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Cited by 194

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Ultrasmall Near‐Infrared Non‐cadmium Quantum Dots for in vivo Tumor Imaging

Open access
Gao, Jinhao, Chen, Kai, Xie, Renguo, Xie, Jin, Lee, Seulki, Cheng, Zhen, Peng, Xiaogang, Chen, Xiaoyuan·2010·Small

Abstract

The high tumor uptake of ultrasmall near‐infrared quantum dots (QDs) attributed to the enhanced permeability and retention effect is reported. InAs/InP/ZnSe QDs coated by mercaptopropionic acid (MPA) exhibit an emission wavelength of about 800 nm (QD800‐MPA) with very small hydrodynamic diameter (<10 nm). Using 22B and LS174T tumor xenograft models, in vivo and ex vivo imaging studies show that QD800‐MPA is highly accumulated in the tumor area, which is very promising for tumor detection in living mice. The ex vivo elemental analysis (Indium) using inductively coupled plasma (ICP) spectrometry confirm the tumor uptake of QDs. The ICP data are consistent with the in vivo and ex vivo fluorescence imaging. Human serum albumin (HSA)‐coated QD800‐MPA nanoparticles (QD800‐MPA‐HSA) show reduced localization in mononuclear phagocytic system‐related organs over QD800‐MPA plausibly due to the low uptake of QD800‐MPA‐HSA in macrophage cells. QD800‐MPA‐HSA may have great potential for in vivo fluorescence imaging.

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Metadata

Authors
Gao, J., Chen, K., Xie, R., Xie, J., Lee, S., Cheng, Z., Peng, X., & Chen, X.
Venue
Small
Publisher
Wiley
Published
2010-01-14
Volume
6
Issue
2
Pages
256-261
ISSN
  • 1613-6810 (ISSN-L)
  • 1613-6829
OpenAlex
W2098232125
Cited by
194
References
3
FWCI
8.61
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Ultrasmall Near‐Infrared Non‐cadmium Quantum Dots for in vivo Tumor Imaging. https://app.cochat.ai/papers/10.1002/smll.200901672
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Gao, J., Chen, K., Xie, R., Xie, J., Lee, S., Cheng, Z., Peng, X., & Chen, X. (2010). Ultrasmall Near‐Infrared Non‐cadmium Quantum Dots for in vivo Tumor Imaging. Small. https://doi.org/10.1002/smll.200901672

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