Exosomes and stem cells in degenerative disease diagnosis and therapy

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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Staging of brain pathology related to sporadic Parkinson’s disease

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Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

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Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

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A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke

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Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke

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Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection

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Mechanisms of angiogenesis

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Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

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Overdependence on degraded gist memory in Alzheimer's disease.

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Epidemiology of Parkinson's disease

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Membrane vesicles as conveyors of immune responses

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B lymphocytes secrete antigen-presenting vesicles.

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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>

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Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

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Mesenchymal stem cells as trophic mediators

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Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

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Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

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Osteoarthritis: New Insights. Part 1: The Disease and Its Risk Factors

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Treatment Strategies for Acute Ischemic Stroke Caused by Carotid Artery Occlusion

Li, W., Yin, Q., Xu, G., & Liu, X. (2016) · Interventional Neurology · doi:10.1159/000445304 · Cited by 2,319 · see citing works

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

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Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

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Intra-Arterial Mechanical Thrombectomy: An Effective Treatment for Ischemic Stroke Caused by Endocarditis

Sveinsson, O. A., Herrman, L., & Holmin, S. (2016) · Case Reports in Neurology · doi:10.1159/000452213 · Cited by 2,037 · see citing works

Exosomes as drug delivery vehicles for Parkinson’s disease therapy

Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., Patel, T., Piroyan, A., Sokolsky, M., Kabanov, A. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.033 · Cited by 2,009 · see citing works

Adult mesenchymal stem cells for tissue engineering versus regenerative medicine

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Parkinson's disease

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Negative Fluid-Attenuated Inversion Recovery- Based Intravenous Thrombolysis Using Recombinant Tissue Plasminogen Activator in Acute Stroke Patients with Unknown Onset Time

Aoki, J., Kimura, K., Shibazaki, K., & Sakamoto, Y. (2013) · Cerebrovascular Diseases Extra · doi:10.1159/000348552 · Cited by 1,929 · see citing works

Mechanisms of Thrombus Formation

Furie, B., & Furie, B. C. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0801082 · Cited by 1,926 · see citing works

Mechanisms, challenges and opportunities in stroke

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Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

Mittelbrunn, M., Gutiérrez‐Vázquez, C., Villarroya‐Beltri, C., González, S., Sánchez‐Cabo, F., González, M. A., Bernad, A., & Sánchez‐Madrid, F. (2011) · Nature Communications · doi:10.1038/ncomms1285 · Cited by 1,768 · see citing works

Plasticity in gray and white: neuroimaging changes in brain structure during learning

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

Lashuel, H. A., Overk, C., Oueslati, A., & Masliah, E. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3406 · Cited by 1,623 · see citing works

Physiological and pathological roles for microRNAs in the immune system

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Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials

Kearney, P. M., Baigent, C., Godwin, J., Halls, H. J., Emberson, J., & Patrono, C. (2006) · BMJ · doi:10.1136/bmj.332.7553.1302 · Cited by 1,441 · see citing works

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R. C., Ju, S., Mu, J., Zhang, L., Steinman, L., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.164 · Cited by 1,356 · see citing works

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

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VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain

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Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

Rani, S., Ryan, A. E., Griffin, M. D., & Ritter, T. (2015) · Molecular Therapy · doi:10.1038/mt.2015.44 · Cited by 1,233 · see citing works

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

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Molecular Characterization of Dendritic Cell-Derived Exosomes

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Exosomes: secreted vesicles and intercellular communications

Théry, C. (2011) · F1000 Biology Reports · doi:10.3410/b3-15 · Cited by 989 · see citing works

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

Xin, H., Li, Y., Cui, Y., Yang, J. J., Zhang, Z. G., & Chopp, M. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.152 · Cited by 985 · see citing works

Stroke-induced Immunodeficiency Promotes Spontaneous Bacterial Infections and Is Mediated by Sympathetic Activation Reversal by Poststroke T Helper Cell Type 1–like Immunostimulation

Prass, K., Meisel, C., Höflich, C., Braun, J., Halle, E., Wolf, T., Ruscher, K., Victorov, I. V., Priller, J., Dirnagl, U., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021098 · Cited by 927 · see citing works

Intra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical Trial

Jo, C. H., Lee, Y. G., Shin, W. H., Kim, H., Chai, J. W., Jeong, E. C., Kim, J. E., Shim, H., Shin, J. S., Shin, I. S., et al. (2014) · Stem Cells · doi:10.1002/stem.1634 · Cited by 916 · see citing works

Mesenchymal Stem Cells

Ding, D., Shyu, W., & Lin, S. (2011) · Cell Transplantation · doi:10.3727/096368910x · Cited by 915 · see citing works

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

Xin, H., Li, Y., Buller, B., Katakowski, M., Zhang, Y., Wang, X., Shang, X., Zhang, Z. G., & Chopp, M. (2012) · Stem Cells · doi:10.1002/stem.1129 · Cited by 897 · see citing works

Risk factors and burden of osteoarthritis

Palazzo, C., Nguyen, C., Lefèvre‐Colau, M., Rannou, F., & Poiraudeau, S. (2016) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2016.01.006 · Cited by 888 · see citing works

A Neurovascular Niche for Neurogenesis after Stroke

Ohab, J. J., Fleming, S., Blesch, A., & Carmichael, S. T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4323-06.2006 · Cited by 878 · see citing works

Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling

Young, K. M., Psachoulia, K., Tripathi, R. B., Dunn, S.-J., Cossell, L., Attwell, D., Tohyama, K., & Richardson, W. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.006 · Cited by 872 · see citing works

Rapid Secretion of Interleukin-1β by Microvesicle Shedding

Mackenzie, A. B., Wilson, H. L., Kiss‐Toth, E., Dower, S., North, R. A., & Surprenant, A. (2001) · Immunity · doi:10.1016/s1074-7613(01)00229-1 · Cited by 862 · see citing works

Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities

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Proteomic profiling of exosomes: Current perspectives

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Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery

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Factors Influencing the Decline in Stroke Mortality: A Statement From the American Heart Association/American Stroke Association

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Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury

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Use of Nonsteroidal Antiinflammatory Drugs: An Update for Clinicians: A Scientific Statement From the American Heart Association

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Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

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Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species

Baglio, S. R., Rooijers, K., Koppers‐Lalic, D., Verweij, F. J., Pérez-Lanzón, M., Zini, N., Naaijkens, B. A., Perut, F., Niessen, H. W. M., Baldini, N., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0116-z · Cited by 766 · see citing works

Secreted microRNAs: a new form of intercellular communication

Chen, X., Liang, H., Zhang, J., Zen, K., & Zhang, C. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.12.001 · Cited by 761 · see citing works

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

Xin, H., Li, Y., Liu, Z., Wang, X., Shang, X., Cui, Y., Zhang, Z. G., & Chopp, M. (2013) · Stem Cells · doi:10.1002/stem.1409 · Cited by 724 · see citing works

Pathology of Parkinson’s disease

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Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

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Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration

Zhang, S., Chu, W. C., Lai, R. C., Lim, S. K., Hui, J. H. P., & Toh, W. S. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.06.022 · Cited by 673 · see citing works

Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro

Zhou, Y., Xu, H., Xu, W., Wang, B., Wu, H., Tao, Y., Zhang, B., Wang, M., Mao, F., Yan, Y., et al. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt194 · Cited by 647 · see citing works

Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo

Bhatnagar, S., Shinagawa, K., Castellino, F., & Schorey, J. S. (2007) · Blood · doi:10.1182/blood-2007-03-079152 · Cited by 634 · see citing works

β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

Masliah, E., Rockenstein, E., Veinbergs, I., Sagara, Y., Mallory, M., Hashimoto, M., & Mucke, L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211412398 · Cited by 607 · see citing works

Astrocyte-Derived ATP Induces Vesicle Shedding and IL-1β Release from Microglia

Bianco, F., Pravettoni, E., Colombo, A., Schenk, U., Möller, T., Matteoli, M., & Verderio, C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7268 · Cited by 596 · see citing works

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

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An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage

Sherer, T., Betarbet, R. S., Stout, A. K., Lund, S. A., Baptista, M. J., Panov, A. V., Cookson, M., & Greenamyre, J. T. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07006.2002 · Cited by 581 · see citing works

Synergistic Interactions between Aβ, Tau, and α-Synuclein: Acceleration of Neuropathology and Cognitive Decline

Clinton, L. K., Blurton-Jones, M., Myczek, K., Trojanowski, J. Q., & LaFerla, F. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0490-10.2010 · Cited by 576 · see citing works

Exosomes: immune properties and potential clinical implementations

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Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment

Pagonabarraga, J., Kulisevsky, J., Strafella, A. P., & Krack, P. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00019-8 · Cited by 556 · see citing works

Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry

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Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

Gui, Y., Liu, H., Zhang, L., Lv, W., & Hu, X. (2015) · Oncotarget · doi:10.18632/oncotarget.6158 · Cited by 552 · see citing works

Acid sphingomyelinase activity triggers microparticle release from glial cells

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Exosomes for drug delivery—A novel application for the mesenchymal stem cell

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Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy

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The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

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Disease‐specific patterns of locus coeruleus cell loss

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Therapeutic Applications of Extracellular Vesicles: Clinical Promise and Open Questions

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MicroRNA‐140 is expressed in differentiated human articular chondrocytes and modulates interleukin‐1 responses

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Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat.

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Human Tumor-Released Microvesicles Promote the Differentiation of Myeloid Cells with Transforming Growth Factor-β–Mediated Suppressive Activity on T Lymphocytes

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Tumour-released exosomes and their implications in cancer immunity

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Environmental risk factors and Parkinson's disease: a metaanalysis.

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Neural Stem Cells and Stroke

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Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?

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Skeletal Muscle-Released Extracellular Vesicles: State of the Art

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Mesenchymal Stromal Cells for Aging Cartilage Regeneration: A Review

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P5397Mesenchymal stem cells derived from bone marrow promotes cardiomyocytes survival under hypoxia through exosomal miR-210

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Identification of Cell-Specific Soluble Mediators and Cellular Targets During Cell Therapy for the Treatment of Heart Failure

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Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice

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Enhanced Cell Therapy for Ischemic Heart Disease

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Stem Cell Therapy

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