The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development
Open accessAbstract
Tumors are composed of different types of cancer cells that contribute to tumor heterogeneity. Among these populations of cells, cancer stem cells (CSCs) play an important role in cancer initiation and progression. Like their stem cells counterpart, CSCs are also characterized by self-renewal and the capacity to differentiate. A particular population of CSCs is constituted by mesenchymal stem cells (MSCs) that differentiate into cells of mesodermal characteristics. Several studies have reported the potential pro-or anti-tumorigenic influence of MSCs on tumor initiation and progression. In fact, MSCs are recruited to the site of wound healing to repair damaged tissues, an event that is also associated with tumorigenesis. In other cases, resident or migrating MSCs can favor tumor angiogenesis and increase tumor aggressiveness. This interplay between MSCs and cancer cells is fundamental for cancerogenesis, progression, and metastasis. Therefore, an interesting topic is the relationship between cancer cells, CSCs, and MSCs, since contrasting reports about their respective influences have been reported. In this review, we discuss recent findings related to conflicting results on the influence of normal and CSCs in cancer development. The understanding of the role of MSCs in cancer is also important in cancer management.
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1 retracted
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Stem cells, cancer, and cancer stem cells
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Cited by
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
Galon, J., & Bruni, D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0007-y · Cited by 3,409
Exosomes in Angiogenesis and Anti-angiogenic Therapy in Cancers
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Galland, S., & Stamenkovic, I. (2020) · The Journal of Pathology · doi:10.1002/path.5357 · Cited by 165
Zheng, Y., Wang, G., Chen, R., Hua, Y., & Cai, Z. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0780-x · Cited by 127
Role of MSC in the Tumor Microenvironment
Hass, R. (2020) · Cancers · doi:10.3390/cancers12082107 · Cited by 116
Metadata
- Authors
- Papaccio, F., Paino, F., Regad, T., Papaccio, G., Desiderio, V., & Tirino, V.
- Venue
- Stem Cells Translational Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-10-26
- Volume
- 6
- Issue
- 12
- Pages
- 2115-2125
- ISSN
- 2157-6564 (ISSN-L)
- 2157-6580
- OpenAlex
- W2767025366
- Cited by
- 292
- References
- 105
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development. https://app.cochat.ai/papers/10.1002/sctm.17-0138
- The paper
- Papaccio, F., Paino, F., Regad, T., Papaccio, G., Desiderio, V., & Tirino, V. (2017). Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development. Stem Cells Translational Medicine. https://doi.org/10.1002/sctm.17-0138
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
