Induction of keratinocyte migration by ECa 233 is mediated through FAK/Akt, ERK, and p38 MAPK signaling
Abstract
Centella asiatica is widely considered the most important medicinal plant for treating and relieving skin diseases. Recently developed standardized extract of Centella asiatica ECa 233 has demonstrated positive effects on wound healing of incision and burn wound in rats. However, knowledge associated with wound healing mechanism of ECa 233 was scare. Therefore, this study aimed to investigate the effect and underlying molecular mechanisms of ECa 233 on the migration of a human keratinocyte cell line (HaCaT) using scratch wound healing assay. Formation of filopodia, a key protein in cell migration as well as signaling pathways possibly involved were subsequently assessed. It was found that HaCaT cell migration was significantly enhanced by ECa 233 in a concentration‐ and time‐dependent manner. The filopodia formations were accordingly increased in exposure to ECa 233 at concentrations of 0.1–100 μg/ml. Furthermore, ECa 233 was found to significantly upregulate the expression of Rac1 and RhoA and to induce phosphorylation of FAK and Akt as well as ERK and p38 MAPK. Taken all together, it is suggestive that ECa 233 induces cell migration and subsequently promotes wound healing activity, through the activation of FAK, Akt, and MAPK signaling pathways thereby supporting the role of ECa 233 to be further developed for the clinical treatment of wound.
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The observed wound-healing activity of ECa 233 occurs via activation of FAK, Akt and MAPK-dependent signalling pathways.
“The observed wound‐healing activity of ECa 233 occurs via the activation of FAK, Akt and MAPK‐dependant signalling pathways.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [94]
ECa 233 significantly enhanced keratinocyte migration in a concentration- and time-dependent manner in scratch wound-healing assay using HaCaT.
“Keratinocyte migration was significantly enhanced by ECa 233 in a concentration‐ and time‐dependent manner.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [94]
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- Authors
- Singkhorn, S., Tantisira, M. H., Tanasawet, S., Hutamekalin, P., Wongtawatchai, T., & Sukketsiri, W.
- Affiliations
- Prince of Songkla University (TH)
- Burapha University (TH)
- Corresponding author
- Sukketsiri, Wanida
- ORCID
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2018-03-13
- Volume
- 32
- Issue
- 7
- Pages
- 1397-1403
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2790368012
- Cited by
- 45
- References
- 34
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 1 · 2023: 7 · 2022: 5 · 2021: 12 · 2020: 9 · 2019: 2 · 2018: 1
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- General Project and Invention of Prince of Songkla University (SCI600421S)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
- Keywords
- Centella asiatica, keratinocyte migration, wound healing, HaCaT keratinocytes, filopodia formation, FAK/AKT signaling, ERK signaling, p38 MAPK signaling, Rac1, RhoA, medicinal plant extracts
- MeSH terms
- Animals, Cell Movement, Humans, Male, Plant Extracts, Plants, Medicinal, Keratinocytes, p38 Mitogen-Activated Protein Kinases, Proto-Oncogene Proteins c-akt, Rats
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