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MiR-126 Contributes to Human Umbilical Cord Blood Cell-Induced Neurorestorative Effects After Stroke in Type-2 Diabetic Mice

Chen, Jieli, Ning, Ruizhuo, Zacharek, Alex, Cui, Chengcheng, Cui, Xu, Yan, Tao, Venkat, Poornima, Zhang, Yi, Chopp, Michael·2016·Stem Cells
DOI 10.1002/stem.2193PMC PMC4713352
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Abstract

Diabetes mellitus (DM) is a high risk factor for stroke and leads to more severe vascular and white-matter injury than stroke in non-DM. We tested the neurorestorative effects of delayed human umbilical cord blood cell (HUCBC) treatment of stroke in type-2 diabetes (T2DM). db/db-T2DM and db/+-non-DM mice were subjected to distal middle cerebral artery occlusion (dMCAo) and were treated 3 days after dMCAo with: (a) non-DM + Phosphate buffered saline (PBS); (b) T2DM + PBS; (c) T2DM + naïve-HUCBC; (d) T2DM + miR-126−/−HUCBC. Functional evaluation, vascular and white-matter changes, neuroinflammation, and miR-126 effects were measured in vivo and in vitro. T2DM mice exhibited significantly decreased serum and brain tissue miR-126 expression compared with non-DM mice. T2DM+HUCBC mice exhibited increased miR-126 expression, increased tight junction protein expression, axon/myelin, vascular density, and M2-macrophage polarization. However, decreased blood-brain barrier leakage, brain hemorrhage, and miR-126 targeted gene vascular cell adhesion molecule-1 and monocyte chemotactic protein 1 expression in the ischemic brain as well as improved functional outcome were present in HUCBC-treated T2DM mice compared with control T2DM mice. MiR-126−/−HUCBC-treatment abolished the benefits of naïve-HUCBC-treatment in T2DM stroke mice. In vitro, knock-in of miR-126 in primary cultured brain endothelial cells (BECs) or treatment of BECs with naïve-HUCBCs significantly increased capillary-like tube formation, and increased axonal outgrowth in primary cultured cortical neurons; whereas treatment of BECs or cortical neurons with miR-126−/−HUCBC attenuated HUCBC-treatment-induced capillary tube formation and axonal outgrowth. Our data suggest delayed HUCBC-treatment of stroke increases vascular/white-matter remodeling and anti-inflammatory effects; MiR-126 may contribute to HUCBC-induced neurorestorative effects in T2DM mice.

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Metadata

Authors
Chen, J., Ning, R., Zacharek, A., Cui, C., Cui, X., Yan, T., Venkat, P., Zhang, Y., & Chopp, M.
Affiliations
Department of Neurology, Henry Ford Hospital, Detroit, Michigan, USA
Venue
Stem Cells
Publisher
Oxford University Press (OUP)
Published
2016-01-01
Volume
34
Issue
1
Pages
102-113
ISSN
  • 1066-5099
  • 1549-4918
DOI
10.1002/stem.2193
PMC
PMC4713352
Cited by
58
References
5
Language
en
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Funders
  • National Institute on Aging (R01 AG031811, R01 AG 037506)
  • National Institute of Neurological Disorders and Stroke (R01 NS083078-01A1, R01 NS092917-01, R41 NS080329-01A1)
  • American Heart Association (14GRNT20460026, 12SDG9300009)

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