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Cited by 608

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Functional balance between haemagglutinin and neuraminidase in influenza virus infections

Wagner, Ralf, Matrosovich, Mikhail, Klenk, Hans‐Dieter·2002·Reviews in Medical Virology
DOI 10.1002/rmv.352
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Abstract

Influenza A and B viruses carry two surface glycoproteins, the haemagglutinin (HA) and the neuraminidase (NA). Both proteins have been found to recognise the same host cell molecule, sialic acid. HA binds to sialic acid‐containing receptors on target cells to initiate virus infection, whereas NA cleaves sialic acids from cellular receptors and extracellular inhibitors to facilitate progeny virus release and to promote the spread of the infection to neighbouring cells. Numerous studies performed recently have revealed that an optimal interplay between these receptor‐binding and receptor‐destroying activities of the surface glycoproteins is required for efficient virus replication. An existing balance between the antagonistic HA and NA functions of individual viruses can be disturbed by various events, such as reassortment, virus transmission to a new host, or therapeutic inhibition of neuraminidase. The resulting decrease in the viral replicative fitness is usually overcome by restoration of the functional balance due to compensatory mutations in HA, NA or both proteins. Copyright © 2002 John Wiley & Sons, Ltd.

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Metadata

Authors
Wagner, R., Matrosovich, M., & Klenk, H.
Venue
Reviews in Medical Virology
Publisher
Wiley
Published
2002-04-25
Volume
12
Issue
3
Pages
159-166
ISSN
  • 1052-9276 (ISSN-L)
  • 1099-1654
DOI
10.1002/rmv.352
OpenAlex
W2107651145
Cited by
608
References
44
FWCI
6.65
Type
journal article
Language
en
Open access
closed

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