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Quercetin and EGCG Exhibit Chemopreventive Effects in Cholangiocarcinoma Cells via Suppression of JAK/STAT Signaling Pathway
Abstract
Quercetin and epigallocatechin‐3‐gallate (EGCG) are dietary phytochemicals with antiinflammatory and antitumor effects. In the present study, we examined the effects of these two compounds on Janus‐like kinase (JAK)/signal transduction and transcription (STAT) pathway of cholangiocarcinoma (CCA) cells, because CCA is one of the aggressive cancers with very poor prognosis and JAK/STAT pathway is critically important in inflammation and carcinogenesis. The results showed that the JAK/STAT pathway activation by proinflammatory cytokine interleukin‐6 and interferon‐γ in CCA cells was suppressed by pretreatment with quercetin and EGCG, evidently by a decrease of the elevated phosphorylated‐STAT1 and STAT3 proteins in a dose‐dependent manner. The cytokine‐mediated up‐regulation of inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule‐1 (ICAM‐1) via JAK/STAT cascade was abolished by both quercetin and EGCG pretreatment. Moreover, these flavonoids also could inhibit growth and cytokine‐induced migration of CCA cells. Pretreatment with specific JAK inhibitors, AG490 and piceatannol, abolished cytokine‐induced iNOS and ICAM‐1 expression. These results demonstrate beneficial effects of quercetin and EGCG in the suppression of JAK/STAT cascade of CCA cells. Quercetin and EGCG would be potentially useful as cancer chemopreventive agents against CCA. Copyright © 2013 John Wiley & Sons, Ltd.
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“Quercetin is a phytochemical with antioxidant and neuroprotective activity [40,41,42].”
From Health Benefits and Chemical Composition of Matcha Green Tea: A Review (2020) · cites this paper as [40]
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“Research findings regarding EGCG supplementation also include inhibition of growth and proliferation of gallbladder and bile duct cancer cells, as well as a decreased risk of biliary duct cancer [40,57].”
From Health Benefits and Chemical Composition of Matcha Green Tea: A Review (2020) · cites this paper as [40]
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Cited by
Health Benefits and Chemical Composition of Matcha Green Tea: A Review
Kochman, J., Jakubczyk, K., Antoniewicz, J., Mruk, H., & Janda, K. (2020) · Molecules · doi:10.3390/molecules26010085 · Cited by 328
Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
Kashyap, D., Garg, V. K., Tuli, H. S., Yerer, M. B., Sak, K., Sharma, A. K., Kumar, M., Aggarwal, V., & Sandhu, S. S. (2019) · Biomolecules · doi:10.3390/biom9050174 · Cited by 285
The STAT3 pathway as a therapeutic target in head and neck cancer: barriers and innovations
Geiger, J. L., Grandis, J. R., & Bauman, J. E. (2016) · Oral Oncology · doi:10.1016/j.oraloncology.2015.11.022 · Cited by 193
Kronman, H., Torres-Berrío, A., Sidoli, S., Issler, O., Godino, A., Ramakrishnan, A., Mews, P., Lardner, C. K., Parise, E. M., Walker, D. M., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00814-8 · Cited by 108
Metadata
- Authors
- Senggunprai, L., Kukongviriyapan, V., Prawan, A., & Kukongviriyapan, U.
- Affiliations
- Department of Pharmacology, Faculty of Medicine, and Liver Fluke and Cholangiocarcinoma Research Center Khon Kaen University 40002 Thailand
- Department of Physiology, Faculty of Medicine Khon Kaen University 40002 Thailand
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2013-08-30
- Volume
- 28
- Issue
- 6
- Pages
- 841-848
- ISSN
- 0951-418X
- 1099-1573
- Cited by
- 95
- References
- 1
- Language
- en
- Funders
- Thailand Research Fund (Grant No. MRG5480011)
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- CoChat. (2026). Citation check: Quercetin and EGCG Exhibit Chemopreventive Effects in Cholangiocarcinoma Cells via Suppression of JAK/STAT Signaling Pathway. https://app.cochat.ai/papers/10.1002/ptr.5061
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- Senggunprai, L., Kukongviriyapan, V., Prawan, A., & Kukongviriyapan, U. (2014). Quercetin and EGCG Exhibit Chemopreventive Effects in Cholangiocarcinoma Cells via Suppression of JAK/STAT Signaling Pathway. Phytotherapy Research. https://doi.org/10.1002/ptr.5061
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