Randomization by minimization for unbalanced treatment allocation

Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial

Pocock, S. J., & Simon, R. (1975) · Biometrics · doi:10.2307/2529712 · Cited by 2,350 · see citing works

Minimization: A new method of assigning patients to treatment and control groups

Taves, D. R. (1974) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1974155443 · Cited by 891 · see citing works

Stratified Randomization for Clinical Trials

Kernan, W. N., Viscoli, C. M., Makuch, R. W., Brass, L. M., & Horwitz, R. I. (1999) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00138-3 · Cited by 627 · see citing works

Treatment with the gonadotrophin-releasing hormone antagonist ganirelix in women undergoing ovarian stimulation with recombinant follicle stimulating hormone is effective, safe and convenient: results of a controlled, randomized, multicentre trial

The European Orgalutran® Study Group, Borm, G. F., & Mannaerts, B. M. J. L. (2000) · Human Reproduction · doi:10.1093/humrep/15.7.1490 · Cited by 377 · see citing works

The use of unequal randomisation ratios in clinical trials: A review

Dumville, J. C., Hahn, S., Miles, J. N. V., & Torgerson, D. J. (2005) · Contemporary Clinical Trials · doi:10.1016/j.cct.2005.08.003 · Cited by 316 · see citing works

The Pursuit of Balance Using Stratified and Dynamic Randomization Techniques: An Overview

McEntegart, D. J. (2003) · Drug Information Journal · doi:10.1177/009286150303700305 · Cited by 145 · see citing works

How many controls?

Gail, M. H., Williams, R., Byar, D. P., & Brown, C. (1976) · Journal of Chronic Diseases · doi:10.1016/0021-9681(76)90073-4 · Cited by 137 · see citing works

Statistical comparison of random allocation methods in cancer clinical trials

Hagino, A., Hamada, C., Yoshimura, I., Ohashi, Y., Sakamoto, J., & Nakazato, H. (2004) · Controlled Clinical Trials · doi:10.1016/j.cct.2004.08.004 · Cited by 51 · see citing works

Optimum Sample Sizes for the Comparison of the Control and Treatment

Nam, J. (1973) · Biometrics · doi:10.2307/2529679 · Cited by 39 · see citing works

Efficient Allocation of Patients to Treatment Cells in Clinical Trials With More Than Two Treatment Conditions

Woods, S. W., Sholomskas, D. E., Shear, M. K., Gorman, J. M., Barlow, D. H., Goddard, A. W., & Cohen, J. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.10.1446 · Cited by 23 · see citing works

Letter to the Editor re Dumville et al. Contemp. Clin. Trials 2006;27:1–12

McEntegart, D. J., & Dawson, R. (2006) · Contemporary Clinical Trials · doi:10.1016/j.cct.2006.02.003 · Cited by 10 · see citing works

Dynamic Treatment Allocation Adjusting for Prognostic Factors for More Than Two Treatments

Dror, S., Faraggi, D., & Reiser, B. (1995) · Biometrics · doi:10.2307/2533264 · Cited by 5 · see citing works

SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials

Chan, A.-W., Tetzlaff, J. M., Gotzsche, P. C., Altman, D. G., Mann, H., Berlin, J. A., Dickersin, K., Hrobjartsson, A., Schulz, K. F., Parulekar, W. R., et al. (2013) · BMJ · doi:10.1136/bmj.e7586 · Cited by 6,251 · see citing works

A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma

Brandes, A. A., Carpentier, A. F., Kesari, S., Sepulveda-Sanchez, J. M., Wheeler, H. R., Chinot, O., Cher, L., Steinbach, J. P., Capper, D., Specenier, P., et al. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now009 · Cited by 273 · see citing works

Allocation techniques for balance at baseline in cluster randomized trials: a methodological review

Ivers, N. M., Halperin, I. J., Barnsley, J. M., Grimshaw, J., Shah, B. R., Tu, K., Upshur, R. E. G., & Zwarenstein, M. (2012) · Trials · doi:10.1186/1745-6215-13-120 · Cited by 251 · see citing works

Implementation of an open-source customizable minimization program for allocation of patients to parallel groups in clinical trials

Saghaei, M., & Saghaei, S. (2011) · Journal of Biomedical Science and Engineering · doi:10.4236/jbise.2011.411090 · Cited by 239 · see citing works

SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials

Hróbjartsson, A., Boutron, I., Hopewell, S., Moher, D., Schulz, K. F., Collins, G. S., Tunn, R., Aggarwal, R., Berkwits, M., Berlin, J. A., et al. (2025) · BMJ · doi:10.1136/bmj-2024-081660 · Cited by 171 · see citing works

Maintenance therapy with bacillus Calmette‐Guérin Connaught strain clearly prolongs recurrence‐free survival following transurethral resection of bladder tumour for non‐muscle‐invasive bladder cancer

Hinotsu, S., Akaza, H., Naito, S., Ozono, S., Sumiyoshi, Y., Noguchi, S., Yamaguchi, A., Nagamori, S., Terai, A., Nasu, Y., et al. (2010) · British Journal of Urology · doi:10.1111/j.1464-410x.2010.09891.x · Cited by 100 · see citing works

Azithromycin for Early Pseudomonas Infection in Cystic Fibrosis. The OPTIMIZE Randomized Trial

Mayer-Hamblett, N., Retsch‐Bogart, G. Z., Kloster, M., Accurso, F. J., Rosenfeld, M., Albers, G. M., Black, P., Brown, P. S., Cairns, A., Davis, S. D., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201802-0215oc · Cited by 99 · see citing works

TGFβ receptor inhibitor galunisertib is linked to inflammation- and remodeling-related proteins in patients with pancreatic cancer

Melisi, D., García‐Carbonero, R., Macarulla, T. M., Pezet, D., Deplanque, G., Fuchs, M., Trojan, J., Kozloff, M. F., Simionato, F., Cleverly, A., et al. (2019) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-019-03807-4 · Cited by 92 · see citing works

The effect of daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, and function in healthy older adults: A randomized controlled trial

Mertz, K. H., Reitelseder, S., Bechshoeft, R. L., Bülow, J., Højfeldt, G. W., Jensen, M., Schacht, S. R., Lind, M. V., Rasmussen, M. A., Mikkelsen, U. R., et al. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa372 · Cited by 91 · see citing works

Does EEG ‐neurofeedback improve neurocognitive functioning in children with attention‐deficit/hyperactivity disorder? A systematic review and a double‐blind placebo‐controlled study

Vollebregt, M. A., van Dongen‐Boomsma, M., Buitelaar, J. K., & Slaats-Willemse, D. I. E. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12143 · Cited by 84 · see citing works

Toward Better Practice of Covariate Adjustment in Analyzing Randomized Clinical Trials

Ye, T., Shao, J., Yi, Y., & Zhao, Q. (2022) · Journal of the American Statistical Association · doi:10.1080/01621459.2022.2049278 · Cited by 78 · see citing works

Preserving the allocation ratio at every allocation with biased coin randomization and minimization in studies with unequal allocation

Kuznetsova, O. M., & Tymofyeyev, Y. (2011) · Statistics in Medicine · doi:10.1002/sim.4447 · Cited by 77 · see citing works

The effectiveness of a weight-loss Mediterranean diet/lifestyle intervention in the management of obstructive sleep apnea: Results of the “MIMOSA” randomized clinical trial

Georgoulis, M., Yiannakouris, N., Kechribari, I., Lamprou, K., Perraki, E., Vagiakis, E., & Kontogianni, M. D. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.08.037 · Cited by 67 · see citing works

Adaptive randomization for balancing over covariates

Hu, F., Hu, Y., Ma, Z., & Rosenberger, W. F. (2014) · Wiley Interdisciplinary Reviews Computational Statistics · doi:10.1002/wics.1309 · Cited by 66 · see citing works

Right dose, right now: bedside, real-time, data-driven, and personalised antibiotic dosing in critically ill patients with sepsis or septic shock—a two-centre randomised clinical trial

Roggeveen, L. F., Guo, T., Fleuren, L. M., Driessen, R. H., Thoral, P., van Hest, R. M., Mathôt, R. A. A., Swart, E. L., de Grooth, H., van den Bogaard, B., et al. (2022) · Critical Care · doi:10.1186/s13054-022-04098-7 · Cited by 59 · see citing works

A Randomized Controlled Trial Evaluating the Efficacy of a Psychoeducation Program for Families of Children and Adolescents With ADHD in the United Kingdom: Results After a 6-Month Follow-Up

Ferrín, M., Perez-Ayala, V., El, S., Lax-Pericall, T., Jacobs, B. W., Bilbow, A., & Taylor, E. A. (2016) · Journal of Attention Disorders · doi:10.1177/1087054715626509 · Cited by 59 · see citing works

Dose-response relationship between weight loss and improvements in obstructive sleep apnea severity after a diet/lifestyle interventions: Secondary analyses of the “MIMOSA” randomized clinical trial

Georgoulis, M., Yiannakouris, N., Kechribari, I., Lamprou, K., Perraki, E., Vagiakis, E., & Kontogianni, M. D. (2022) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.9834 · Cited by 56 · see citing works

Feasibility of personalised remote long-term follow-up of people with cochlear implants: a randomised controlled trial

Cullington, H. E., Kitterick, P. T., Weal, M. J., & Gromada, M. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-019640 · Cited by 53 · see citing works

Racial/ethnic equity in substance use treatment research: the way forward

Burlew, A. K., McCuistian, C. L., & Szapocznik, J. (2021) · Addiction Science & Clinical Practice · doi:10.1186/s13722-021-00256-4 · Cited by 52 · see citing works

A weight-loss Mediterranean diet/lifestyle intervention ameliorates inflammation and oxidative stress in patients with obstructive sleep apnea: results of the “MIMOSA” randomized clinical trial

Georgoulis, M., Yiannakouris, N., Τέντα, Ρ., Fragopoulou, E., Kechribari, I., Lamprou, K., Perraki, E., Vagiakis, E., & Kontogianni, M. D. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02552-w · Cited by 55 · see citing works

Resveratrol and metabolic health in COPD: A proof-of-concept randomized controlled trial

Beijers, R. J. H. C. G., Gosker, H. R., Sanders, K. J. C., de Theije, C. C., KELDERS, M. C. J. M., Clarke, G. A., Cryan, J. F., van den Borst, B., & Schols, A. M. W. J. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.01.002 · Cited by 48 · see citing works

A Randomized Controlled Trial on Mutual Support Group Intervention for Families of People With Recent-Onset Psychosis: A Four-Year Follow-Up

Chien, W. T., Bressington, D. T., & Chan, S. W. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00710 · Cited by 47 · see citing works

Near-Optimal A-B Testing

Bhat, N., Farias, V. F., Moallemi, C. C., & Sinha, D. (2020) · Management Science · doi:10.1287/mnsc.2019.3424 · Cited by 39 · see citing works

Rationale and design of a randomized trial of home electronic symptom and lung function monitoring to detect cystic fibrosis pulmonary exacerbations: The early intervention in cystic fibrosis exacerbation (eICE) trial

Lechtzin, N., West, N. E., Allgood, S., Wilhelm, E., Khan, U., Mayer-Hamblett, N., Aitken, M. L., Ramsey, B. W., Boyle, M., Mogayzel, P. J., et al. (2013) · Contemporary Clinical Trials · doi:10.1016/j.cct.2013.09.004 · Cited by 43 · see citing works

Endovascular treatment for acute ischemic stroke patients: implications and interpretation of IMS III, MR RESCUE, and SYNTHESIS EXPANSION trials: A report from the Working Group of International Congress of Interventional Neurology

Qureshi, A. I., Abd-Allah, F., Aleu, A., Connors, J. J. “., Hanel, R. A., Hassan, A. E., Hussein, H. M., Janjua, N. A., Khatri, R., Kirmani, J. F., et al. (2014) · Europe PMC (PubMed Central) · doi:10.7892/boris.64314 · Cited by 43 · see citing works

The effect of geriatric intervention in frail elderly patients receiving chemotherapy for colorectal cancer: a randomized trial (GERICO)

Lund, C. M., Vistisen, K. K., Dehlendorff, C., Rønholt, F., Johansen, J. S., & Nielsen, D. L. (2017) · BMC Cancer · doi:10.1186/s12885-017-3445-8 · Cited by 42 · see citing works

Inference on the average treatment effect under minimization and other covariate-adaptive randomization methods

Ye, T., Yi, Y., & Shao, J. (2021) · Biometrika · doi:10.1093/biomet/asab015 · Cited by 42 · see citing works

A Positive Psychology–Motivational Interviewing Intervention to Promote Positive Affect and Physical Activity in Type 2 Diabetes: The BEHOLD-8 Controlled Clinical Trial

Huffman, J. C., Golden, J., Massey, C. N., Feig, E. H., Chung, W.-J., Millstein, R. A., Brown, L., Gianangelo, T., Healy, B. C., Wexler, D. J., et al. (2020) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000840 · Cited by 40 · see citing works

Effect of Computer-Based Substance Use Screening and Brief Behavioral Counseling vs Usual Care for Youths in Pediatric Primary Care

Knight, J. R., Sherritt, L., Gibson, E. B., Levinson, J. A., Grubb, L. K., Samuels, R. C., Silva, T., Vernacchio, L., Wornham, W. L., & Harris, S. K. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.6258 · Cited by 38 · see citing works

Right Dose Right Now: bedside data-driven personalized antibiotic dosing in severe sepsis and septic shock — rationale and design of a multicenter randomized controlled superiority trial

Roggeveen, L. F., Fleuren, L. M., Guo, T., Thoral, P. J., de Grooth, H., Swart, E. L., Klausch, T. L. T., van der Voort, P. H. J., Girbes, A. R. J., Bosman, R. J., et al. (2019) · Trials · doi:10.1186/s13063-019-3911-5 · Cited by 33 · see citing works

Brick tunnel randomization for unequal allocation to two or more treatment groups

Kuznetsova, O. M., & Tymofyeyev, Y. (2011) · Statistics in Medicine · doi:10.1002/sim.4167 · Cited by 33 · see citing works

Cardiometabolic Benefits of a Weight-Loss Mediterranean Diet/Lifestyle Intervention in Patients with Obstructive Sleep Apnea: The “MIMOSA” Randomized Clinical Trial

Georgoulis, M., Yiannakouris, N., Kechribari, I., Lamprou, K., Perraki, E., Vagiakis, E., & Kontogianni, M. D. (2020) · Nutrients · doi:10.3390/nu12061570 · Cited by 33 · see citing works

Personalised long-term follow-up of cochlear implant patients using remote care, compared with those on the standard care pathway: study protocol for a feasibility randomised controlled trial

Cullington, H. E., Kitterick, P. T., DeBold, L., Weal, M. J., Clarke, N. M. P., Newberry, E., & Aubert, L. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-011342 · Cited by 31 · see citing works

A randomised controlled trial evaluating the effect of a brief motivational intervention to promote breastfeeding in postpartum depression

Franco-Antonio, C., Santano-Mogena, E., Chimento-Díaz, S., Sánchez-García, P., & Cordovilla-Guardia, S. (2022) · Scientific Reports · doi:10.1038/s41598-021-04338-w · Cited by 29 · see citing works

Mindfulness for children with ADHD and Mindful Parenting (MindChamp): Protocol of a randomised controlled trial comparing a family Mindfulness-Based Intervention as an add-on to care-as-usual with care-as-usual only

Siebelink, N. M., Bögels, S. M., Boerboom, L. M., de Waal, N., Buitelaar, J. K., Speckens, A. E. M., & Greven, C. U. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1811-y · Cited by 28 · see citing works

A pragmatic randomized trial of a primary care antimicrobial stewardship intervention in Ontario, Canada

McIsaac, W. J., Kukan, S., Huszti, E., Szadkowski, L., O’Neill, B. G., Virani, S., Ivers, N. M., Lall, R., Gill, N., Shah, M., et al. (2021) · BMC Family Practice · doi:10.1186/s12875-021-01536-3 · Cited by 29 · see citing works

Dynamic randomization and a randomization model for clinical trials data

Kaiser, L. D. (2012) · Statistics in Medicine · doi:10.1002/sim.5448 · Cited by 26 · see citing works

Mobile mindfulness for psychological distress and burnout among frontline COVID-19 nurses: A pilot randomized trial

Pratt, E. H., Hall, L., Jennings, C., Olsen, M. K., Jan, A., Parish, A., Porter, L. S., & Cox, C. E. (2023) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202301-025oc · Cited by 26 · see citing works

Matching on‐the‐fly: Sequential allocation with higher power and efficiency

Kapelner, A. D., & Krieger, A. Μ. (2014) · Biometrics · doi:10.1111/biom.12148 · Cited by 25 · see citing works

Minimization in randomized clinical trials

Coart, E., Bamps, P., Quinaux, E., Sturbois, G., Saad, E. D., Burzykowski, T., & Buyse, M. E. (2023) · Statistics in Medicine · doi:10.1002/sim.9916 · Cited by 24 · see citing works

Comparing Effects of Treatment: Controlling for Confounding

Yan, H., Karmur, B. S., & Kulkarni, A. V. (2019) · Neurosurgery · doi:10.1093/neuros/nyz509 · Cited by 23 · see citing works

Testing the effects of combining azithromycin with inhaled tobramycin forP. aeruginosain cystic fibrosis: a randomised, controlled clinical trial

Nichols, D. P., Singh, P. K., Baines, A., Caverly, L. J., Chmiel, J. F., Gibson, R. L., Lascano, J. E., Morgan, S. J., Retsch‐Bogart, G. Z., Saiman, L. M., et al. (2021) · Thorax · doi:10.1136/thoraxjnl-2021-217782 · Cited by 21 · see citing works

Feasibility of Mobile App-based Coping Skills Training for Cardiorespiratory Failure Survivors: The Blueprint Pilot Randomized Controlled Trial

Cox, C. E., Kelleher, S. A., Parish, A., Olsen, M. K., Bermejo, S. D., Dempsey, K., Jaggers, J., Hough, C. L., Moss, M., & Porter, L. S. (2023) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202210-890oc · Cited by 19 · see citing works

Practical Considerations and Strategies for Executing Adaptive Clinical Trials

He, W., Kuznetsova, O. M., Harmer, M., Leahy, C., Anderson, K. M., Dossin, N., Li, L., Bolognese, J. A., Tymofyeyev, Y., & Schindler, J. S. (2012) · Drug Information Journal · doi:10.1177/0092861512436580 · Cited by 19 · see citing works

Home Visit Intervention Promotes Lifestyle Changes: Results of an RCT in Mexican Americans

Vidoni, M. L., Lee, M., Mitchell-Bennett, L. A., & Reininger, B. M. (2019) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2019.06.020 · Cited by 19 · see citing works

The safety and effectiveness of low field intraoperative MRI guidance in frameless stereotactic biopsies of brain tumours—design and interim analysis of a prospective randomized trial

Czyz, M., Tabakow, P., Weiser, A., Lechowicz-Głogowska, B., Zub, L., & Jarmundowicz, W. (2013) · Neurosurgical review · doi:10.1007/s10143-013-0486-6 · Cited by 17 · see citing works

Wide brick tunnel randomization – an unequal allocation procedure that limits the imbalance in treatment totals

Kuznetsova, O. M., & Tymofyeyev, Y. (2013) · Statistics in Medicine · doi:10.1002/sim.6051 · Cited by 17 · see citing works

Ranking evidence in substance use and addiction

Reddon, H., Kerr, T. H., & Milloy, M. (2020) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2020.102840 · Cited by 17 · see citing works

Characterizing gut microbial dysbiosis and exploring the effect of prebiotic fiber supplementation in patients with COPD

van Iersel, L. E. J., Beijers, R. J. H. C. G., Simons, S. O., Schuurman, L., Shetty, S. A., Roeselers, G., van Helvoort, A., Schols, A. M. W. J., & Gosker, H. R. (2025) · European Journal of Nutrition · doi:10.1007/s00394-025-03733-7 · Cited by 17 · see citing works

Approaches to expanding the two‐arm biased coin randomization to unequal allocation while preserving the unconditional allocation ratio

Kuznetsova, O. M., & Johnson, V. P. (2017) · Statistics in Medicine · doi:10.1002/sim.7290 · Cited by 16 · see citing works

Neuromodulation to improve gait and balance function using a sensory neuroprosthesis in people who report insensate feet – A randomized control cross-over study

Koehler-McNicholas, S. R., Danzl, L., Cataldo, A. Y., & Oddsson, L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216212 · Cited by 16 · see citing works

Improved diabetes control among low-income Mexican Americans through community-clinical interventions: results of an RCT

Reininger, B. M., Lee, M., Hessabi, M., Mitchell-Bennett, L. A., Sifuentes, M. R., Guerra, J. A., Ayala, C. D., Xu, T., Polletta, V. L., Flynn, A., et al. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000867 · Cited by 15 · see citing works

Optimizing a self-directed mobile mindfulness intervention for improving cardiorespiratory failure survivors' psychological distress (LIFT2): Design and rationale of a randomized factorial experimental clinical trial

Cox, C. E., Olsen, M. K., Gallis, J. A., Porter, L. S., Greeson, J. M., Gremore, T. M., Frear, A., Ungar, A., McKeehan, J. D., McDowell, B., et al. (2020) · Contemporary Clinical Trials · doi:10.1016/j.cct.2020.106119 · Cited by 16 · see citing works

Generalized multidimensional dynamic allocation method

Lebowitsch, J., Ge, Y., Young, B. F., & Hu, F. (2012) · Statistics in Medicine · doi:10.1002/sim.5418 · Cited by 14 · see citing works

Immediate Effects of Clock-Turn Strategy on the Pattern and Performance of Narrow Turning in Persons With Parkinson Disease

Yang, W., Hsu, W., Wu, R., & Lin, K.-H. (2016) · Neurology Report · doi:10.1097/npt.0000000000000148 · Cited by 13 · see citing works

Endoscopic third ventriculostomy before surgery of third ventricle and posterior fossa tumours decreases the risk of secondary hydrocephalus and early postoperative complications

Tabakow, P., Weiser, A., Burzyńska, M., & Błauciak, P. (2021) · Neurosurgical Review · doi:10.1007/s10143-021-01570-w · Cited by 13 · see citing works

CORE-Hom: A powerful and exhaustive database of clinical trials in homeopathy

Clausen, J., Moss, S., Tournier, A., Lüdtke, R., & Albrecht, H. (2014) · Homeopathy · doi:10.1016/j.homp.2014.07.001 · Cited by 13 · see citing works

Inference on Average Treatment Effect under Minimization and Other Covariate-Adaptive Randomization MethodsPreprint

Ye, T., Yi, Y., & Shao, J. (2020) · arXiv (Cornell University) · doi:10.48550/arxiv.2007.09576 · Cited by 13 · see citing works

Possible Combinations of Electronic Data Capture and Randomization Systems

Haag, M., Pilz, L. R., & Schrimpf, D. (2014) · Methods of Information in Medicine · doi:10.3414/me13-01-0074 · Cited by 12 · see citing works

Oral Glutathione and Growth in Cystic Fibrosis

Bozic, M. A., Goss, C. H., Tirouvanziam, R. M., Baines, A., Kloster, M., Antoine, L., Borowitz, D., Schwarzenberg, S. J., & GROW study group (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002948 · Cited by 11 · see citing works

Inference after covariate-adaptive randomisation: aspects of methodology and theory

Shao, J. (2021) · Statistical Theory and Related Fields · doi:10.1080/24754269.2021.1871873 · Cited by 11 · see citing works

Effect of targeted nutrient supplementation on physical activity and health-related quality of life in COPD: study protocol for the randomised controlled NUTRECOVER trial

Beijers, R. J. H. C. G., van Iersel, L. E. J., Schuurman, L., Hageman, R. J. J., Simons, S. O., van Helvoort, A., Gosker, H. R., & Schols, A. M. W. J. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-059252 · Cited by 12 · see citing works

A REDCap advanced randomization module to meet the needs of modern trials

Stevens, L., Kennedy, N., Taylor, R. J., Lewis, A., Harrell, F. E., Shotwell, M. S., Serdoz, E. S., Bernard, G. R., Self, W. H., Lindsell, C. J., et al. (2025) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2025.104925 · Cited by 10 · see citing works

A randomized controlled trial to evaluate the effectiveness of a brief motivational intervention to improve exclusive breastfeeding rates: Study protocol

Franco‐Antonio, C., García, J. F. C., Vilar‐López, R., Portillo‐Santamaría, M., Navas, J. F., & Cordovilla‐Guardia, S. (2018) · Journal of Advanced Nursing · doi:10.1111/jan.13917 · Cited by 10 · see citing works

Optimal positive end-expiratory pressure obtained with titration of a fraction of inspiratory oxygen: a randomized controlled clinical trial

Gao, L., Yang, L., Pan, L., Cui, Y., & Zhang, J. (2023) · Annals of Translational Medicine · doi:10.21037/atm-22-4357 · Cited by 9 · see citing works

Feasibility and Efficacy of the Nintendo Wii Gaming System to Improve Balance Performance Post-Stroke: Protocol of a Phase II Randomized Controlled Trial in an Inpatient Rehabilitation Setting

Bower, K. J., Clark, R. A., McGinley, J. L., Martin, C. L., & Miller, K. J. (2013) · Games for Health Journal · doi:10.1089/g4h.2012.0069 · Cited by 9 · see citing works

Finding the optimal regimen for Mycobacteroides abscessus treatment (FORMaT) in people with Mycobacteroides abscessus pulmonary disease: a multicentre, randomised, multi-arm, adaptive platform trial

Jong, T., Baird, T., Barr, H. L., Bell, S. C., Bigirumurame, T., Brady, K., Burke, A., Byrnes, J., Caudri, D., Clark, J. E., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-096188 · Cited by 8 · see citing works

Regression-Based Multiple Treatment Effect Estimation under Covariate-Adaptive Randomization

Gu, Y., Liu, H., & Ma, W. (2023) · Biometrics · doi:10.1111/biom.13925 · Cited by 7 · see citing works

Indentation marks, skin temperature and comfort of two cervical collars: A single-blinded randomized controlled trial in healthy volunteers

Leenen, J. P. L., Ham, W. H. W., & Leenen, L. P. H. (2020) · International Emergency Nursing · doi:10.1016/j.ienj.2020.100878 · Cited by 7 · see citing works

Weighted re‐randomization tests for minimization with unbalanced allocation

Han, B., Yu, M., & McEntegart, D. J. (2013) · Pharmaceutical Statistics · doi:10.1002/pst.1577 · Cited by 7 · see citing works

Exploring the feasibility and impact of positive psychology-motivational interviewing interventions to promote positive affect and physical activity in type 2 diabetes: design and methods from the BEHOLD-8 and BEHOLD-16 clinical trials

Zambrano, J., Celano, C. M., Chung, W., Massey, C. N., Feig, E. H., Millstein, R. A., Healy, B. C., Wexler, D. J., Park, E. R., Golden, J., et al. (2020) · Health Psychology and Behavioral Medicine · doi:10.1080/21642850.2020.1815538 · Cited by 7 · see citing works

Data Collection and Management of mHealth, Wearables, and Internet of Things in Digital Behavioral Health Interventions With the Awesome Data Acquisition Method (ADAM): Development of a Novel Informatics Architecture

Pulantara, I. W., Wang, Y., Burke, L. E., Sereika, S. M., Bizhanova, Z., Kariuki, J. K., Cheng, J. S.-C., Beatrice, B., Loar, I., Cedillo, M., et al. (2024) · JMIR mhealth and uhealth · doi:10.2196/50043 · Cited by 6 · see citing works

A matching procedure for sequential experiments that iteratively learns which covariates improve power

Kapelner, A. D., & Krieger, A. Μ. (2021) · Biometrics · doi:10.1111/biom.13561 · Cited by 6 · see citing works

An adaptive text message intervention to promote psychological well-being and reduce cardiac risk: The Text4Health controlled clinical pilot trial

Celano, C. M., Healy, B. C., Jacobson, L. H., Bell, M., Carrillo, A., Massey, C. N., Chung, W., Legler, S. R., & Huffman, J. C. (2023) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2023.111583 · Cited by 6 · see citing works

Comparison of Pocock and Simon’s covariate-adaptive randomization procedures in clinical trials

Shan, G., Li, Y., Lu, X., Zhang, Y., & Wu, S. S. (2024) · BMC Medical Research Methodology · doi:10.1186/s12874-024-02151-3 · Cited by 6 · see citing works

High-density transcranial direct current stimulation to improve upper limb motor function following stroke: study protocol for a double-blind randomized clinical trial targeting prefrontal and/or cerebellar cognitive contributions to voluntary motion

Corominas-Teruel, X., Bracco, M., Fibla, M., Segundo, R. M. S., Villalobos-Llaó, M., Galléa, C., Béranger, B., Toba, M. N., Valero‐Cabré, A., & Colomina, M. T. (2023) · Trials · doi:10.1186/s13063-023-07680-8 · Cited by 5 · see citing works

Proof of concept and design of an externally controlled trial for patients with gastro-enteropancreatic neuroendocrine carcinomas based on the randomized phase II BEVANEC trial

Ganame, S., Walter, T., Durand, A., Lièvre, A., Tougeron, D., Scoazec, J., Baudin, É., Lepage, C., Boussari, O., & Hadoux, J. (2025) · European Journal of Cancer · doi:10.1016/j.ejca.2025.115450 · Cited by 5 · see citing works

Brick tunnel randomization and the momentum of the probability mass

Kuznetsova, O. M. (2015) · Statistics in Medicine · doi:10.1002/sim.6601 · Cited by 5 · see citing works

Evaluation of Acebilustat, a Selective Inhibitor of Leukotriene B4 Biosynthesis, for Treatment of Outpatients With Mild-Moderate Coronavirus Disease 2019: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial

Levitt, J. E., Hedlin, H., Duong, S., Lu, D., Lee, J., Bunning, B., Elkarra, N., Pinsky, B. A., Heffernan, E., Springman, E. B., et al. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciad187 · Cited by 5 · see citing works

Generalized Efron's biased coin design and its theoretical properties

Hu, Y. (2016) · Journal of Applied Probability · doi:10.1017/jpr.2016.3 · Cited by 5 · see citing works

Assessment of Leg Massage on Hemodynamic Parameters of Intensive Care Patients: A Parallel Single-Blinded Randomized Controlled Trial

Momeni, M., Arab, M., Dehghan, M., & Ahmadinejad, M. (2020) · Journal of Chiropractic Medicine · doi:10.1016/j.jcm.2020.02.003 · Cited by 5 · see citing works

Program for Healthier School Cafeterias in Rio Grande do Sul, Brazil: Protocol for a Community-Based Randomized Trial

Balestrin, M., Brasil, C. C. B., Bellei, E. A., Kirsten, V. R., & Wagner, M. B. (2021) · JMIR Research Protocols · doi:10.2196/22680 · Cited by 5 · see citing works

Principles for Covariate Adjustment in Analyzing Randomized Clinical TrialsPreprint

Ye, T., Shao, J., & Zhao, Q. (2020) · arXiv (Cornell University) · Cited by 4 · see citing works

Randomization in the age of platform trials: unexplored challenges and some potential solutions

Kuznetsova, O. M., Ross, J., Bodden, D., Cooner, F., Chipman, J., Jacko, P., Krisam, J., Luo, Y., Mielke, T., Robertson, D. S., et al. (2025) · BMC Medical Research Methodology · doi:10.1186/s12874-025-02693-0 · Cited by 3 · see citing works

Issues for stratified randomization based on a factor derived from a continuous baseline variable

Qu, Y. (2010) · Pharmaceutical Statistics · doi:10.1002/pst.453 · Cited by 3 · see citing works

Computer-Facilitated Screening and Brief Intervention for Alcohol Use Risk in Adolescent Patients of Pediatric Primary Care Offices: Protocol for a Cluster Randomized Controlled Trial

Shrier, L. A., O’Connell, M., Torres, A., Shone, L. P., Fiks, A. G., Plumb, J. A., Maturo, J. L., McCaskill, N. H., Harris, D. L., Burke, P. J., et al. (2024) · JMIR Research Protocols · doi:10.2196/55039 · Cited by 3 · see citing works

The regional ventilation distribution monitored by electrical impedance tomography during anesthesia induction with head-rotated mask ventilation

Xu, Q., Fang, Y., Pan, C., Gao, L., Zhu, Y., Zhang, J., Zhao, Z., & Yang, L. (2025) · Physiological Measurement · doi:10.1088/1361-6579/adad2f · Cited by 3 · see citing works

Sequence balance minimisation: minimising with unequal treatment allocations

Madurasinghe, V. (2017) · Trials · doi:10.1186/s13063-017-1942-3 · Cited by 3 · see citing works

Hierarchical Dynamic Allocation Procedures Based on Modified Zelen’s Approach in Multiregional Studies With Unequal Allocation

Kuznetsova, O. M., & Tymofyeyev, Y. (2014) · Journal of Biopharmaceutical Statistics · doi:10.1080/10543406.2014.900783 · Cited by 3 · see citing works

Electrophysiological predictors and indicators of contingency management treatment response: Rationale and design for the ways of rewarding abstinence project (WRAP)

Förster, S., Forman, S. D., Gancz, N. N., Siegle, G. J., Dickey, M. W., & Steinhauer, S. R. (2021) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2021.100796 · Cited by 3 · see citing works

The properties of covariate-adaptive randomization procedures with possibly unequal allocation ratio

Liu, X. J., Hu, F., & Ma, W. (2025) · The Annals of Applied Statistics · doi:10.1214/25-aoas2023 · Cited by 2 · see citing works

Intraoperative titration of positive end-expiratory pressure in urological patients undergoing laparoscopic procedures under lateral position: a randomized controlled trial

Pan, L., Wu, X., Gao, L., Zhao, Z., Yang, L., & Zhang, J. (2025) · BMC Anesthesiology · doi:10.1186/s12871-025-03171-2 · Cited by 2 · see citing works

Randomization Challenges in Adaptive Design Studies

Kuznetsova, O. M. (2014) · Statistics for biology and health · doi:10.1007/978-1-4939-1100-4_9 · Cited by 2 · see citing works

Evidence-based urology: how does a randomized clinical trial achieve its designed goals?

Sadeghi‐Bazargani, H., & Hajebrahimi, S. (2011) · PubMed · Cited by 2 · see citing works

Shortening of treatment duration in patients with chronic hepatitis C genotype 2 and 3 - impact of ribavirin dose - a randomized multicentre trial

Maieron, A., Metz-Gercek, S., Scherzer, T. M., Laferl, H., Fischer, G., Bischof, M. G., Gschwantler, M., & Ferenci, P. (2011) · BMC Research Notes · doi:10.1186/1756-0500-4-220 · Cited by 1 · see citing works

Statistical Analysis and Design of Crowdsourcing Applications

Kapelner, A. D. (2014) · ScholarlyCommons (University of Pennsylvania) · Cited by 1 · see citing works

Optimal Positive End-Expiratory Pressure Obtained with Titration of Fraction of Inspiratory Oxygen: A Randomized Controlled Clinical TrialPreprint

Gao, L., Yang, L., Pan, L., Cui, Y., Jiang, Y., & Zhang, J. (2021) · Research Square · doi:10.21203/rs.3.rs-1078756/v1 · Cited by 1 · see citing works

Matching on-the-fly in Sequential Experiments for Higher Power and EfficiencyPreprint

Kapelner, A. D., & Krieger, A. Μ. (2013) · arXiv (Cornell University) · doi:10.48550/arxiv.1305.4981

Validade preditiva de métodos para a avaliação da atividade das lesões de cárie em dentes decíduos

Martins, I. F. N. (2014) · doi:10.11606/d.23.2014.tde-11072014-152800

Impacto da detecção de lesões iniciais e da avaliação da atividade de cárie em dentes decíduos: estudo controlado randomizado (CARDEC-02) com 1 ano de seguimento

Martins, I. F. N. (2018) · doi:10.11606/t.23.2018.tde-27112017-121756

Algorithms for minimization randomization and the implementation with an R package

Jin, M., Polis, A. B., & Hartzel, J. S. (2019) · Communications in Statistics - Simulation and Computation · doi:10.1080/03610918.2019.1619765 · Cited by 32 · see citing works

The method of minimization for allocation to clinical trials

Scott, N. W., McPherson, G. C., Ramsay, C. R., & Campbell, M. K. (2002) · Controlled Clinical Trials · doi:10.1016/s0197-2456(02)00242-8 · Cited by 651 · see citing works

Minimize the Use of Minimization with Unequal Allocation

Proschan, M. A., Brittain, E., & Kammerman, L. A. (2011) · Biometrics · doi:10.1111/j.1541-0420.2010.01545.x · Cited by 46 · see citing works

The role of minimisation in treatment allocation for clinical trials

McPherson, G. C. (2011) · OpenGrey (Institut de l'Information Scientifique et Technique)

Studywise minimization: A treatment allocation method that improves balance among treatment groups and makes allocation unpredictable

Perry, M., Faes, M. C., Reelick, M. F., Rikkert, M. G. M. O., & Borm, G. F. (2010) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.11.014 · Cited by 30 · see citing works