The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
NIR Photoresponsive Crosslinked Upconverting Nanocarriers Toward Selective Intracellular Drug Release
Abstract
An NIR‐responsive mesoporous silica coated upconverting nanoparticle (UCNP) conjugate is developed for controllable drug delivery and fluorescence imaging in living cells. In this work, antitumor drug doxorubicin (Dox) molecules are encapsulated within cross‐linked photocaged mesoporous silica coated UCNPs. Upon 980 nm light irradiation, Dox could be selectively released through the photocleavage of the o‐nitrobenzyl (NB) caged linker by the converted UV emission from UCNPs. This NIR light‐responsive nanoparticle conjugate demonstrates high efficiency for the controlled release of the drug in cancer cells. Upon functionalization of the nanocarrier with folic acid (FA), this photocaged FA‐conjugated silica‐UCNP nanocarrier will also allow targeted intracellular drug delivery and selective fluorescence imaging towards the cell lines with high level expression of folate receptor (FR).
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Cites
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Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558
Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties
Kloxin, A. M., Kasko, A. M., Salinas, C. N., & Anseth, K. S. (2009) · Science · doi:10.1126/science.1169494 · Cited by 1,748
Yang, Y., Liu, F., Liu, X., & Xing, B. (2013) · Nanoscale · doi:10.1039/c2nr32835f · Cited by 229
Self-citation
Cited by
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
Chen, G., Qiu, H., Prasad, P. N., & Chen, X. (2014) · Chemical Reviews · doi:10.1021/cr400425h · Cited by 2,699
Controlling upconversion nanocrystals for emerging applications
Zhou, B., Shi, B., Jin, D., & Liu, X. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.251 · Cited by 1,503
Self-citationZheng, W., Huang, P., Tu, D., Ma, E., Zhu, H., & Chen, X. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00178h · Cited by 894
Current advances in lanthanide ion (Ln3+)-based upconversion nanomaterials for drug delivery
Yang, D., Ma, P., Hou, Z., Cheng, Z., Li, C., & Lin, J. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00155a · Cited by 743
Near‐Infrared‐Sensitive Materials Based on Upconverting Nanoparticles
Wu, S., & Butt, H. (2016) · Advanced Materials · doi:10.1002/adma.201502843 · Cited by 417
Metadata
- Authors
- Yang, Y., Velmurugan, B., Liu, X., & Xing, B.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2013-04-02
- Volume
- 9
- Issue
- 17
- Pages
- 2937-2944
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W1974970463
- Cited by
- 183
- References
- 5
- FWCI
- 9.94
- Type
- journal article
- Language
- en
- Open access
- closed
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