Piperine: A review of its biological effects

Prevalence of Obesity Among Adults and Youth: United States, 2015-2016.

Hales, C. M., Carroll, M. D., Fryar, C. D., & Ogden, C. L. (2017) · PubMed · Cited by 3,884

Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers

Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P. (1998) · Planta Medica · doi:10.1055/s-2006-957450 · Cited by 1,656

Immunomodulatory and antitumor activity of Piper longum Linn. and piperine

Sunila, E. S., & Kuttan, G. (2003) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2003.10.016 · Cited by 539

Targeting breast stem cells with the cancer preventive compounds curcumin and piperine

Kakarala, M., Brenner, D. E., Korkaya, H., Cheng, C., Tazi, K., Ginestier, C., Liu, S., Dontu, G., & Wicha, M. S. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0612-x · Cited by 503

Fenaroli's Handbook of Flavor Ingredients

Burdock, G. A. (2001) · CRC Press eBooks · doi:10.1201/noe0849309465 · Cited by 490

Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis

Panahi, Y., Hosseini, M. S., Khalili, N., Naimi, E., Majeed, M. A., & Sahebkar, A. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2014.12.019 · Cited by 407

Biological role of Piper nigrum L. (Black pepper): A review

Ahmad, N., Fazal, H., Abbasi, B. H., Farooq, S., Ali, M., & Khan, M. A. (2012) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(12)60524-3 · Cited by 377

Piper nigrum and Piperine: An Update

Meghwal, M., & Goswami, T. K. (2013) · Phytotherapy Research · doi:10.1002/ptr.4972 · Cited by 366

Intranasal Piperine-Loaded Chitosan Nanoparticles as Brain-Targeted Therapy in Alzheimer's Disease: Optimization, Biological Efficacy, and Potential Toxicity

Elnaggar, Y. S. R., Etman, S. M., Abdelmonsif, D. A., & Abdallah, O. Y. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24557 · Cited by 327

Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials

Tripathi, A. K., Ray, A. K., & Mishra, S. K. (2022) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-022-00196-1 · Cited by 246

Moroccan medicinal plants traditionally used for the treatment of skin diseases: From ethnobotany to clinical trials

Ajjoun, M., Kharchoufa, L., Merrouni, I. A., & Elachouri, M. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115532 · Cited by 198

Curcumin‐piperine co‐supplementation and human health: A comprehensive review of preclinical and clinical studies

Heidari, H., Bagherniya, M., Majeed, M. A., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2023) · Phytotherapy Research · doi:10.1002/ptr.7737 · Cited by 195

Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications

Frolov, N. A., & Vereshchagin, A. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032937 · Cited by 192

Nanotechnology: A novel tool to enhance the bioavailability of micronutrients

Arshad, R., Gulshad, L., Ul‐Haq, I., Farooq, M. A., AL-Farga, A. M., Siddique, R., Manzoor, M. F., & Karrar, E. M. A. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2311 · Cited by 181

Plants Secondary Metabolites as Blood Glucose-Lowering Molecules

Shehadeh, M. B., Suaifan, G. A. R. Y., & Abu-Odeh, A. (2021) · Molecules · doi:10.3390/molecules26144333 · Cited by 147

Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022

Woo, S., Marquez, L., Crandall, W. J., Risener, C. J., & Quave, C. L. (2023) · Natural Product Reports · doi:10.1039/d2np00090c · Cited by 136

Recent Advancement in Chitosan-Based Nanoparticles for Improved Oral Bioavailability and Bioactivity of Phytochemicals: Challenges and Perspectives

Imam, S. S., Alshehri, S., Ghoneim, M. M., Zafar, A., Alsaidan, O. A., Alruwaili, N. K., Gilani, S. J., & Rizwanullah, M. (2021) · Polymers · doi:10.3390/polym13224036 · Cited by 121

Phytochemicals and Their Usefulness in the Maintenance of Health

Rodríguez-Negrete, E. V., Morales‐González, Á., Madrigal‐Santillán, E., Sánchez-Reyes, K., Álvarez‐González, I., Madrigal‐Bujaidar, E., Valadez-Vega, M. D. C., Chamorro, G., García-Melo, L. F., & Morales‐González, J. A. (2024) · Plants · doi:10.3390/plants13040523 · Cited by 116

Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

Qiu, C., Zhang, J. Z., Wu, B., Xu, C. C., Pang, H. H., Tu, Q., Lu, Y. Q., Guo, Q. Y., Xia, F., & Wang, J. G. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02165-x · Cited by 106

Evaluation of Antimicrobial Activity and Cytotoxicity Effects of Extracts of Piper nigrum L. and Piperine

Alves, F. S., Cruz, J. N., Ramos, I. N. D. F., Brandão, D. L. D. N., Queiroz, R. N., da Silva, G. V., da Silva, G. V., Dolabela, M. F., da Costa, M. L., Khayat, A. S., et al. (2022) · Separations · doi:10.3390/separations10010021 · Cited by 92

Computational screening of natural compounds as putative quorum sensing inhibitors targeting drug resistance bacteria: Molecular docking and molecular dynamics simulations

Chaieb, K., Kouidhi, B., Hosawi, S. B. I., Baothman, O. A. S., Zamzami, M. A., & Altayb, H. N. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.105517 · Cited by 87

Piperine promotes PI3K/AKT/mTOR-mediated gut-brain autophagy to degrade α-Synuclein in Parkinson’s disease rats

Yu, L., Hu, X., Xu, R., Zhao, Y., Xiong, L., Ai, J., Wang, X., Chen, X., Ba, Y., Xing, Z., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117628 · Cited by 80

Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

Antunes, J. C., Domingues, J., Miranda, C. S., Silva, A. F. G., Homem, N. C., de Amorim, M. T. P., & Felgueiras, H. P. (2021) · Marine Drugs · doi:10.3390/md19070359 · Cited by 79

Cancer chemoprevention: signaling pathways and strategic approaches

Ren, J., Yan, G., Yang, L., Kong, L., Guan, Y., Sun, H., Liu, C., Liu, L., Han, Y., & Wang, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02167-1 · Cited by 75

Sulforaphane as a potential remedy against cancer: Comprehensive mechanistic review

Ul‐Haq, I., Khan, S., Awan, K. A., & Iqbal, M. J. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13886 · Cited by 73

Neuroprotective Effects of Black Pepper and Its Bioactive Compounds in Age-Related Neurological Disorders

Balakrishnan, R., Azam, S., Kim, I., & Choi, D. (2022) · Aging and Disease · doi:10.14336/ad.2022.1022 · Cited by 72

Piperine and Its Metabolite’s Pharmacology in Neurodegenerative and Neurological Diseases

Azam, S., Park, J., Kim, I., & Choi, D. (2022) · Biomedicines · doi:10.3390/biomedicines10010154 · Cited by 64

Synergistic Antibiofilm Efficacy of Thymol and Piperine in Combination with Three Aminoglycoside Antibiotics against Klebsiella pneumoniae Biofilms

Bisso, B. N., Kuaté, C. R. T., & Dzoyem, J. P. (2021) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2021/7029944 · Cited by 62

Pharmacologic Activities of Plant‐Derived Natural Products on Respiratory Diseases and Inflammations

Timalsina, D., Pokhrel, K. P., & Bhusal, D. (2021) · BioMed Research International · doi:10.1155/2021/1636816 · Cited by 61

Bioactive Properties, Bioavailability Profiles, and Clinical Evidence of the Potential Benefits of Black Pepper (Piper nigrum) and Red Pepper (Capsicum annum) against Diverse Metabolic Complications

Dludla, P. V., Cirilli, I., Marcheggiani, F., Silvestri, S., Orlando, P., Muvhulawa, N., Moetlediwa, M. T., Nkambule, B. B., Mazibuko-Mbeje, S. E., Hlengwa, N., et al. (2023) · Molecules · doi:10.3390/molecules28186569 · Cited by 60

Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl 4 : roles in the activation of the Nrf2 cascade and subsequent suppression of the TGF-β1/Smad axis

Shu, G., Yusuf, A., Dai, C., Sun, H. M., & Deng, X. (2021) · Food & Function · doi:10.1039/d1fo02657g · Cited by 58

Anti-diarrheal effect of piperine possibly through the interaction with inflammation inducing enzymes: In vivo and in silico studies

Afroz, M., Bhuia, M. S., Rahman, M. A., Hasan, R., Islam, T., Islam, M. R., Chowdhury, R., Khan, M. A., Silva, D. A. E., Coutinho, H. D. M., et al. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176289 · Cited by 57

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

Rahat, I., Yadav, P., Singhal, A., Fareed, M., Purushothaman, J., Aslam, M., Balaji, R., Shinde, S., & Rizwanullah, M. (2024) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.15.118 · Cited by 57

Targeting the Nrf2 signaling pathway using phytochemical ingredients: A novel therapeutic road map to combat neurodegenerative diseases

Bai, X., Bian, Z., & Zhang, M. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154582 · Cited by 54

Alkaloids unveiled: A comprehensive analysis of novel therapeutic properties, mechanisms, and plant-based innovations

Sarvananda, L., Madhuranga, H. D. T., Madhurangi, B. L. N. K., Premarathna, A. D., & Saravanan, M. (2024) · Intelligent Pharmacy · doi:10.1016/j.ipha.2024.09.007 · Cited by 53

Safety Aspects of the Use of Isolated Piperine Ingested as a Bolus

Ziegenhagen, R., Heimberg, K., Lampen, A., & Hirsch‐Ernst, K. I. (2021) · Foods · doi:10.3390/foods10092121 · Cited by 52

Synergistic Antibiofilm Effect of Thymol and Piperine in Combination with Aminoglycosides Antibiotics against Four Salmonella enterica Serovars

Kuaté, C. R. T., Bisso, B. N., & Dzoyem, J. P. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/1567017 · Cited by 51

Piperine ameliorates ischemic stroke-induced brain injury in rats by regulating the PI3K/AKT/mTOR pathway

Zhang, Y., Yang, M., Yuan, Q., He, Q., Ping, H., Yang, J., Zhang, Y., Fu, X., & Liu, J. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115309 · Cited by 50

Natural products in attenuating renal inflammation via inhibiting the NLRP3 inflammasome in diabetic kidney disease

Wang, Y., Sui, Z., Wang, M., & Liu, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1196016 · Cited by 49

Integrating phytochemicals and in silico methods for modern drug discovery: a comprehensive review

Babalola, O. O., Bridget, K., Oyubu, G., Adio, W. S., Ajiboye, S. A., Fakayode, A. E., Edema, A. A., Udensi, C. G., Tiamiyu, R. T., Fakayode, A. J., et al. (2025) · Discover Chemistry. · doi:10.1007/s44371-025-00373-y · Cited by 49

Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results

Arifian, H., Maharani, R., Megantara, S., Gazzali, A. M., & Muchtaridi, M. (2022) · Molecules · doi:10.3390/molecules27217631 · Cited by 46

Piperine: an emerging biofactor with anticancer efficacy and therapeutic potential

Wiraswati, H. L., Ma’ruf, I. F., Sharifi‐Rad, J., & Călina, D. C. (2024) · BioFactors · doi:10.1002/biof.2134 · Cited by 46

Advanced sample preparation and chromatographic techniques for analyzing plant-based bioactive chemicals in nutraceuticals

HÜRKUL, M. M., Çetinkaya, A., Yayla, Ş., & Özkan, S. A. (2024) · Journal of Chromatography Open · doi:10.1016/j.jcoa.2024.100131 · Cited by 45

The Involvement of Antioxidants in Cognitive Decline and Neurodegeneration: Mens Sana in Corpore Sano

Nazzi, C., Avenanti, A., & Battaglia, S. (2024) · Antioxidants · doi:10.3390/antiox13060701 · Cited by 44

The Hepatoprotective Effect of Piperine Against Thioacetamide-Induced Liver Fibrosis in Mice: The Involvement of miR-17 and TGF-β/Smads Pathways

Abdelhamid, A. M., Selim, A., & Zaafan, M. A. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.754098 · Cited by 44

I Am the 1 in 10—What Should I Eat? A Research Review of Nutrition in Endometriosis

Piecuch, M., Garbicz, J., Waliczek, M., Malinowska-Borowska, J., & Rozentryt, P. (2022) · Nutrients · doi:10.3390/nu14245283 · Cited by 43

Piperine modulates IR/Akt/GLUT4 pathways to mitigate insulin resistance: Evidence from animal and computational studies

Prasad, M., Jayaraman, S., Natarajan, S. R., Veeraraghavan, V. P., Krishnamoorthy, R., Gatasheh, M. K., Palanisamy, C. P., & Elrobh, M. S. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127242 · Cited by 41

The king of spices: On pepper's pungent pleasure

Spence, C. J. (2024) · International Journal of Gastronomy and Food Science · doi:10.1016/j.ijgfs.2024.100900 · Cited by 41

Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer

He, M., Xia, L., & Li, J. (2021) · Biomolecules · doi:10.3390/biom11101539 · Cited by 41

Natural inspired piperine-based ureas and amides as novel antitumor agents towards breast cancer

Elimam, D. M., Elgazar, A. A., El‐Senduny, F. F., El-Domany, R. A., Badria, F. A.-E., & Eldehna, W. M. (2021) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2021.1988944 · Cited by 41

High-throughput wastewater analysis for substance use assessment in central New York during the COVID-19 pandemic

Wang, S., Green, H., Wilder, M. L., Du, Q., Kmush, B. L., Collins, M. B., Larsen, D. A., & Zeng, T. (2020) · Environmental Science Processes & Impacts · doi:10.1039/d0em00377h · Cited by 40

Conjugation, Prodrug, and Co-Administration Strategies in Support of Nanotechnologies to Improve the Therapeutic Efficacy of Phytochemicals in the Central Nervous System

Rassu, G., Sorrenti, M., Catenacci, L., Pavan, B., Ferraro, L., Gavini, E., Bonferoni, M. C., Giunchedi, P., & Dalpiaz, A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061578 · Cited by 39

A review on integrative approaches in oncology: bridging ayurvedic medicine and modern cancer therapeutics

Jha, S. K., Singh, N., Shanker, O. R., Antil, I., Baghel, J. S., Huddar, V. G., & Tripathi, R. (2025) · Frontiers in Natural Products · doi:10.3389/fntpr.2025.1635197 · Cited by 39

Inhibition of AdeB, AceI, and AmvA Efflux Pumps Restores Chlorhexidine and Benzalkonium Susceptibility in Acinetobacter baumannii ATCC 19606

Migliaccio, A., Esposito, E. P., Bagattini, M., Berisio, R., Triassi, M., Gregorio, E. D., & Zarrilli, R. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.790263 · Cited by 39

Effect of Piperine on Saltiness Perception

Moss, R. H., Fisher, C., Gorman, M., Knowles, S., LeBlanc, J., Ritchie, C., Schindell, K., Ettinger, L., & McSweeney, M. B. (2023) · Foods · doi:10.3390/foods12020296 · Cited by 38

Piperine Improves Hyperuricemic Nephropathy by Inhibiting URAT1/GLUT9 and the AKT-mTOR Pathway

Li, L., Zhao, K., Luo, J. F., Tian, J., Zheng, F., Lin, X., Xie, Z., Jiang, H., Li, Y., Zhao, Z., et al. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c07655 · Cited by 35

TLC-Based Metabolite Profiling and Bioactivity-Based Scientific Validation for Use of Water Extracts in AYUSH Formulations

Zahiruddin, S., Parveen, A., Khan, W., Parveen, R., & Ahmad, S. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/2847440 · Cited by 35

Piperine loaded drug delivery systems for improved biomedical applications: Current status and future directions

Arora, S., Singh, B., Kumar, S., Kumar, A., Singh, A., & Singh, C. (2023) · Health Sciences Review · doi:10.1016/j.hsr.2023.100138 · Cited by 34

The Synergism of Natural Compounds and Conventional Therapeutics against Colorectal Cancer Progression and Metastasis

Liang, Z., Xie, H., Shen, W., Le, S., Zeng, L., Huang, X., Zhu, Q., Zhai, X., Li, K., Qiu, Z., et al. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2709263 · Cited by 34

Chemical Characterisation, Antidiabetic, Antibacterial, and In Silico Studies for Different Extracts of Haloxylon stocksii (Boiss.) Benth: A Promising Halophyte

Rizvi, S. N. R., Afzal, S., Khan, K.-U.-R., Aati, H. Y., Rao, H., Ghalloo, B. A., Shahzad, M. N., Khan, D. A., Esatbeyoglu, T., & Korma, S. A. (2023) · Molecules · doi:10.3390/molecules28093847 · Cited by 34

Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer

Ramos, I. N. D. F., da Silva, M. F., Lopes, J. M. S., Cruz, J. N., Alves, F. S., do Rêgo, J. D. A. R., da Costa, M. L., de Assumpção, P. P., Brasil, D. D. S. B., & Khayat, A. S. (2023) · Molecules · doi:10.3390/molecules28145587 · Cited by 34

Synthesis of 1-Piperoylpiperidine Investigated Through Spectroscopy, Quantum Computation, Pharmaceutical Activity, Docking and MD Simulation Against Breast Cancer

Chandran, K., Zochedh, A., Bahadur, S. A., & Kathiresan, T. (2023) · Polycyclic aromatic compounds · doi:10.1080/10406638.2023.2239985 · Cited by 33

A Standardized Withania somnifera (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study

Majeed, M. A., Nagabhushanam, K., Murali, A., Vishwanathan, D. T., Mamidala, R. V., & Mundkur, L. (2023) · Journal of Integrative and Complementary Medicine · doi:10.1089/jicm.2023.0279 · Cited by 33

Formulation of Piperine Nanoparticles: In Vitro Breast Cancer Cell Line and In Vivo Evaluation

Kazmi, I. A., Al-Abbasi, F. A., Imam, S. S., Afzal, M., Nadeem, M. S., Altayb, H. N., & Alshehri, S. (2022) · Polymers · doi:10.3390/polym14071349 · Cited by 33

Piperine is capable of improving pancreatic β-cell apoptosis in high fat diet and streptozotocin induced diabetic mice

Qian, H., Xu, J., Gu, J. L., Tong, X., Wan, Z., Gu, Y., Fang, C., & Qin, L. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104890 · Cited by 30

Piperine Provides Neuroprotection against Kainic Acid-Induced Neurotoxicity via Maintaining NGF Signalling Pathway

Hsieh, T.-Y., Chang, Y., & Wang, S. (2022) · Molecules · doi:10.3390/molecules27092638 · Cited by 30

Piperine attenuates production of inflammatory biomarkers, oxidative stress and neutrophils in lungs of cigarette smoke-exposed experimental mice

Arora, P., Athari, S. S., & Nainwal, L. M. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101909 · Cited by 30

Piperine attenuates the inflammation, oxidative stress, and pyroptosis to facilitate recovery from spinal cord injury via autophagy enhancement

Zhang, H., Wu, C., Yu, D., Su, H., Chen, Y., & Ni, W. (2022) · Phytotherapy Research · doi:10.1002/ptr.7625 · Cited by 30

Hot-Melt Extrusion as an Effective Technique for Obtaining an Amorphous System of Curcumin and Piperine with Improved Properties Essential for Their Better Biological Activities

Wdowiak, K., Pietrzak, R., Tykarska, E., & Cielecka‐Piontek, J. (2023) · Molecules · doi:10.3390/molecules28093848 · Cited by 30

Piperine as Therapeutic Agent in Paracetamol-Induced Hepatotoxicity in Mice

Coelho, A. M., Queiroz, I. F., Perucci, L. O., de Souza, M. O., de Lima, W. G., Talvani, A., & Costa, D. C. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091800 · Cited by 29

Development of Novel Piperine‐Loaded Mesoporous Silica Nanoparticles: Enhanced Drug Delivery and Comprehensive In Vivo Safety Analysis

Francis, R., Parthasarathy, S., Aly, S. H., Kalyanaraman, R., Boominathan, V., Tharumasivam, S. V., El‐Shazly, M., Murugan, B. M., & Gnanadesigan, M. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202401901 · Cited by 28

Therapeutic Potential of Plant- and Marine-Derived Bioactive Compounds in Prostate Cancer: Mechanistic Insights and Translational Applications

Siddiqui, A. J., Adnan, M., Saxena, J., Alam, M. J., Abdelgadir, A., Badraoui, R., & Singh, R. (2025) · Pharmaceuticals · doi:10.3390/ph18030286 · Cited by 28

RECENT STRATEGIES FOR IMPROVING SOLUBILITY AND ORAL BIOAVAILABILITY OF PIPERINE

Salsabila, H., Fitriani, L., & Zaini, E. (2021) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2021v13i4.41596 · Cited by 28

Modern aspects of the use of natural polyphenols in tumor prevention and therapy

Суфианова, Г. З., Фанилевич, Г. И., Beylerli, O., Wu, J., Shumadalova, A. V., Sufianov, A. A., Chen, X., & Zhao, S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1011435 · Cited by 28

Amelioration of cyclophosphamide-induced DNA damage, oxidative stress, and hepato- and neurotoxicity by Piper longum extract in rats: The role of γH2AX and 8-OHdG

Yadav, V., Krishnan, A., Zahiruddin, S., Ahmad, S., & Vohora, D. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1147823 · Cited by 28

Exploiting natural products to discover multitarget inhibitors of insect chitinolytic enzymes

Ding, Y., Lu, Q., Liu, T., & Yang, Q. K. (2023) · Advanced Agrochem · doi:10.1016/j.aac.2023.07.007 · Cited by 28

Computational profiling of anti-inflammatory phytochemicals targeting 5-LOX and COX-2 pathways: PASS prediction, molecular docking and ADMET analysis

Parvin, M. S., Shakib, M. S. I., Hossain, M. S., Sinthi, A. T., & Islam, M. E. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111604 · Cited by 27

Alkaloids: The Potential of Their Antimicrobial Activities of Medicinal Plants

Barati, M., & Chahardehi, A. M. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.112364 · Cited by 27

Quality by design‐based development and validation of an HPLC method for simultaneous estimation of pregabalin and piperine in dual drug‐loaded liposomes

Gupta, I., Adin, S. N., Aqil, M., Mujeeb, M., & Sultana, Y. (2022) · Biomedical Chromatography · doi:10.1002/bmc.5510 · Cited by 26

Multistage Extraction of Star Anise and Black Pepper Derivatives for Antibacterial, Antioxidant, and Anticancer Activity

Li, H., Wu, X., Li, X., Cao, X., Li, Y., Cao, H., & Men, Y. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.660138 · Cited by 26

Piperine alleviates acute pancreatitis: A possible role for FAM134B and CCPG1 dependent ER-phagy

Huang, W., Zhang, J., Jin, W., Yang, J., Yu, G., Shi, H., & Shi, K. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154361 · Cited by 25

Ethosomes for Curcumin and Piperine Cutaneous Delivery to Prevent Environmental-Stressor-Induced Skin Damage

Ferrara, F., Bondi, A., Pula, W., Contado, C., Baldisserotto, A., Manfredini, S., Boldrini, P., Sguizzato, M., Montesi, L., Benedusi, M., et al. (2024) · Antioxidants · doi:10.3390/antiox13010091 · Cited by 25

Metabolic Insights into Drug Absorption: Unveiling Piperine's Transformative Bioenhancing Potential

Tripathi, D., Gupta, V. K., Pandey, P. K., & Rajinikanth, P. S. (2025) · Pharmaceutical Research · doi:10.1007/s11095-025-03920-5 · Cited by 24

Piperine ameliorates psoriatic skin inflammation by inhibiting the phosphorylation of STAT3

Lu, H. J., Gong, H., Du, J., Gao, W., Xu, J. F., Cai, X., Yang, Y., & Xiao, H. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110221 · Cited by 24

Comparative metabolite analysis of Piper sarmentosum organs approached by LC–MS-based metabolic profiling

Ware, I., Franke, K., Frolov, A., Bureiko, K., Kysil, E. V., Yahayu, M., Enshasy, H. A. E., & Wessjohann, L. A. (2024) · Natural Products and Bioprospecting · doi:10.1007/s13659-024-00453-z · Cited by 24

An Overview of Food Bioactive Compounds and Their Health-Promoting Features

Kamiloğlu, S., Çapanoğlu, E., & Jafari, S. M. (2022) · Food bioactive ingredients · doi:10.1007/978-3-030-96885-4_1 · Cited by 23

Piperine, quercetin, and curcumin identified as promising natural products for topical treatment of cutaneous leishmaniasis

Clemente, C. M., Murillo, J. D., Garro, A. G., Arbeláez, N., Pineda, T., Robledo, S. M., & Ravetti, S. (2024) · Parasitology Research · doi:10.1007/s00436-024-08199-w · Cited by 23

Piperine induces autophagy of colon cancer cells: Dual modulation of AKT/mTOR signaling pathway and ROS production

Xia, J., Guo, P., Yang, H. J., Zhang, T., Pan, K., & Wei, H. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150340 · Cited by 23

Effects and mechanisms of natural alkaloids for prevention and treatment of osteoporosis

Lin, B., Xu, P., Zheng, J., Deng, X., Ye, Q., Huang, Z., & Wang, N. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1014173 · Cited by 23

Plant-derived natural compounds for the treatment of acute lung injury: A systematic review of their anti-inflammatory effects in animal models

Chen, X., Wang, W., Zhang, H., Liang, N., Chen, D., Li, J., Ding, W., He, Z., Yuan, Y., Chu, C., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113807 · Cited by 22

“Pepper”: Different Spices, One Name—Analysis of Sensory and Biological Aspects

Díaz-Guerrero, P., Panzani, S., Sanmartin, C., Muntoni, C., Taglieri, I., & Venturi, F. (2025) · Molecules · doi:10.3390/molecules30091891 · Cited by 22

Piperine Improves DSS ‐Induced Colitis in Mice via Inhibition of Inflammation and Modulation of Gut Microbiota

Hu, Y., Wang, Y., Gao, H., Yang, G., Xie, J., He, Z., Lv, S., Gu, F., Huang, C., & Hu, W. (2025) · Phytotherapy Research · doi:10.1002/ptr.8491 · Cited by 22

Target identification of natural products in cancer with chemical proteomics and artificial intelligence approaches

Li, G., Shi, Q., Wu, Q., & Sui, X. (2025) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2025.0145 · Cited by 22

Piperine loaded metal organic frameworks reverse doxorubicin induced chemobrain in adult zebrafish

Arora, S., Kumar, V., Kapil, L., Agrawal, A. K., Singh, A., & Singh, C. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.077 · Cited by 22

Piperine-Loaded Glycyrrhizic Acid- and PLGA-Based Nanoparticles Modified with Transferrin for Antitumor

Li, S., Guo, J., Tian, Z., Chen, J., Gou, G., Niu, Y., Li, L., & Yang, J. (2021) · AAPS PharmSciTech · doi:10.1208/s12249-021-02123-6 · Cited by 21

Targeting NF-κB in diabetic nephropathy: exploring the therapeutic potential of phytoconstituents

Abhirami, B. L., Krishna, A. A., Kumaran, A., & Chiu, C. (2025) · Archives of Pharmacal Research · doi:10.1007/s12272-025-01555-z · Cited by 20

Natural Alkaloids as Antimicrobial Agents: Mechanisms, Potentials and Challenges

Zhang, X.-Z., Chen, M., Hou, R., Wang, W., He, Z.-D., You, J., & Song, X. (2026) · Molecules · doi:10.3390/molecules31071204 · Cited by 20

Zebrafish as a tool for the discovery of anticonvulsant compounds from botanical constituents

Bertoncello, K. T., & Bonan, C. D. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174342 · Cited by 20

A minor metabolite from Curcuma longa effective against metabolic syndrome: results from a randomized, double-blind, placebo-controlled clinical study

Majeed, M. A., Nagabhushanam, K., Devarajan, T. V., Saklecha, S., Reddy, S. V. K., & Mundkur, L. (2023) · Food & Function · doi:10.1039/d2fo03627d · Cited by 20

Development of Piperine-Loaded Soft Binary Ethosomal Gel to Improve Transdermal Delivery: Box-Bhekhen Design Optimization, Ex-Vivo Permeation, and Antimicrobial Evaluation

Zafar, A., Yasir, M., & Khalid, M. (2023) · Journal of Cluster Science · doi:10.1007/s10876-023-02479-8 · Cited by 20

Anti-tyrosinase and anti-melanogenic effects of piperine isolated from Piper nigrum on B16F10 mouse melanoma cells

Khongkarat, P., Sadangrit, P., Puthong, S., Meemongkolkiat, T., Phuwapraisirisan, P., & Chanchao, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33423 · Cited by 20

Bagging the role of herbal drugs in the management of cervical cancer

Mehta, V., Zargar, A. A., Attri, P., & Jha, S. K. (2025) · Ayush journal of integrative oncology. · doi:10.4103/ajio.ajio_4_25 · Cited by 20

Black pepper prevents anemia of inflammation by inhibiting hepcidin over-expression through BMP6-SMAD1/ IL6-STAT3 signaling pathway

Banerjee, S., Katiyar, P., Kumar, L., Kumar, V., Saini, S. S., Krishnan, V., Sircar, D., & Roy, P. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.019 · Cited by 20

Piperine supplementation in diet improves growth, feed efficiency, innate immunity, digestibility and disease resistance of Pacific white shrimp (Litopenaeus vannamei)

Shin, J., Yun, K.-S., Gunathilaka, B. E., Hasanthi, M., Ko, D., Lim, H., Lim, J., Eom, G., Kim, H.-S., & Lee, K. (2023) · Aquaculture Reports · doi:10.1016/j.aqrep.2023.101490 · Cited by 20

Green synthesis of Piper chaudocanum stem extract mediated silver nanoparticles for colorimetric detection of Hg 2+ ions and antibacterial activity

Tâm, K. T., Thủy, N. T., Ngan, N. T. K., Khải, N. M., & Thành, Đ. V. (2023) · Royal Society Open Science · doi:10.1098/rsos.220819 · Cited by 19

Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function

Alkanad, M. A., Hani, U., Annegowda, H. V., Ghazwani, M., Haider, N., Osmani, R. A. M., Pandareesh, M. D., Hamsalakshmi, & Bhat, R. (2024) · BioFactors · doi:10.1002/biof.2034 · Cited by 19

Use of Herbal Medicines Among Breastfeeding Mothers in Tanzania: A Cross-Sectional Study

Millinga, V., Im, H. B., Hwang, J. H., Choi, S. J., & Han, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.751129 · Cited by 18

Effect of extraction technique on chemical compositions and antioxidant activities of freeze-dried green pepper

Zhang, C., Gu, F., Hu, W., Wu, G., Chen, W., Dong, C., & Niu, Z. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.998840 · Cited by 18

Synergistic Effect of Piperine and its Derivatives: A Comprehensive Review

Chopra, B., Saini, N., & Dhingra, A. K. (2022) · Current Drug Research Reviews · doi:10.2174/2589977515666221101153730 · Cited by 18

A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices

Damanhouri, Z. A. (2014) · Medicinal & Aromatic Plants · doi:10.4172/2167-0412.1000161 · Cited by 257

Black Pepper (Piper nigrum L.): The King of Spices

Soni, P., Soni, V., & Choudhary, N. K. (2020) · Science of spices & herbs · doi:10.2174/9789811468360120030008 · Cited by 1

Therapeutic Role of Piper nigrum L (Black Pepper) and Pharmacological Activities

Saleem, A., Naureen, I., Naeem, M., Tasleem, G., Ahmed, H., & Farooq, U. (2022) · Scholars International Journal of Biochemistry · doi:10.36348/sijb.2022.v05i01.003 · Cited by 41

Therapeutic Potential of Piperine: A Review

Sarkar, S., Sarkar, S., Sanjib, G., Mistry, J., & Biswas, M. (2023) · International Journal of Zoological Investigations · doi:10.33745/ijzi.2023.v09i02.020

Therapeutic Potential of Piperine: A Comprehensive Review

Singh, S. K., & Shukla, A. (2023) · The Natural Products Journal · doi:10.2174/0122103155273860230928071249 · Cited by 6