Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 434Piperaceae Chemical and Biological StudiesBerberine and alkaloids researchMedicinal Plant Research

The DOI matches its Crossref record; 172 of the 176 references it cites were found in a registry or an index.

Piperine: A review of its biological effects

Open access
Haq, Iahtisham‐Ul, Imran, Muhammad, Nadeem, Muhammad, Tufail, Tabussam, Gondal, Tanweer A., Mubarak, Mohammad S.·2021·Phytotherapy Research
DOI 10.1002/ptr.6855
Open this paper in CoChat — free account

Abstract

Medicinal plants have been used for years as a source of food, spices, and, in traditional medicine, as a remedy to numerous diseases.Piper nigrum, belonging to the family Piperaceae is one of the most widely used spices all over the world. It has a distinct sharp flavor attributed to the presence of the phytochemical, piperine. Apart from its use as a spice,P.nigrum is frequently used for medicinal, preservation, and perfumery purposes. Black pepper contains 2–7.4% of piperine, varying in content is associated with the pepper plant. Piperine displays numerous pharmacological effects such as antiproliferative, antitumor, antiangiogenesis, antioxidant, antidiabetic, anti‐obesity, cardioprotective, antimicrobial, antiaging, and immunomodulatory effects in various in vitro and in vivo experimental trials. Furthermore, piperine has also been documented for its hepatoprotective, anti‐allergic, anti‐inflammatory, and neuroprotective properties. This review highlights and discusses the medicinal and health‐promoting effects of piperine, along with possible mechanisms of its action in health promotion and disease prevention. In addition, the present review summarizes the recent literature related to piperine as a therapeutic agent against several diseases.

Overview

Integrity signals

Registry

Crossref · 10.1002/ptr.6855

Cites

172 of 172 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cited works that were retracted

Works this paper cites that were later retracted, from the retraction notices publishers deposit. Major when the notice came out before this paper was published.

1 of 1

Citations

Cites

1 retracted

Show all 176 references

Research works printed but not linked: 3

  1. Acharya S., 2012, Review of piperine as a bio‐enhancer, American Journal of PharmTech Research, 2, 32
  2. Alamgeer M. N. M., 2014, Evaluation of hypoglycemic activity of Thymus serpyllum Linn in glucose treated mice, International Journal of Basic Medical Sciences and Pharmacy (IJBMSP), 3, 33
  3. Joshi D. R., 2018, A review on diversified use of the king of spices: Piper nigrum (black pepper), International Journal of Pharmaceutical Sciences Research, 9, 4089

Cited by

See all 434

Related

See all

Metadata

Authors
Haq, I., Imran, M., Nadeem, M., Tufail, T., Gondal, T. A., & Mubarak, M. S.
Affiliations
  • Department of Diet and Nutritional Sciences, Faculty of Health and Allied Sciences Imperial College of Business Studies Lahore Pakistan
  • University of Lahore (PK)
  • COMSATS University Islamabad (PK)
  • Deakin University (AU)
  • University of Jordan (JO)
Corresponding author
Mubarak, Mohammad S.
ORCID
Venue
Phytotherapy Research
Publisher
Wiley
Published
2020-09-14
Volume
35
Issue
2
Pages
680-700
ISSN
  • 0951-418X (ISSN-L)
  • 1099-1573
DOI
10.1002/ptr.6855
OpenAlex
W3085908711
Semantic Scholar
f1aefe8820681c8820b0346e3ff0fd578de1476d
Cited by
434
References
176
Citations by year
2026: 72 · 2025: 97 · 2024: 100 · 2023: 92 · 2022: 40 · 2021: 28 · 2020: 1
FWCI
5.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Phytotherapy Research (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Piperaceae Chemical and Biological Studies
  • Health Sciences › Medicine › Pharmacology (medical) › Berberine and alkaloids research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
piperine, black pepper, spices, medicinal plants, antiproliferative activity, anticancer activity, angiogenesis inhibition, antioxidant activity, antidiabetic effect, anti-obesity, cardioprotection, antimicrobial activity, anti-aging, immunomodulation, hepatoprotection, anti-allergic effects, anti-inflammatory activity, neuroprotection, disease prevention
MeSH terms
Alkaloids, Animals, Drug Therapy, Combination, Humans, Piperidines, Benzodioxoles, Polyunsaturated Alkamides

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Piperine: A review of its biological effects. https://app.cochat.ai/papers/10.1002/ptr.6855
The paper
Haq, I., Imran, M., Nadeem, M., Tufail, T., Gondal, T. A., & Mubarak, M. S. (2021). Piperine: A review of its biological effects. Phytotherapy Research. https://doi.org/10.1002/ptr.6855

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.