related treatment effects (p < 0.05). Two hundred milligrams slowed a fall in mood at 2.5 and 4 h on day 1 and at 1 and 4 h on day 8, but slowed responding on a mental arithmetic task across day 1 and at 1 and 2.5 h on day 8. The 400 mg dose also improved calmness (restricted 2.5 and 4 h on day 1) and improved mental arithmetic across days 1 and 8. CONCLUSIONS: We found no evidence of additional benefits, nor attenuation of acute effects following repeated ingestion of Panax ginseng (G115).

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Crossref · 10.1002/hup.1138

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  • The intake of plant adaptogens is not associated with serious side effects.

    “The intake of plant adaptogens is not associated with serious side effects [20,21].”

    From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [21]

  • The intake of Panax ginseng extract is not associated with serious side effects.

    “The intake of Panax ginseng extract is not associated with serious side effects [21,32,33,34,35,36,37,38,39,40,41].”

    From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [21]

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Authors
Reay, J. L., Scholey, A. B., & Kennedy, D. O.
Affiliations
  • Northumbria University (GB)
  • Swinburne University of Technology (AU)
Corresponding author
Reay, Jonathon L.
Venue
Human Psychopharmacology Clinical and Experimental
Publisher
Wiley
Published
2010-08
Volume
25
Issue
6
Pages
462-471
ISSN
  • 0885-6222 (ISSN-L)
  • 1099-1077
OpenAlex
W2090945566
Cited by
106
References
29
Citations by year
2026: 10 · 2025: 10 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 9 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 6 · 2013: 11 · 2012: 5
FWCI
2.60
Type
journal article
Language
en
Open access
closed
Locations
  • Human Psychopharmacology Clinical and Experimental (publishedVersion)
  • PubMed (publishedVersion)
  • TeesRep (Teesside University) (publishedVersion)
  • Teesside University Research Portal (Teesside University) (submittedVersion)
  • Northumbria Research Link (Northumbria University) (submittedVersion)
  • Swinburne figshare (Swinburne University of Technology) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ginseng Biological Effects and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
Panax ginseng, working memory, subjective mood, tranquility, mental arithmetic, dose-response relationship, healthy young adults
MeSH terms
Affect, Double-Blind Method, Mental Fatigue, Female, Panax, Humans, Male, Memory, Short-Term, Plant Extracts, Cross-Over Studies, Young Adult

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