Endogenous Wnt Signaling Maintains Neural Progenitor Cell Potency
Open accessAbstract
Wnt signaling regulates neural stem cell (NSC) function and development throughout an individual's lifetime. Intriguingly, adult hippocampal progenitors (AHPs) produce several Wnts, and the intracellular machinery necessary to respond to them, creating the potential for an active autocrine-signaling loop within this stem cell niche. However, the standard luciferase-based Wnt assay failed to detect this signaling loop. This assay is inherently less temporally sensitive to activity among a population of unsynchronized proliferating cells because it relies on the rapidly degrading reporter luciferase. We circumvented this limitation using a promoter assay that employs green fluorescent protein (GFP), as a relatively long-lived reporter of canonical Wnt activity. We found that at baseline, AHPs secreted functional Wnt that self-stimulates low-level canonical Wnt signaling. Elimination baseline Wnt activity, via application of an extracellular Wnt antagonist promoted neurogenesis, based on a combination of unbiased gene expression analysis and cell-fate analysis. A detailed clonal analysis of progenitors transduced with specific intracellular antagonists of canonical signaling, either Axin or truncated cadherin (β-catenin sequestering), revealed that loss of baseline signaling depletes the population of multipotent precursors, thereby driving an increasing fraction to assume a committed cell fate (i.e., unipotent progenitors). Similarly, baseline Wnt signaling repressed differentiation of human NSCs. Although the specific Wnts produced by neural precursors vary with age and between species, their effects remain remarkably consistent. In sum, this study establishes that autonomous Wnt signaling is a conserved feature of the neurogenic niche that preserves the delicate balance between NSC maintenance and differentiation. Disclosure of potential conflicts of interest is found at the end of this article.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In FTD, two studies re-analysed published transcriptome data and discovered a role for WNT signalling in GRN-mediated FTD.
“In FTD, two studies re-analysed published transcriptome data139 to discover a role for WNT signalling in GRN-mediated FTD153,154.”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [154]
Those studies identified transcriptomic changes shared across post-mortem human brain, human neural cell lines, and mouse brain.
“Both involved extensive bioinformatic analyses of expression data from in vitro neural progenitor models and identified transcriptomic changes shared across the post-mortem human brain, human neural cell lines and the mouse brain.”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [154]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572 · see citing works
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880 · see citing works
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139 · see citing works
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426 · see citing works
Self-citationWnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257 · see citing works
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159 · see citing works
Exercise enhances learning and hippocampal neurogenesis in aged mice
van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078 · see citing works
Wnt signalling regulates adult hippocampal neurogenesis
Lie, D. C., Colamarino, S. A., Song, H., Désiré, L., Mira, H., Consiglio, A., Lein, E. S., Jessberger, S., Lansford, H., Dearie, A. R., et al. (2005) · Nature · doi:10.1038/nature04108 · Cited by 1,510 · see citing works
Wetering, M. L. V. D., Cavallo, R. A., Dooijes, D., van Beest, M., van Es, J. V., Loureiro, J., Ypma, A., Hursh, D., Jones, T. L., Bejsovec, A., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81925-x · Cited by 1,347 · see citing works
SOX2 Functions to Maintain Neural Progenitor Identity
Graham, V., Khudyakov, J. I., Ellis, P., & Pevny, L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00497-5 · Cited by 1,344 · see citing works
Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
Sanai, N., Tramontin, A. D., Quiñones‐Hinojosa, A., Barbaro, N. M., Gupta, N. M., Kunwar, S., Lawton, M. T., McDermott, M. W., Parsa, A. T., García‐Verdugo, J. M., et al. (2004) · Nature · doi:10.1038/nature02301 · Cited by 1,315 · see citing works
Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context
Mikels, A. J., & Nusse, R. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040115 · Cited by 1,244 · see citing works
Adult hippocampal neurogenesis in depression
Sahay, A., & Hen, R. (2007) · Nature Neuroscience · doi:10.1038/nn1969 · Cited by 1,206 · see citing works
A unified hypothesis on the lineage of neural stem cells
Álvarez-Buylla, A., García‐Verdugo, J. M., & Tramontin, A. D. (2001) · Nature reviews. Neuroscience · doi:10.1038/35067582 · Cited by 995 · see citing works
Garcia, A. D. R., Doan, N., Imura, T., Bush, T. G., & Sofroniew, M. V. (2004) · Nature Neuroscience · doi:10.1038/nn1340 · Cited by 990 · see citing works
Palmer, T. D., Markakis, E. A., Willhoite, A. R., Safar, F., & Gage, F. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08487.1999 · Cited by 909 · see citing works
Self-citationWnt/β-catenin signaling in cancer stemness and malignant behavior
Fodde, R., & Brabletz, T. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.007 · Cited by 786 · see citing works
A BDNF autocrine loop in adult sensory neurons prevents cell death
Acheson, A., Conover, J. C., Fandl, J. P., DeChiara, T. M., Russell, M., Thadani, A., Squinto, S. P., Yancopoulos, G. D., & Lindsay, R. M. (1995) · Nature · doi:10.1038/374450a0 · Cited by 765 · see citing works
A new secreted protein that binds to Wnt proteins and inhibits their activites
Hsieh, J.-C., Kodjabachian, L., Rebbert, M. L., Rattner, A., Smallwood, P. M., Samos, C. H., Nusse, R., Dawid, I. B., & Nathans, J. (1999) · Nature · doi:10.1038/18899 · Cited by 750 · see citing works
Making a tumour's bed: glioblastoma stem cells and the vascular niche
Gilbertson, R. J., & Rich, J. N. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2246 · Cited by 716 · see citing works
A mitogen gradient of dorsal midline Wnts organizes growth in the CNS
Megason, S. G., & McMahon, A. P. (2002) · Development · doi:10.1242/dev.129.9.2087 · Cited by 681 · see citing works
Schmidt, H. D., & Duman, R. S. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee2aa8 · Cited by 649 · see citing works
A local Wnt-3a signal is required for development of the mammalian hippocampus
Lee, S. M. K., Tole, S., Grove, E. A., & McMahon, A. P. (2000) · Development · doi:10.1242/dev.127.3.457 · Cited by 636 · see citing works
A niche for adult neural stem cells
Doetsch, F. K. (2003) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2003.08.012 · Cited by 619 · see citing works
Enhancement of Hippocampal Neurogenesis by Lithium
Chen, G., Rajkowska, G., Du, F., Seraji‐Bozorgzad, N., & Manji, H. K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751729.x · Cited by 601 · see citing works
Wnt3a Plays a Major Role in the Segmentation Clock Controlling Somitogenesis
Aulehla, A., Wehrle, C., Brand‐Saberi, B., Kemler, R., Gossler, A., Kanzler, B., & Herrmann, B. G. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00055-8 · Cited by 593 · see citing works
A new method for the rapid and long term growth of human neural precursor cells
Svendsen, C. N., Borg, M. G. T., Armstrong, R. J. E., Rosser, A., Chandran, S., Ostenfeld, T., & Caldwell, M. A. (1998) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(98)00126-5 · Cited by 571 · see citing works
Attenuation of green fluorescent protein half-life in mammalian cells
Corish, P., & Tyler‐Smith, C. (1999) · Protein Engineering Design and Selection · doi:10.1093/protein/12.12.1035 · Cited by 561 · see citing works
Fleming, H. E., Janzen, V., Celso, C. L., Guo, J., Leahy, K. M., Kronenberg, H. M., & Scadden, D. T. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.01.003 · Cited by 500 · see citing works
Filippov, V., Kronenberg, G., Pivneva, T. A., Reuter, K., Steiner, B., Wang, L.-P., Yamaguchi, M., Kettenmann, H., & Kempermann, G. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00060-5 · Cited by 483 · see citing works
Iosif, R. E., Ekdahl, C. T., Ahlenius, H., Pronk, C. J., Bonde, S., Kokaia, Z., Jacobsen, S. E. W., & Lindvall, O. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2723-06.2006 · Cited by 462 · see citing works
Progenitor cells from human brain after death
Palmer, T. D., Schwartz, P. H., Taupin, P., Kaspar, B. K., Stein, S. A., & Gage, F. H. (2001) · Nature · doi:10.1038/35075141 · Cited by 457 · see citing works
Self-citationβ-catenin is critical for dendritic morphogenesis
Yu, X., & Malenka, R. C. (2003) · Nature Neuroscience · doi:10.1038/nn1132 · Cited by 454 · see citing works
Transformation by Wnt family proteins correlates with regulation of beta-catenin.
Shimizu, H., Julius, M. A., Giarrè, M., Zheng, Z., Brown, A. M. C., & Kitajewski, J. (1997) · PubMed · Cited by 412 · see citing works
Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1
Galcerán, J., Miyashita-Lin, E. M., Devaney, E. J., Rubenstein, J. L. R., & Grosschedl, R. (2000) · Development · doi:10.1242/dev.127.3.469 · Cited by 399 · see citing works
Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
Castelo‐Branco, G., Wagner, J., Rodríguez, F. J., Kele, J., Sousa, K. M., Rawal, N., Pasolli, H. A., Fuchs, E. V., Kitajewski, J., & Arenas, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1534900100 · Cited by 367 · see citing works
Expression Profiling and Functional Analysis of Wnt Signaling Mechanisms in Mesenchymal Stem Cells
Etheridge, S. L., Spencer, G. J., Heath, D. J., & Genever, P. G. (2004) · Stem Cells · doi:10.1634/stemcells.22-5-849 · Cited by 346 · see citing works
Regulation of Wnt Signaling by Sox Proteins
Zorn, A. M., Barish, G. D., Williams, B. O., Lavender, P., Klymkowsky, M. W., & VARMUS, H. E. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80200-2 · Cited by 342 · see citing works
Aubert, J., Dunstan, H., Chambers, I., & Smith, A. G. (2002) · Nature Biotechnology · doi:10.1038/nbt763 · Cited by 325 · see citing works
An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells
Bafico, A., Liu, G., Goldin, L., Harris, V., & Aaronson, S. A. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.032 · Cited by 321 · see citing works
Cytoskeletal reorganization by soluble Wnt‐3a protein signalling
Shibamoto, Higano, K., Takada, R., Ito, F., Takeichi, M., & Takada, S. (1998) · Genes to Cells · doi:10.1046/j.1365-2443.1998.00221.x · Cited by 251 · see citing works
Adachi, K., Mirzadeh, Z., Sakaguchi, M., Yamashita, T., Nikolcheva, T., Gotoh, Y., Peltz, G., Gong, L., Kawase, T., Álvarez-Buylla, A., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0177 · Cited by 243 · see citing works
Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways
Kelly, G. M., Greenstein, P., Erezyilmaz, D. F., & Moon, R. T. (1995) · Development · doi:10.1242/dev.121.6.1787 · Cited by 231 · see citing works
Schlange, T., Matsuda, Y., Lienhard, S., Huber, A., & Hynes, N. E. (2007) · Breast Cancer Research · doi:10.1186/bcr1769 · Cited by 229 · see citing works
β-Catenin signaling is required for neural differentiation of embryonic stem cells
Otero, J. J., Fu, W., Kan, L., Cuadra, A. E., & Kessler, J. A. (2004) · Development · doi:10.1242/dev.01218 · Cited by 203 · see citing works
Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation
Wexler, E., Geschwind, D. H., & Palmer, T. D. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002093 · Cited by 191 · see citing works
Self-citationRole of wnts in prostate cancer bone metastases
Hall, C. L., Kang, S., MacDougald, O. A., & Keller, E. T. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20735 · Cited by 176 · see citing works
Sox1 acts through multiple independent pathways to promote neurogenesis
Kan, L., Israsena, N., Zhang, Z., Hu, M., Zhao, L.-R., Jalali, A., Sahni, V., & Kessler, J. A. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.02.005 · Cited by 171 · see citing works
Redundant expression of canonical Wnt ligands in human breast cancer cell lines
Benhaj, K., Akçalı, K. C., & Öztürk, M. (2006) · Oncology Reports · doi:10.3892/or.15.3.701 · Cited by 157 · see citing works
Cellular Interactions in the Stem Cell Niche
Wurmser, A. E., Palmer, T. D., & Gage, F. H. (2004) · Science · doi:10.1126/science.1099344 · Cited by 147 · see citing works
Self-citationImmature Neurons From CNS Stem Cells Proliferate in Response to Platelet-Derived Growth Factor
Erlandsson, A., Enarsson, M., & Forsberg‐Nilsson, K. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03483.2001 · Cited by 140 · see citing works
The Soluble Wnt Receptor Frizzled8CRD-hFc Inhibits the Growth of Teratocarcinomas In vivo
DeAlmeida, V. I., Li, M., Ernst, J. A., Koeppen, H., Polakis, P. G., & Rubinfeld, B. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0266 · Cited by 139 · see citing works
Members of the Wnt, Fz, and Frp gene families expressed in postnatal mouse cerebral cortex
Shimogori, T., VanSant, J., Paik, E. K., & Grove, E. A. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20135 · Cited by 137 · see citing works
Brain Area-Specific Effect of TGF-β Signaling on Wnt-Dependent Neural Stem Cell Expansion
Falk, S., Wurdak, H., Ittner, L. M., Ille, F., Sumara, G., Schmid, M.-T., Draganova, K., Lang, K. S., Paratore, C., Levéen, P., et al. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.03.006 · Cited by 136 · see citing works
Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma
Chim, C. S., Pang, R., Fung, T. K., Choi, C.-L., & Liang, R. H. S. (2007) · Leukemia · doi:10.1038/sj.leu.2404939 · Cited by 131 · see citing works
The making of Wnt: new insights into Wnt maturation, sorting and secretion
Coudreuse, D. Y. M., & Korswagen, H. C. (2006) · Development · doi:10.1242/dev.02699 · Cited by 129 · see citing works
No association between the WNT2 gene and autistic disorder
McCoy, P. A., Shao, Y., Wolpert, C. M., Donnelly, S. L., Ashley‐Koch, A. E., Abel, H., Ravan, S. A., Abramson, R. K., Wright, H. H., DeLong, G. R., et al. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.10182 · Cited by 109 · see citing works
Sumanas, S., Strege, P. R., Heasman, J., & Ekker, S. C. (2000) · Development · doi:10.1242/dev.127.9.1981 · Cited by 105 · see citing works
Yu, J. M., Kim, J. H., Song, G. S., & Jung, J. S. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-9113-3 · Cited by 98 · see citing works
In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133
Barraud, P., Stott, S., Møllgård, K., Parmar, M., & Björklund, A. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21116 · Cited by 93 · see citing works
Hirsch, C., Campano, L. M., Wöhrle, S., & Hecht, A. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.11.002 · Cited by 90 · see citing works
Mechanism of extracellular domain-deleted dominant negative cadherins
Nieman, M. T., Kim, J., Johnson, K. R., & Wheelock, M. J. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.10.1621 · Cited by 83 · see citing works
Verani, R., Cappuccio, I., Spinsanti, P., Gradini, R., Caruso, A., Magnotti, M. C., Motolese, M., Nicoletti, F., & Melchiorri, D. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04207.x · Cited by 82 · see citing works
Davidson, K. C., Jamshidi, P., Daly, R., Hearn, M. T. W., Pera, M. F., & Dottori, M. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.07.013 · Cited by 68 · see citing works
Adult Neurogenesis and the Vascular Nietzsche
Palmer, T. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00738-9 · Cited by 66 · see citing works
Self-citationDual-Function Reporter Protein for Analysis of Gene Expression in Living Cells
Day, R. N., Kawecki, M., & Berry, D. (1998) · BioTechniques · doi:10.2144/98255bt02 · Cited by 65 · see citing works
Suda, T., & Arai, F. (2008) · Cell · doi:10.1016/j.cell.2008.02.017 · Cited by 62 · see citing works
Isolation and characterization of neural precursor cells from the Sox1–GFP reporter mouse
Barraud, P., Thompson, L. H., Kirik, D., Björklund, A., & Parmar, M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04352.x · Cited by 59 · see citing works
Activity of Wnt-1 as a transmembrane protein.Preprint
Parkin, N. T., Kitajewski, J., & VARMUS, H. E. (1993) · Genes & Development · doi:10.1101/gad.7.11.2181 · Cited by 46 · see citing works
Colombo, E. V., Giannelli, S. G., Galli, R., Tagliafico, E., Foroni, C., Tenedini, E., Ferrari, S., Ferrari, S., Corte, G., Vescovi, A. L., et al. (2005) · Stem Cells · doi:10.1634/stemcells.2005-0313 · Cited by 42 · see citing works
Noles, S. R., & Chenn, A. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.04.012 · Cited by 35 · see citing works
Chen, G., Yablonka‐Reuveni, Z., Quinn, L. S., & Birnbaum, R. S. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041600320 · Cited by 34 · see citing works
LIF Is an Autocrine Factor for Sympathetic Neurons
Cheng, J.-G., & Patterson, P. H. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1997.0635 · Cited by 31 · see citing works
Yin, Z., Zhang, H., Wang, W., Hua, X., Hu, Y., Zhang, S., & Li, G.-W. (2007) · Neurological Research · doi:10.1179/016164107x223539 · Cited by 19 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Regulation and function of adult neurogenesis: from genes to cognition.
Aimone, J. B., Li, Y., Lee, S. W., Clemenson, G. D., Deng, W., & Gage, F. H. (2014) · Physiological Reviews · doi:10.1152/physrev.00004.2014 · Cited by 635 · see citing works
Emerging roles of Wnts in the adult nervous system
Inestrosa, N. C., & Arenas, E. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2755 · Cited by 611 · see citing works
Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders
Parikshak, N. N., Gandal, M. J., & Geschwind, D. H. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3934 · Cited by 430 · see citing works
Self-citationGSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder
Valvezan, A. J., & Klein, P. S. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00001 · Cited by 384 · see citing works
Adult neurogenesis and brain regeneration in zebrafish
Kızıl, Ç., Kaslin, J., Kroehne, V., & Brand, M. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20918 · Cited by 346 · see citing works
Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells
Yu, D. X., Giorgio, F. P. D., Yao, J., Marchetto, M. C., Brennand, K., Wright, R., Mei, A., McHenry, L. K., Lisuk, D., Grasmick, J. M., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.01.009 · Cited by 264 · see citing works
Wnt/Catenin Signaling in Adult Stem Cell Physiology and Disease
Ring, A., Kim, Y., & Kahn, M. (2014) · Stem Cell Reviews and Reports · doi:10.1007/s12015-014-9515-2 · Cited by 240 · see citing works
Li, M., Lee, K. F., Lu, Y., Clarke, I. D., Shih, D. J. H., Eberhart, C. G., Collins, V. P., Meter, T. E. V., Picard, D. J., Zhou, L., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.10.025 · Cited by 235 · see citing works
Signaling in adult neurogenesis
Mu, Y., Lee, S. W., & Gage, F. H. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.04.010 · Cited by 217 · see citing works
RBFOX1 regulates both splicing and transcriptional networks in human neuronal development
Fogel, B. L., Wexler, E., Wahnich, A., Friedrich, T., Vijayendran, C., Gao, F., Parikshak, N., Konopka, G., & Geschwind, D. H. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds240 · Cited by 216 · see citing works
Self-citationWnt signaling in the regulation of adult hippocampal neurogenesis
Varela‐Nallar, L., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00100 · Cited by 197 · see citing works
Glial cells in adult neurogenesis
Morrens, J., Broeck, W. V. D., & Kempermann, G. (2011) · Glia · doi:10.1002/glia.21247 · Cited by 180 · see citing works
Marchetti, B., Tirolo, C., L’Episcopo, F., Caniglia, S., Testa, N., Smith, J. A., Pluchino, S., & Serapide, M. F. (2020) · Aging Cell · doi:10.1111/acel.13101 · Cited by 185 · see citing works
Wnt your brain be inflamed? Yes, it Wnt!
Marchetti, B., & Pluchino, S. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.12.001 · Cited by 167 · see citing works
Glycogen Synthase Kinase 3 Inhibition Promotes Adult Hippocampal Neurogenesis in Vitro and in Vivo
Morales-Garcia, J. A., Luna‐Medina, R., Alonso‐Gil, S., Sanz-SanCristóbal, M., Palomo, V., Gil, C., Santos, Á., Martı́nez, A., & Pérez‐Castillo, A. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300110c · Cited by 162 · see citing works
Wnt signalling in neuronal differentiation and development
Inestrosa, N. C., & Varela‐Nallar, L. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1996-4 · Cited by 162 · see citing works
Canonical and noncanonical Wnt signaling in neural stem/progenitor cells
Bengoa‐Vergniory, N., & Kypta, R. M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2028-6 · Cited by 161 · see citing works
Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease
Arredondo, S. B., Valenzuela-Bezanilla, D., Mardones, M. D., & Varela‐Nallar, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00860 · Cited by 153 · see citing works
Christie, K. J., & Turnley, A. M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00070 · Cited by 146 · see citing works
The Wnt /β-catenin signaling pathway in the adult neurogenesis
Zhang, L., Yang, X., Yang, S., & Zhang, J. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.7483.x · Cited by 134 · see citing works
The Role of Astrocytes in the Neurorepair Process
Chiareli, R. A., Carvalho, G. A., Marques, B. L., Mota, L. S., Oliveira‐Lima, O. C., Gomes, R. M., Birbrair, A., Gomez, R. S., Simão, F., Klempin, F., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.665795 · Cited by 126 · see citing works
Yu, M. S., Qin, K. H., Fan, J., Zhao, G., Zhao, P., Zeng, W., Chen, C., Wang, A., Wang, Y., Zhong, J., et al. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.04.042 · Cited by 118 · see citing works
Neurodevelopmental Perspectives on Wnt Signaling in Psychiatry
Mulligan, K. A., & Cheyette, B. N. R. (2016) · Complex Psychiatry · doi:10.1159/000453266 · Cited by 95 · see citing works
Neural Stem Cell of the Hippocampus
Rolando, C., & Taylor, V. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00007-x · Cited by 90 · see citing works
Pilar-Cuéllar, F., Vidal, R., Díaz, Á., Castro, E., dos Anjos, S., Pascual-Brazo, J., Linge, R., Vargas, V., Blanco, H., Martínez-Villayandre, B., et al. (2013) · Journal of Neural Transplantation and Plasticity · doi:10.1155/2013/537265 · Cited by 93 · see citing works
Arredondo, S. B., Guerrero, F. G., Herrera-Soto, A., Jensen-Flores, J., Bustamante, D., Oñate‐Ponce, A., Henny, P., Varas‐Godoy, M., Inestrosa, N. C., & Varela‐Nallar, L. (2019) · Stem Cells · doi:10.1002/stem.3121 · Cited by 85 · see citing works
Physiological Role of β-Catenin/TCF Signaling in Neurons of the Adult Brain
Wisniewska, M. B. (2013) · Neurochemical Research · doi:10.1007/s11064-013-0980-9 · Cited by 83 · see citing works
Raitano, S., Ordovás, L., Muynck, L. D., Guo, W., Espuny-Camacho, I., Geraerts, M., Khurana, S., Vanuytsel, K., Tóth, B. I., Voets, T., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.12.001 · Cited by 82 · see citing works
Saharan, S., Jhaveri, D. J., & Bartlett, P. F. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23199 · Cited by 79 · see citing works
Modeling the functional genomics of autism using human neurons
Konopka, G., Wexler, E., Rosen, E., Mukamel, Z., Osborn, G. E., Chen, L., Lu, D., Gao, F., Gao, K., Lowe, J. K., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.60 · Cited by 76 · see citing works
Self-citationSpatiotemporal expression patterns of Pax6 in the brain of embryonic, newborn, and adult mice
Duan, D., Fu, Y., Paxinos, G., & WATSON, C. R. R. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0397-2 · Cited by 75 · see citing works
Fujimaki, S., & Kuwabara, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102147 · Cited by 75 · see citing works
G-Protein-Coupled Receptors in Adult Neurogenesis
Doze, V. A., & Perez, D. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.004762 · Cited by 73 · see citing works
Simvastatin Promotes Adult Hippocampal Neurogenesis by Enhancing Wnt/β-Catenin Signaling
Robin, N. C., Agoston, Z., Biechele, T. L., James, R. G., Berndt, J. D., & Moon, R. T. (2013) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.11.002 · Cited by 73 · see citing works
Dissecting the Genetic and Etiological Causes of Primary Microcephaly
Jean, F., Stuart, A., & Tarailo‐Graovac, M. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.570830 · Cited by 71 · see citing works
Probing Embryonic Stem Cell Autocrine and Paracrine Signaling Using Microfluidics
Joel Voldman, B., & Przybyla, L. (2012) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 71 · see citing works
In vitro and in vivo neurogenic potential of mesenchymal stem cells isolated from different sources
Taran, R., Mamidi, M. K., Singh, G., Dutta, S., Parhar, I. S., John, J. P., Bhonde, R. R., Pal, R., & Das, A. K. (2014) · Journal of Biosciences · doi:10.1007/s12038-013-9409-5 · Cited by 71 · see citing works
Frizzled-1 receptor regulates adult hippocampal neurogenesis
Mardones, M. D., Andaur, G. A., Varas‐Godoy, M., Henriquez, J. F., Salech, F., Behrens, M. I., Couve, A., Inestrosa, N. C., & Varela‐Nallar, L. (2016) · Molecular Brain · doi:10.1186/s13041-016-0209-3 · Cited by 68 · see citing works
Kahlert, U. D., Suwala, A. K., Koch, K., Natsumeda, M., Orr, B. A., Hayashi, M., Maciaczyk, J., & Eberhart, C. G. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000227 · Cited by 68 · see citing works
Knosp, W. M., Knox, S. M., Lombaert, I. M. A., Haddox, C. L., Patel, V. N., & Hoffman, M. P. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.01.023 · Cited by 67 · see citing works
Haack, F., Lemcke, H., Ewald, R., Rharass, T., & Uhrmacher, A. M. (2015) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1004106 · Cited by 66 · see citing works
Bengoa‐Vergniory, N., Gorroño‐Etxebarria, I., González-Salazar, I., & Kypta, R. M. (2014) · Stem Cells · doi:10.1002/stem.1807 · Cited by 65 · see citing works
Induction of the Wnt Antagonist Dickkopf-1 Is Involved in Stress-Induced Hippocampal Damage
Matrisciano, F., Busceti, C. L., Bucci, D., Orlando, R., Caruso, A., Molinaro, G., Cappuccio, I., Riozzi, B., Gradini, R., Motolese, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016447 · Cited by 64 · see citing works
Control of Adult Neurogenesis by Short-Range Morphogenic-Signaling MoleculesPreprint
Choe, Y., Pleasure, S. J., & Mira, H. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018887 · Cited by 62 · see citing works
Gsx1 promotes locomotor functional recovery after spinal cord injury
Patel, M., Li, Y., Anderson, J., Castro-Pedrido, S., Skinner, R., Lei, S., Finkel, Z., Rodriguez, B., Esteban, F., Lee, K., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.04.027 · Cited by 60 · see citing works
Andrographolide Stimulates Neurogenesis in the Adult Hippocampus
Varela‐Nallar, L., Arredondo, S. B., Tapia‐Rojas, C., Hancke, J. L., & Inestrosa, N. C. (2015) · Neural Plasticity · doi:10.1155/2015/935403 · Cited by 61 · see citing works
Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway
Nakano, I., Joshi, K., Visnyei, K., Hu, B., Watanabe, M., Lam, D., Wexler, E., Saigusa, K., Nakamura, Y., Laks, D. R., et al. (2011) · Neuro-Oncology · doi:10.1093/neuonc/nor023 · Cited by 59 · see citing works
Self-citationGeneration of Cortical Brain Organoid with Vascularization by Assembling with Vascular Spheroid
Kook, M. G., Lee, S., Shin, N., Kong, D., Kim, D., Kim, M., Kang, H. K., Choi, S. W., & Kang, K. (2022) · International Journal of Stem Cells · doi:10.15283/ijsc21157 · Cited by 59 · see citing works
Molecular Mechanism of Adult Neurogenesis and its Association with Human Brain Diseases
Liu, H., & Song, N. (2016) · Journal of Central Nervous System Disease · doi:10.4137/jcnsd.s32204 · Cited by 59 · see citing works
Concise Review: Self-Renewal in the Central Nervous System: Neural Stem Cells from Embryo to Adult
Filippis, L. D., & Binda, E. (2012) · Stem Cells Translational Medicine · doi:10.5966/sctm.2011-0045 · Cited by 57 · see citing works
Wexler, E. M., Rosen, E., Lu, D., Osborn, G. E., Martin, E., Raybould, H., & Geschwind, D. H. (2011) · Science Signaling · doi:10.1126/scisignal.2002282 · Cited by 56 · see citing works
Self-citationDistinct Roles for Wnt-4 and Wnt-11 During Retinoic Acid-Induced Neuronal Differentiation
Elizalde, C., Campa, V. M., Caro, M., Schlangen, K., Aransay, A. M., Vivanco, M. D., & Kypta, R. M. (2010) · Stem Cells · doi:10.1002/stem.562 · Cited by 54 · see citing works
The Role of MicroRNAs in Neural Stem Cells and Neurogenesis
Ji, F., Lv, X., & Jiao, J. (2013) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2012.12.008 · Cited by 52 · see citing works
Armenteros, T., Andreu, Z., Hortigüela, R., Lie, D. C., & Mira, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-27581-0 · Cited by 49 · see citing works
Schizophrenia and neurogenesis: A stem cell approach.
Iannitelli, A., Quartini, A., Tirassa, P., & Bersani, G. (2017) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.06.010 · Cited by 42 · see citing works
Squillaro, T., Galano, G., Rosa, R. D., Peluso, G., & Galderisi, U. (2018) · Stem Cells · doi:10.1002/stem.2836 · Cited by 48 · see citing works
Wnt/beta-catenin signalling is dispensable for adult neural stem cell homeostasis and activation
Austin, S. H. L., Gabarró‐Solanas, R., Rigo, P., Păun, O., Harris, L., Guillemot, F., & Urbán, N. (2021) · Development · doi:10.1242/dev.199629 · Cited by 46 · see citing works
Daniel, P. M., Filiz, G., Brown, D. V., Christie, M., Waring, P., Zhang, Y., Haynes, J. M., Pouton, C. W., Flanagan, D. J., Vincan, E., et al. (2018) · Neuro-Oncology · doi:10.1093/neuonc/noy068 · Cited by 42 · see citing works
Imura, T., Wang, X., Noda, T., Sofroniew, M. V., & Fushiki, S. (2010) · Stem Cells · doi:10.1002/stem.524 · Cited by 42 · see citing works
Visual Activity Regulates Neural Progenitor Cells in Developing Xenopus CNS through Musashi1
Sharma, P., & Cline, H. T. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.028 · Cited by 40 · see citing works
Gómez‐Oliva, R., Geribaldi‐Doldán, N., Domínguez‐García, S., Carrascal, L., Verástegui, C., Nunez‐Abades, P., & Castro, C. (2020) · Aging · doi:10.18632/aging.103510 · Cited by 39 · see citing works
Matsuura, T., Moore, S. R., & Hong, C. I. (2017) · Journal of Biological Rhythms · doi:10.1177/0748730417745913 · Cited by 39 · see citing works
Zwamborn, R. A. J., Snijders, C., An, N., Thomson, A. C., Rutten, B. P. F., & de Nijs, L. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.04.005 · Cited by 39 · see citing works
Fischer, T. H., Faus-Keßler, T., Welzl, G., Simeone, A., Wurst, W., & Prakash, N. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.12.017 · Cited by 38 · see citing works
Glioma stem cell signaling: therapeutic opportunities and challenges
Dietrich, J., Diamond, E. L., & Kesari, S. (2010) · Expert Review of Anticancer Therapy · doi:10.1586/era.09.190 · Cited by 36 · see citing works
Ephrin‐A3 Suppresses Wnt Signaling to Control Retinal Stem Cell Potency
Fang, Y., Cho, K., Tchedre, K. T., Lee, S. W., Guo, C., Kinouchi, H., Fried, S. I., Sun, X., & Chen, D. F. (2012) · Stem Cells · doi:10.1002/stem.1283 · Cited by 37 · see citing works
Knotek, T., Janečková, L., Kriška, J., Kořínek, V., & Anděrová, M. (2020) · Genes · doi:10.3390/genes11070804 · Cited by 35 · see citing works
Screening, Diagnosing and Prevention of Fetal Alcohol Syndrome: Is This Syndrome Treatable
Ismail, S. A., Buckley, S., Budacki, R., Jabbar, A., & Gallicano, G. I. (2010) · Developmental Neuroscience · doi:10.1159/000313339 · Cited by 35 · see citing works
Huang, G., Smith, A. L., Gray, D. H. D., Cosgrove, C., Singer, B. H., Edwards, A., Sim, S., Parent, J. M., Johnsen, A. K., Mott, R., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000561 · Cited by 34 · see citing works
Luo, J., Yuan, F., Hong, Z., Yin, M., Zheng, H., Zhang, L., & Hu, X. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.389303 · Cited by 34 · see citing works
Selvadurai, H. J., & Mason, J. O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023012 · Cited by 34 · see citing works
Jin, X., Li, T., Zhang, L., Ma, J., Yu, L., Li, C., & Niu, L. (2017) · Medical Science Monitor · doi:10.12659/msm.902728 · Cited by 33 · see citing works
Schneider, R., Koop, B. E., Schröter, F., Cline, J. E., Ingwersen, J., Berndt, C., Hartung, H., Aktaş, O., & Prozorovski, T. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0117-0 · Cited by 31 · see citing works
Differentiation of human neural progenitor cells regulated by Wnt-3a
Hübner, R., Schmöle, A., Liedmann, A., Frech, M. J., Rolfs, A., & Luo, J. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.08.066 · Cited by 32 · see citing works
TAM receptor deficiency affects adult hippocampal neurogenesis
Ji, R., Meng, L., Li, Q., & Lu, Q. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9636-y · Cited by 32 · see citing works
The transcriptional co‐activator Yap1 promotes adult hippocampal neural stem cell activation
Fan, W., Jurado‐Arjona, J., Alanis‐Lobato, G., Péron, S., Berger, C., Andrade-Navarro, M. A., Falk, S., & Berninger, B. (2023) · The EMBO Journal · doi:10.15252/embj.2021110384 · Cited by 31 · see citing works
Diabetes and Stem Cell Function
Fujimaki, S., Wakabayashi, T., Takemasa, T., Asashima, M., & Kuwabara, T. (2015) · BioMed Research International · doi:10.1155/2015/592915 · Cited by 32 · see citing works
Bagheri‐Mohammadi, S. (2020) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1865953 · Cited by 31 · see citing works
Targeting neurogenesis ameliorates danger assessment in a mouse model of Alzheimer's disease
Shruster, A., & Offen, D. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.12.028 · Cited by 30 · see citing works
Thomas, J., Garg, M. L., & Smith, D. W. (2013) · Metabolic Brain Disease · doi:10.1007/s11011-013-9418-y · Cited by 30 · see citing works
Pérez-Domper, P., Palomo, V., Gradari, S., Gil, C., de Ceballos, M. D., Martínez, A., & Trejo, J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.12.019 · Cited by 29 · see citing works
Zrf1 is required to establish and maintain neural progenitor identityPreprint
Aloia, L., Stefano, B. D., Sessa, A., Morey, L., Santanach, A., Gutiérrez, A., Cozzuto, L., Benitah, S. A., Graf, T., Broccoli, V., et al. (2014) · Genes & Development · doi:10.1101/gad.228510.113 · Cited by 30 · see citing works
Yang, X., Bi, Y., Chen, E., & Feng, D. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23314 · Cited by 29 · see citing works
Transcriptional Regulation and Specification of Neural Stem Cells
Christie, K. J., Emery, B., Denham, M., Bujalka, H., Cate, H. S., & Turnley, A. M. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-6621-1_8 · Cited by 29 · see citing works
Yang, P., Guan, Y., Li, Y., Zhang, L., Zhang, L., & Li, L. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5377 · Cited by 29 · see citing works
Vidal, R., Garro-Martínez, E., Díaz, Á., Castro, E., Florensa-Zanuy, E., Taketo, M. M., Pazos, Á., & Pilar-Cuéllar, F. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1100-2 · Cited by 28 · see citing works
Hoyle, H. W., Stenger, C. M. L., & Przyborski, S. A. (2022) · Biomaterials and Biosystems · doi:10.1016/j.bbiosy.2022.100063 · Cited by 30 · see citing works
Slawny, N. A., & O’Shea, K. S. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.07.010 · Cited by 28 · see citing works
G-protein Coupled Receptors in Stem Cell Self-Renewal and Differentiation
Kobayashi, N. R., Hawes, S., Crook, J., & Pébay, A. (2010) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9167-9 · Cited by 28 · see citing works
Hawkins, S., Namboori, S. C., Tariq, A., Blaker, C., Flaxman, C. S., Dey, N. S., Henley, P. P., Randall, A. D., Rosa, A., Stanton, L. W., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.05.019 · Cited by 26 · see citing works
Doze, V., & Perez, D. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-394587-7.00005-1 · Cited by 24 · see citing works
Divide or Commit – Revisiting the Role of Cell Cycle Regulators in Adult Hippocampal Neurogenesis
Urbach, A., & Witte, O. W. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00055 · Cited by 26 · see citing works
Elucidating the Sources of β-Catenin Dynamics in Human Neural Progenitor Cells
Mazemondet, O., John, M., Leye, S., Rolfs, A., & Uhrmacher, A. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042792 · Cited by 25 · see citing works
Yamaguchi, K., Nagayama, S., Shimizu, E., Komura, M., Yamaguchi, R., Shibuya, T., Arai, M., Hatakeyama, S., Ikenoue, T., Ueno, M., et al. (2016) · Scientific Reports · doi:10.1038/srep26011 · Cited by 25 · see citing works
Neural Progenitor Cells and the Hypothalamus
Makrygianni, E. A., & Chrousos, G. P. (2023) · Cells · doi:10.3390/cells12141822 · Cited by 26 · see citing works
The neural stem cell secretome across neurodevelopment
Dause, T. J., Denninger, J. K., Smith, B. M., & Kirby, E. D. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114142 · Cited by 24 · see citing works
Zhang, Y., Seid, K., Obermayr, F., Just, L., & Neckel, P. H. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.03.019 · Cited by 24 · see citing works
Potential CanonicalWntPathway Activation in High-Grade Astrocytomas
Schüle, R., Dictus, C., Campos, B., Wan, F., Felsberg, J., Ahmadi, R., Centner, F.-S., Grabe, N., Reifenberger, G., Bermejo, J. L., et al. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/697313 · Cited by 23 · see citing works
Garbe, D. S., & Ring, R. H. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9841-3 · Cited by 23 · see citing works
The regulation of stem cell aging by Wnt signaling.
Fujimaki, S., Wakabayashi, T., Takemasa, T., Asashima, M., & Kuwabara, T. (2015) · PubMed · doi:10.14670/hh-11-657 · Cited by 22 · see citing works
- Authors
- Wexler, E. M., Paucer, A., Kornblum, H. I., Palmer, T. D., & Geschwind, D. H.
- Affiliations
- University of California, Los Angeles (US)
- Department of Neurosurgery, Stanford University Hospital and Clinics, Stanford, California
- Corresponding author
- Wexler, Eric M.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-02-12
- Volume
- 27
- Issue
- 5
- Pages
- 1130-1141
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- PMC
- PMC2782960
- OpenAlex
- W2103279053
- Cited by
- 174
- References
- 74
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 4 · 2023: 8 · 2022: 13 · 2021: 4 · 2020: 11 · 2019: 3 · 2018: 9 · 2017: 9 · 2016: 11 · 2015: 13 · 2014: 15 · 2013: 18 · 2012: 16
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Stem Cells (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (1r21ns045015-01)
- National Institute of Mental Health (K08 MH74362, R01MH065756, T32MH1993808, R01MH060233, K08MH074362, R37MH060233)
- National Institute of Neurological Disorders and Stroke (R21 NS045015)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt signaling, neural stem cells, autocrine signaling, neurogenesis, stem cell differentiation, Axin, β-catenin, neurogenic niche, cell fate specification, multipotent progenitors
- MeSH terms
- Animals, Cell Differentiation, Cell Line, Hippocampus, Humans, Neurons, Species Specificity, Stem Cells, Signal Transduction, Autocrine Communication, Multipotent Stem Cells, Wnt Proteins, beta Catenin, Rats, Embryonic Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
