The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Concise Review: Isoforms of OCT4 Contribute to the Confusing Diversity in Stem Cell Biology
Open accessAbstract
The human OCT4 gene can generate at least three transcripts (OCT4A, OCT4B, and OCT4B1) and four protein isoforms (OCT4A, OCT4B-190, OCT4B-265, and OCT4B-164) by alternative splicing and alternative translation initiation. OCT4A is a transcription factor responsible for the pluripotency properties of embryonic stem (ES) cells. While OCT4B cannot sustain ES cell self-renewal, it may respond to cell stresses. Yet, the function of OCT4B1 is still unclear. Lack of distinction of OCT4 isoforms could lead to confusions and controversies on OCT4 in various tissues and cells. One important issue we emphasize in this review article is that alternatively spliced transcripts and alternative translation products of OCT4 exhibit diverse expression patterns and functions. Furthermore, simple approaches and methods to detect and distinguish OCT4 isoforms are discussed. This article underscores the importance of identifying and discriminating the expression and functions of OCT4 isoforms in stem cell research.
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Cites
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310
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Herr, W., & Cleary, M. A. (1995) · Genes & Development · doi:10.1101/gad.9.14.1679 · Cited by 388
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Cited by
Functional consequences of developmentally regulated alternative splicing
Kalsotra, A., & Cooper, T. A. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3052 · Cited by 729
HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells
Mathieu, J., Zhang, Z., Zhou, W., Wang, A. J., Heddleston, J. M., Pinna, C. M. A., Hubaud, A., Stadler, B., Choi, M., Bar, M., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3320 · Cited by 508
Role of Oct4 in maintaining and regaining stem cell pluripotency
Shi, G., & Jin, Y. (2010) · Stem Cell Research & Therapy · doi:10.1186/scrt39 · Cited by 294
You, J. S., Kelly, T. K., De Carvalho, D. D., Taberlay, P. C., Liang, G., & Jones, P. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111309108 · Cited by 115
Metadata
- Authors
- Wang, X., & Dai, J.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-03-23
- Volume
- 28
- Issue
- 5
- Pages
- 885-893
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W1877598057
- Cited by
- 223
- References
- 4
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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