Magnesium implants with alternating magnetic field-enhanced hydrogen release and proton depletion for anti-infection treatment and tissue repair
Open accessAbstract
Implant-related osteomyelitis is a formidable hurdle in the clinical setting and is characterized by inflammation, infection, and consequential bone destruction. Therefore, effective reactive oxygen species (ROS) scavenging, bacterial killing, and subsequent bone tissue repair are urgently needed for the treatment of difficult-to-heal osteomyelitis. Herein, we utilized the eddy-thermal effect of magnesium (Mg) implants under an alternating magnetic field (AMF) for the controlled release of H2 gas and ions (OH− and Mg2+) for the treatment of osteomyelitis. H2 released by Mg rods under AMFs effectively scavenged cytotoxic ROS, exhibiting anti-inflammatory effects and consequently disrupting the environment of bacterial infections. In addition, the OH− hindered the energy metabolism of bacteria by effectively neutralizing protons within the microenvironment. Moreover, H2 impaired the permeability of bacterial membranes and expedited the damage induced by OH−. This synergistic AMF-induced H2 and proton depletion treatment approach not only killed both gram-negative and gram-positive bacteria but also effectively treated bacterial infections (abscesses and osteomyelitis). Moreover, Mg2+ released from the Mg rods enhanced and accelerated the process of bone osteogenesis. Overall, our work cleverly exploited the eddy-thermal effect and chemical activity of Mg implants under AMFs, aiming to eliminate the inflammatory environment and combat bacterial infections by the simultaneous release of H2, OH−, and Mg2+, thereby facilitating tissue regeneration. This therapeutic strategy achieved multiple benefits in one, thus presenting a promising avenue for clinical application.
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The ARG1 upregulation in the bare Mg group is likely attributable to localized release of H2 and Mg2+ that can mediate anti-inflammatory gene expression.
“likely attributable to localized release of H2 and Mg2+ that can mediate anti-inflammatory gene expression [63,64].”
From Nanocatalytic magnesium osteoimplants with biodegradable self-adaptive interfaces for therapeutic repair of infected bone defects (2026) · cites this paper as [63]
The Results and discussion sections on H₂ generation and in vivo abscess treatment (page unavailable) report H₂ and Mg²⁺ release from Mg rods and increased anti-inflammatory cytokines in the Mg + AMF group. They do not report ARG1 upregulation in a bare-Mg group or establish that Mg²⁺ release mediated anti-inflammatory gene expression there. (LLM, conf=0.86)
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Zhao, Y., Zhu, G., 张梦雪, Wu, Y., Su, J., Hu, J., Jian, C., & Yuan, Y. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1935416
Tian, J., Wu, Q., Yang, C., Zhang, X., Liu, X., & Wang, W. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.10.038
- Authors
- Yang, N., Yang, X., Cheng, S., Gao, X., Sun, S., Huang, X., Ge, J., Han, Z., Huang, C., Wang, Y., Cheng, C., & Cheng, L.
- Affiliations
- Macau University of Science and Technology (MO)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Corresponding author
- Cheng, Liang
- Venue
- Bioactive Materials
- Publisher
- Elsevier BV
- Published
- 2024-08
- Volume
- 38
- Pages
- 374-383
- ISSN
- 2097-1192 (ISSN-L)
- 2452-199X
- PMC
- PMC11103218
- OpenAlex
- W4396802173
- Cited by
- 38
- References
- 52
- Citations by year
- 2026: 6 · 2025: 25 · 2024: 7
- FWCI
- 16.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Bioactive Materials (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Surgery › Hydrogen's biological and therapeutic effects
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Health Sciences › Medicine › Surgery › Orthopedic Infections and Treatments
- Keywords
- magnesium implants, alternating magnetic field, hydrogen release, reactive oxygen species scavenging, bacterial membrane permeability, bone regeneration, anti-inflammatory activity, bacterial energy metabolism, antimicrobial therapy, tissue regeneration
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