The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Intra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial
Abstract
Mesenchymal stem cells (MSCs) are known to have a potential for articular cartilage regeneration. However, most studies focused on focal cartilage defect through surgical implantation. For the treatment of generalized cartilage loss in osteoarthritis, an alternative delivery strategy would be more appropriate. The purpose of this study was to assess the safety and efficacy of intra-articular injection of autologous adipose tissue derived MSCs (AD-MSCs) for knee osteoarthritis. We enrolled 18 patients with osteoarthritis of the knee and injected AD MSCs into the knee. The phase I study consists of three dose-escalation cohorts; the low-dose (1.0 × 10(7) cells), mid-dose (5.0 × 10(7)), and high-dose (1.0 × 10(8)) group with three patients each. The phase II included nine patients receiving the high-dose. The primary outcomes were the safety and the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) at 6 months. Secondary outcomes included clinical, radiological, arthroscopic, and histological evaluations. There was no treatment-related adverse event. The WOMAC score improved at 6 months after injection in the high-dose group. The size of cartilage defect decreased while the volume of cartilage increased in the medial femoral and tibial condyles of the high-dose group. Arthroscopy showed that the size of cartilage defect decreased in the medial femoral and medial tibial condyles of the high-dose group. Histology demonstrated thick, hyaline-like cartilage regeneration. These results showed that intra-articular injection of 1.0 × 10(8) AD MSCs into the osteoarthritic knee improved function and pain of the knee joint without causing adverse events, and reduced cartilage defects by regeneration of hyaline-like articular cartilage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Multiple Imputation for Nonresponse in Surveys
Rubin, D. B. (1987) · Wiley Series in Probability and Statistics · doi:10.1002/9780470316696 · Cited by 20,701
Kern, S., Eichler, H., Stoeve, J., Klüter, H., & Bieback, K. (2006) · STEM CELLS · doi:10.1634/stemcells.2005-0342 · Cited by 3,370
Mesenchymal stem cells as trophic mediators
Caplan, A. I., & Dennis, J. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20886 · Cited by 2,992
Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells
Rehman, J., Traktuev, D., Li, J., Merfeld-Clauss, S., Temm-Grove, C. J., Bovenkerk, J. E., Pell, C. L., Johnstone, B. H., Considine, R. V., & March, K. L. (2004) · Circulation · doi:10.1161/01.cir.0000121425.42966.f1 · Cited by 2,269
Mesenchymal Stem Cell Homing: The Devil Is in the Details
Karp, J. M., & Leng Teo, G. S. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.02.001 · Cited by 1,445
Cited by
Lee, W.-S., Kim, H. J., Kim, K.-I., Kim, G. B., & Jin, W. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0122 · Cited by 497
Self-citationLiang, Y., Xu, X., Li, X., Xiong, J., Li, B., Duan, L., Wang, D., & Xia, J. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c10458 · Cited by 391
Mesenchymal stem cells: Amazing remedies for bone and cartilage defects
Kangari, P., Talaei-Khozani, T., Razeghian-Jahromi, I., & Razmkhah, M. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02001-1 · Cited by 286
Exosomes and stem cells in degenerative disease diagnosis and therapy
Chang, Y.-H., Wu, K.-C., Harn, H.-J., Lin, S.-Z., & Ding, D.-C. (2018) · Cell Transplantation · doi:10.1177/0963689717723636 · Cited by 159
Bastos, R., Mathias, M., Andrade, R., Amaral, R. J. F. C., Schott, V., Balduino, A., Bastos, R., Miguel Oliveira, J., Reis, R. L., Rodeo, S., et al. (2020) · Knee Surgery, Sports Traumatology, Arthroscopy · doi:10.1007/s00167-019-05732-8 · Cited by 117
Lamo-Espinosa, J. M., Blanco, J. F., Sánchez, M., Moreno, V., Granero-Moltó, F., Sánchez-Guijo, F., Crespo-Cullel, Í., Mora, G., San Vicente, D. D., Pompei-Fernández, O., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02530-6 · Cited by 118
Nguyen, P. D., Tran, T. D.-X., Nguyen, H. T.-N., Vu, H. T., Le, P. T.-B., Phan, N. L.-C., Vu, N. B., Phan, N. K., & Van Pham, P. (2017) · Stem Cells Translational Medicine · doi:10.5966/sctm.2016-0023 · Cited by 112
Li, J., Huang, Y., Song, J., Li, X., Zhang, X., Zhou, Z., Chen, D., Ma, P. X., Peng, W., Wang, W., et al. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.08.029 · Cited by 86
Nicolay, N. H., Perez, R. L., Rühle, A., Trinh, T., Sisombath, S., Weber, K.-J., Ho, A. D., Debus, J., Saffrich, R., & Huber, P. E. (2016) · Scientific Reports · doi:10.1038/srep20035 · Cited by 41
Mesenchymal Stromal Cells for Aging Cartilage Regeneration: A Review
Wu, K.-C., Chang, Y.-H., Ding, D.-C., & Lin, S.-Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312911 · Cited by 33
Eder, C., Schmidt-Bleek, K., Geissler, S., Sass, F. A., Maleitzke, T., Pumberger, M., Perka, C., Duda, G. N., & Winkler, T. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05428-0 · Cited by 33
Universal or Personalized Mesenchymal Stem Cell Therapies: Impact of Age, Sex, and Biological Source
Carp, D. M., & Liang, Y. (2022) · Cells · doi:10.3390/cells11132077 · Cited by 29
Piuzzi, N. S., Emara, A., Chahla, J., & Mandelbaum, B. R. (2020) · Current Reviews in Musculoskeletal Medicine · doi:10.1007/s12178-020-09647-7 · Cited by 21
Tsubosaka, M., Matsumoto, T., Sobajima, S., Matsushita, T., Iwaguro, H., & Kuroda, R. (2021) · Cell Transplantation · doi:10.1177/09636897211067454 · Cited by 21
Metadata
- Authors
- Jo, C. H., Lee, Y. G., Shin, W. H., Kim, H., Chai, J. W., Jeong, E. C., Kim, J. E., Shim, H., Shin, J. S., Shin, I. S., Ra, J. C., Oh, S., & Yoon, K. S.
- Venue
- STEM CELLS
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-04-17
- Volume
- 32
- Issue
- 5
- Pages
- 1254-1266
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W1650284538
- Cited by
- 911
- References
- 5
- FWCI
- 56.54
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
