Quantum‐Dot‐Encoded Silica Nanospheres for Nucleic Acid Hybridization
Abstract
Oligonucleotide-modified submicrometer-sized silica nanospheres that are color-encoded by embedded luminescent QDs and that can be further functionalized by DNA–protein conjugates are described. This approach provides a facile route to specifically encode and functionalize particles for biological and biomedical applications.
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Using hybridization assays with fluorescently-labelled probes, the authors estimated the number of barcodes available for hybridization on each file to be on the order of 10^8.
“Using hybridization assays with fluorescently-labelled probes35–37, we estimated the number of barcodes available for hybridization on each file to be on the order of 108 (Supplementary Fig. 7).”
From Random access DNA memory using Boolean search in an archival file storage system (2021) · cites this paper as [35]
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Self-citation
- Authors
- Pillai, P. P., Reisewitz, S., Schroeder, H., & Niemeyer, C. M.
- Affiliations
- TU Dortmund University (DE)
- Corresponding author
- Niemeyer, Christof M.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2010-09-02
- Volume
- 6
- Issue
- 19
- Pages
- 2130-2134
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W2076785222
- Cited by
- 25
- References
- 32
- Citations by year
- 2025: 3 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 4
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Small (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alexander von Humboldt-Stiftung
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Keywords
- quantum dots, silica nanospheres, nucleic acid hybridization, luminescent quantum dots, protein-DNA conjugates, particle functionalization, submicron particles
- MeSH terms
- Luminescent Measurements, Nucleic Acid Hybridization, Silicon Dioxide, Quantum Dots, Nanospheres
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