Bioactive calcium hydride-driving “triple” hydrogen/alkaline/calcium therapy for efficient treatment of osteomyelitis
Abstract
Abstract Osteomyelitis with high mortality and disability rates is a common clinical disease caused by a bacterial infection that is difficult to cure. Considering the stubborn nature and depth of tissue infection, rapid and effective treatments for osteomyelitis remain an enormous challenge. Calcium hydride (CaH 2 ), as efficient hydrogen/alkaline/calcium donors, is employed for combined osteomyelitis therapy. CaH 2 reacts with water to sufficiently generate a strong alkali environment with hydroxide anions (OH − ) to inhibit bacterial proliferation and induce bacterial death. The released calcium ions (Ca 2+ ) induce calcium overload to kill bacteria first and then serves as calcium source to promote new bone formation. Another byproduct, hydrogen enhances the bacterial membrane permeability and scavenges excess reactive oxygen species (ROS). After incubation with bacteria, CaH 2 significantly increases the permeability of the bacterial membrane, therefore increasing the entry of OH − and Ca 2+ into bacterial cells, thereby leading to significant bacterial death. After being applied to S. aureus ‐infected mouse tibia osteomyelitis, CaH 2 materials efficiently kill bacteria, relieve local inflammation, and promote new bone formation in a short time. Overall, bioactive metal hydride‐associated “triple” hydrogen/alkaline/calcium therapy provides a new idea for the treatment of deep‐site bacterial infection, which is beneficial for relieving the pressure caused by antibiotic‐resistant bacteria.
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Uncoated Mg reduced microbial adhesion significantly, likely due to release of corrosion products (Zn2+/H2/OH−).
“Uncoated Mg also reduced microbial adhesion significantly, likely owing to the release of corrosion products (Zn2+/H2/OH−) during rapid corrosion [[29], [30], [31]].”
From Nanocatalytic magnesium osteoimplants with biodegradable self-adaptive interfaces for therapeutic repair of infected bone defects (2026) · cites this paper as [31]
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- Authors
- Chen, L., Cheng, S., Lu, S., Gao, X., Gong, F., Shi, J., Han, Z., Wang, Y., Yang, X., Zhou, X., & Cheng, L.
- Affiliations
- Wenzhou Central Hospital (CN)
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Macau University of Science and Technology (MO)
- Corresponding author
- Gong, Fei
- Zhou, Xiaozhong
- Cheng, Liang
- Venue
- Small
- Publisher
- Wiley
- Published
- 2024-06-22
- Volume
- 20
- Issue
- 43
- Pages
- e2306315-e2306315
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W4399918821
- Cited by
- 12
- References
- 43
- Citations by year
- 2026: 2 · 2025: 10
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Small (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (U20A20254, 52072253, 52203362, 81873995, 82172425)
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Higher Education Discipline Innovation Project
- China Postdoctoral Science Foundation (2021TQ0229, 2021M702381)
- Topics
- Health Sciences › Medicine › Surgery › Orthopedic Infections and Treatments
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Hydrogen's biological and therapeutic effects
- Keywords
- osteomyelitis, calcium hydride, metal hydrides, hydrogen treatment, alkali therapy, calcium ions, bacterial membrane permeability, reactive oxygen species scavenging, Staphylococcus aureus, antibiotic resistance, bone regeneration, deep tissue infection, hydroxide ion
- MeSH terms
- Animals, Calcium, Calcium Hydroxide, Hydrogen, Osteomyelitis, Staphylococcus aureus, Mice
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