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Cited by 729RNA Research and SplicingRNA regulation and diseaseCancer-related molecular mechanisms research

Functional consequences of developmentally regulated alternative splicing

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Kalsotra, Auinash, Cooper, Thomas A.·2011·Nature Reviews Genetics
DOI 10.1038/nrg3052PMC PMC3321218
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Abstract

Genome-wide analyses of metazoan transcriptomes have revealed an unexpected level of mRNA diversity that is generated by alternative splicing. Recently, regulatory networks have been identified through which splicing promotes dynamic remodelling of the transcriptome to promote physiological changes, which involve robust and coordinated alternative splicing transitions. The regulation of splicing in yeast, worms, flies and vertebrates affects a variety of biological processes. The functional classes of genes that are regulated by alternative splicing include both those with widespread homeostatic activities and those with cell-type-specific functions. Alternative splicing can drive determinative physiological change or can have a permissive role by providing mRNA variability that is used by other regulatory mechanisms.

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  • RNA processing and miRNA-mediated gene silencing are fundamental mechanisms that fine-tune gene expression to regulate tissue development and physiology.

    “RNA processing and miRNA-mediated gene silencing are fundamental mechanisms that fine-tune gene expression to regulate tissue development and physiology (Kalsotra and Cooper 2011; Baralle and Giudice 2017; Bartel 2018; Marasco and Kornblihtt 2023)”

    From ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation (2025) · cites this paper as Kalsotra and Cooper 2011

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Authors
Kalsotra, A., & Cooper, T. A.
Affiliations
Baylor College of Medicine (US)
Corresponding author
Cooper, Thomas A.
ORCID
Venue
Nature Reviews Genetics
Publisher
Springer Science and Business Media LLC
Published
2011-09-16
Volume
12
Issue
10
Pages
715-729
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
DOI
10.1038/nrg3052
PMC
PMC3321218
OpenAlex
W2024036230
Cited by
729
References
17
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FWCI
4.93
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL045565, R01HL045565)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR045653, AR060733, R01AR045653, R01AR060733)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
alternative splicing, splicing regulatory network, cell type-specific gene expression, physiological adaptation, yeast, Caenorhabditis elegans, Drosophila, vertebrates
MeSH terms
Animals, Cell Differentiation, Cell Division, Humans, Models, Biological, Alternative Splicing, Gene Expression Regulation, Developmental, Organogenesis, Genes, Developmental

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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